Development Level

Tbio 234 | 11,445
Tchem 66 | 1,598
Tclin 38 | 613
Tdark 18 | 6,588

Collection

RFA-RM-18-021 7 | 328
Ion Channel: IDG Consortium (T... 4 | 99
GPCR: IDG Consortium (Targets) 2 | 126
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 25 | 979
abnormal retina morphology 9 | 71
increased startle reflex 9 | 112
abnormal bone structure 8 | 187
decreased total body fat amoun... 7 | 207
embryonic lethality prior to t... 7 | 278
increased circulating HDL chol... 7 | 80
decreased grip strength 6 | 116
embryonic lethality prior to o... 6 | 239
abnormal behavior 5 | 298
decreased body weight 5 | 161
increased blood urea nitrogen ... 5 | 48
increased heart weight 5 | 62
increased lean body mass 5 | 172
preweaning lethality, incomple... 5 | 499
abnormal kidney morphology 4 | 65
decreased bone mineral content 4 | 151
decreased circulating glucose ... 4 | 126
decreased startle reflex 4 | 75
hypoactivity 4 | 132
impaired glucose tolerance 4 | 75
improved glucose tolerance 4 | 79
increased circulating alkaline... 4 | 122
increased circulating choleste... 4 | 66
increased or absent threshold ... 4 | 101
increased total body fat amoun... 4 | 134
abnormal pelvic girdle bone mo... 3 | 12
abnormal vibrissa morphology 3 | 25
decreased circulating choleste... 3 | 93
decreased circulating insulin ... 3 | 76
decreased circulating triglyce... 3 | 79
decreased lean body mass 3 | 135
decreased mean corpuscular vol... 3 | 79
decreased vertical activity 3 | 208
enlarged heart 3 | 210
increased anti-nuclear antigen... 3 | 19
increased circulating creatini... 3 | 38
increased circulating iron lev... 3 | 30
increased circulating sodium l... 3 | 71
increased circulating total pr... 3 | 28
increased mean corpuscular vol... 3 | 92
abnormal cornea morphology 2 | 31
abnormal embryo size 2 | 220
abnormal embryo turning 2 | 31
abnormal heart morphology 2 | 162
abnormal lens morphology 2 | 81
abnormal optic disc morphology 2 | 10
abnormal pericardium morpholog... 2 | 26
abnormal retinal blood vessel ... 2 | 26
abnormal retinal vasculature m... 2 | 27
abnormal seminal vesicle morph... 2 | 114
abnormal sleep behavior 2 | 70
cataract 2 | 92
corneal opacity 2 | 32
decreased body length 2 | 101
decreased bone mineral density 2 | 126
decreased circulating HDL chol... 2 | 68
decreased eosinophil cell numb... 2 | 24
decreased fasted circulating g... 2 | 65
decreased hemoglobin content 2 | 68
decreased prepulse inhibition 2 | 82
embryonic growth retardation 2 | 106
enlarged kidney 2 | 14
impaired righting response 2 | 26
increased body weight 2 | 25
increased bone mineral content 2 | 108
increased bone mineral density 2 | 72
increased circulating calcium ... 2 | 34
increased grip strength 2 | 41
increased leukocyte cell numbe... 2 | 47
increased lymphocyte cell numb... 2 | 32
increased mean platelet volume 2 | 45
increased monocyte cell number 2 | 63
limb grasping 2 | 41
mammalian phenotype 2 | 17
persistence of hyaloid vascula... 2 | 33
polycystic kidney 2 | 15
prolonged QT interval 2 | 38
prolonged ST segment 2 | 36
abnormal cranium morphology 1 | 36
abnormal ear morphology 1 | 9
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal spleen morphology 1 | 55
abnormal tail movements 1 | 12
abnormal vertebrae morphology 1 | 18
abnormal whole-body plethysmog... 1 | 4
absent vibrissae 1 | 12
decreased circulating amylase ... 1 | 28
decreased circulating chloride... 1 | 30
decreased circulating potassiu... 1 | 20
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
enlarged spleen 1 | 41
impaired pupillary reflex 1 | 26
increased circulating amylase ... 1 | 25
iris synechia 1 | 3
prenatal lethality 1 | 28
thin ventricular wall 1 | 24

Disease

Carcinoma 269 | 11,493
psoriasis 163 | 6,694
ovarian cancer 159 | 8,520
osteosarcoma 150 | 7,950
lung cancer 131 | 4,740
Cancer 120 | 2,499
medulloblastoma, large-cell 110 | 6,241
intraductal papillary-mucinous adenoma (IPMA) 105 | 2,955
glioblastoma 103 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 103 | 3,291
ependymoma 98 | 4,679
Breast cancer 95 | 3,578
non-small cell lung cancer 93 | 2,890
intraductal papillary-mucinous carcinoma (IPMC) 92 | 2,989
Kidney cancer 87 | 2,613
pancreatic cancer 87 | 2,398
atypical teratoid / rhabdoid tumor 86 | 5,112
lung adenocarcinoma 86 | 2,716
malignant mesothelioma 86 | 3,232
lung carcinoma 82 | 2,843
interstitial cystitis 76 | 2,312
Autosomal recessive predisposition 73 | 1,442
adult high grade glioma 70 | 3,801
invasive ductal carcinoma 69 | 2,951
cystic fibrosis 66 | 1,696
pituitary cancer 65 | 1,972
group 3 medulloblastoma 64 | 4,104
ulcerative colitis 64 | 1,819
Kidney disease 63 | 430
Astrocytoma, Pilocytic 61 | 3,081
diabetes mellitus 58 | 1,728
oligodendroglioma 56 | 2,850
ductal carcinoma in situ 55 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 51 | 1,962
Hypertension 50 | 396
colon cancer 50 | 1,478
astrocytic glioma 49 | 2,597
subependymal giant cell astrocytoma 49 | 2,287
tuberculosis 46 | 2,010
Diarrhea 44 | 253
active Crohn's disease 44 | 922
Schizophrenia 43 | 1,160
primitive neuroectodermal tumor 43 | 3,035
esophageal adenocarcinoma 42 | 737
active ulcerative colitis 39 | 764
nasopharyngeal carcinoma 39 | 1,058
Rheumatoid arthritis 37 | 1,191
breast carcinoma 37 | 1,638
Epilepsy 36 | 792
cutaneous lupus erythematosus 35 | 1,057
Obesity 33 | 678
adrenocortical carcinoma 33 | 1,428
nephrosclerosis 33 | 333
spina bifida 33 | 1,074
Pick disease 32 | 1,894
Liver Cirrhosis, Experimental 31 | 769
Liver cancer 31 | 604
Melanoma 31 | 711
Metabolic acidosis 31 | 90
Breast Neoplasms 30 | 445
Intellectual disability 30 | 1,016
Mammary Neoplasms 30 | 425
Liver disease 29 | 237
Prostatic Neoplasms 29 | 495
primary pancreatic ductal adenocarcinoma 29 | 1,109
Cholestasis 28 | 155
Coronary artery disease 28 | 268
group 4 medulloblastoma 28 | 1,855
Alzheimer's disease 27 | 658
Anemia 27 | 365
Failure to gain weight 27 | 365
Heart disease 27 | 306
Pediatric failure to thrive 27 | 365
Hypertensive disease 26 | 292
Osteoporosis 26 | 363
Skin cancer 26 | 469
gastric carcinoma 26 | 807
Dull intelligence 25 | 645
Low intelligence 25 | 645
Mental Retardation 25 | 645
Mental deficiency 25 | 645
Poor school performance 25 | 645
Atherosclerosis 24 | 291
Down syndrome 24 | 499
Endometriosis 24 | 540
Cerebrovascular disease 23 | 238
pediatric high grade glioma 23 | 1,064
Inflammatory bowel disease 22 | 151
acute quadriplegic myopathy 22 | 1,158
Seizures 21 | 596
chronic rhinosinusitis 21 | 512
juvenile dermatomyositis 21 | 1,187
Adenoma 20 | 167
Asthma 20 | 385
Short stature 20 | 531
dermatomyositis 20 | 966
non primary Sjogren syndrome sicca 20 | 891
Hyperuricemia 19 | 49
Gout 18 | 106
aldosterone-producing adenoma 18 | 665

Tissue

Endocrine System 333 | 18,159
Digestive Tract 332 | 17,369
Urinary Tract 327 | 16,678
Skin and soft tissues 324 | 17,230
Female tissues 322 | 17,400
Male tissues 322 | 17,142
Liver and Pancreas 318 | 16,750
Blood and immune system 308 | 16,909
Nervous System 303 | 16,725
Respiratory system 294 | 16,393
Cardiovascular System 253 | 15,192

Target Family

Non-IDG 176 | 12,091
Transporter 84 | 473
Enzyme 45 | 4,145
Ion Channel 25 | 344
Kinase 11 | 634
GPCR 9 | 408
Transcription Factor 6 | 1,400

Compartment GO Term

Apical part of cell 356 | 356
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,109 | 14,109
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,975 | 8,975
Intracellular organelle part 8,783 | 8,783
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,628 | 1,628
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 663 | 663
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Homeobox protein MSX-1 MSX1 Tbio Transcription Factor -2.59245 390.1 298
Sodium/bile acid cotransporter SLC10A1 Tchem Transporter -2.69150 476.1 163
Adherens junction-associated protein 1 AJAP1 Tbio Non-IDG -1.20907 21.2 25
TRAF2 and NCK-interacting protein kinase TNIK Tchem Kinase -1.33394 28.5 441
Potassium voltage-gated channel subfamily C member 2 KCNC2 Tclin Ion Channel -1.45272 28.7 178
Aquaporin-8 AQP8 Tbio Non-IDG -2.06724 116.3 124
L-amino-acid oxidase IL4I1 Tbio Enzyme -2.79074 622.3 53
Sodium bicarbonate cotransporter 3 SLC4A7 Tbio Transporter -1.82039 64.7 133
Protein Shroom2 SHROOM2 Tbio Non-IDG -1.07032 11.9 112
Mucin-16 MUC16 Tbio Non-IDG -2.09951 138.4 0