Development Level

Tbio 115 | 11,651
Tchem 31 | 1,388
Tclin 24 | 612
Tdark 3 | 6,593

Collection

Ion Channel: IDG Consortium (T... 3 | 99

IMPC Phenotype

preweaning lethality, complete... 15 | 979
embryonic lethality prior to o... 5 | 239
embryonic lethality prior to t... 5 | 278
increased circulating HDL chol... 5 | 80
abnormal retina morphology 4 | 71
increased total body fat amoun... 4 | 134
abnormal behavior 3 | 298
decreased body weight 3 | 161
decreased grip strength 3 | 116
increased blood urea nitrogen ... 3 | 48
increased circulating alkaline... 3 | 122
increased circulating creatini... 3 | 38
increased circulating total pr... 3 | 28
increased startle reflex 3 | 112
abnormal kidney morphology 2 | 65
abnormal lens morphology 2 | 81
abnormal optic disc morphology 2 | 10
cataract 2 | 92
decreased bone mineral density 2 | 126
decreased lean body mass 2 | 135
decreased mean corpuscular vol... 2 | 79
enlarged kidney 2 | 14
hypoactivity 2 | 132
impaired glucose tolerance 2 | 75
improved glucose tolerance 2 | 79
increased body weight 2 | 25
increased bone mineral density 2 | 72
increased circulating choleste... 2 | 66
mammalian phenotype 2 | 17
persistence of hyaloid vascula... 2 | 33
polycystic kidney 2 | 15
preweaning lethality, incomple... 2 | 499
prolonged QT interval 2 | 38
prolonged ST segment 2 | 36
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal facial morphology 1 | 17
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 162
abnormal lung morphology 1 | 26
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal sleep behavior 1 | 70
abnormal snout morphology 1 | 23
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal tail movements 1 | 12
abnormal urinary bladder morph... 1 | 11
abnormal vertebrae morphology 1 | 18
cardiovascular system phenotyp... 1 | 36
cleft palate 1 | 8
corneal opacity 1 | 32
cyanosis 1 | 7
cystolithiasis 1 | 3
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating serum al... 1 | 82
decreased fasted circulating g... 1 | 65
decreased heart left ventricle... 1 | 28
decreased hemoglobin content 1 | 68
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
decreased spleen weight 1 | 10
decreased startle reflex 1 | 75
decreased threshold for audito... 1 | 26
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
enlarged spleen 1 | 41
enlarged urinary bladder 1 | 8
female infertility 1 | 60
hydrometra 1 | 53
impaired pupillary reflex 1 | 26
impaired righting response 1 | 26
increased anti-nuclear antigen... 1 | 19
increased circulating amylase ... 1 | 25
increased circulating bilirubi... 1 | 16
increased circulating calcium ... 1 | 34
increased circulating serum al... 1 | 22
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
increased spleen weight 1 | 10
iris synechia 1 | 3
limb grasping 1 | 41
narrow eye opening 1 | 12
short tibia 1 | 97
small kidney 1 | 16
small superior vagus ganglion 1 | 74
thin ventricular wall 1 | 24

Disease

Carcinoma 132 | 11,493
psoriasis 84 | 6,694
Cancer 78 | 2,499
ovarian cancer 72 | 8,520
osteosarcoma 68 | 7,950
lung cancer 64 | 4,740
intraductal papillary-mucinous adenoma (IPMA) 54 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 52 | 3,291
intraductal papillary-mucinous carcinoma (IPMC) 49 | 2,989
medulloblastoma, large-cell 48 | 6,241
Breast cancer 47 | 3,578
malignant mesothelioma 45 | 3,232
Kidney cancer 44 | 2,613
glioblastoma 43 | 5,792
non-small cell lung cancer 43 | 2,890
atypical teratoid / rhabdoid tumor 41 | 5,112
Autosomal recessive predisposition 40 | 1,442
cystic fibrosis 40 | 1,696
ependymoma 40 | 4,679
interstitial cystitis 40 | 2,312
lung adenocarcinoma 39 | 2,716
Kidney disease 38 | 430
pancreatic cancer 38 | 2,398
lung carcinoma 36 | 2,843
Diarrhea 35 | 253
diabetes mellitus 33 | 1,728
Hypertension 31 | 396
group 3 medulloblastoma 31 | 4,104
ulcerative colitis 30 | 1,819
adult high grade glioma 29 | 3,801
pancreatic ductal adenocarcinoma liver metastasis 28 | 1,962
active ulcerative colitis 27 | 764
pituitary cancer 27 | 1,972
Epilepsy 26 | 792
invasive ductal carcinoma 26 | 2,951
tuberculosis 26 | 2,010
active Crohn's disease 25 | 922
colon cancer 25 | 1,478
oligodendroglioma 25 | 2,850
Astrocytoma, Pilocytic 24 | 3,081
Liver disease 23 | 237
Metabolic acidosis 23 | 90
Schizophrenia 23 | 1,160
ductal carcinoma in situ 23 | 1,745
Breast Neoplasms 22 | 445
Cholestasis 22 | 155
Mammary Neoplasms 22 | 425
Rheumatoid arthritis 22 | 1,191
astrocytic glioma 22 | 2,597
primitive neuroectodermal tumor 22 | 3,035
subependymal giant cell astrocytoma 22 | 2,287
Prostatic Neoplasms 21 | 495
esophageal adenocarcinoma 21 | 737
Heart disease 20 | 306
cutaneous lupus erythematosus 20 | 1,057
Coronary artery disease 19 | 268
Liver Cirrhosis, Experimental 19 | 769
Liver cancer 19 | 604
nasopharyngeal carcinoma 19 | 1,058
Anemia 18 | 365
Cerebrovascular disease 18 | 238
Failure to gain weight 18 | 365
Pediatric failure to thrive 18 | 365
breast carcinoma 18 | 1,638
Alzheimer's disease 17 | 658
Inflammatory bowel disease 17 | 151
Obesity 17 | 678
Melanoma 16 | 711
adrenocortical carcinoma 16 | 1,428
nephrosclerosis 16 | 333
Colorectal Neoplasms 15 | 243
Osteoporosis 15 | 363
Pick disease 15 | 1,894
Down syndrome 14 | 499
Endometriosis 14 | 540
Hypertensive disease 14 | 292
Hypokalemia 14 | 52
Intellectual disability 14 | 1,016
Short stature 14 | 531
primary pancreatic ductal adenocarcinoma 14 | 1,109
spina bifida 14 | 1,074
Atherosclerosis 13 | 291
Cognitive delay 13 | 608
Global developmental delay 13 | 608
Mental and motor retardation 13 | 608
Seizures 13 | 596
Barrett's esophagus 12 | 182
Constipation 12 | 181
Dull intelligence 12 | 645
Low intelligence 12 | 645
Mental Retardation 12 | 645
Mental deficiency 12 | 645
Poor school performance 12 | 645
Skin cancer 12 | 469
pediatric high grade glioma 12 | 1,064
Adenoma 11 | 167
Asthma 11 | 385
Stomach Neoplasms 11 | 300
chronic rhinosinusitis 11 | 512
gastric carcinoma 11 | 807

Tissue

Digestive Tract 165 | 17,369
Urinary Tract 164 | 16,678
Endocrine System 160 | 18,159
Skin and soft tissues 159 | 17,230
Female tissues 157 | 17,400
Male tissues 157 | 17,142
Liver and Pancreas 154 | 16,750
Blood and immune system 146 | 16,909
Nervous System 144 | 16,725
Respiratory system 139 | 16,393
Cardiovascular System 115 | 15,192

Target Family

Non-IDG 78 | 12,091
Transporter 55 | 473
Ion Channel 15 | 344
Enzyme 14 | 4,145
Transcription Factor 5 | 1,400
Kinase 4 | 634
GPCR 2 | 408

Compartment GO Term

Apical complex 173 | 173
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
STE20/SPS1-related proline-alanine-rich protein kinase STK39 Tbio Kinase -2.11714 148.9 575
Protein crumbs homolog 3 CRB3 Tbio Non-IDG -1.22596 16.1 79
Potassium voltage-gated channel subfamily E member 1 KCNE1 Tbio Ion Channel -2.67495 441.7 193
Solute carrier organic anion transporter family member 1B1 SLCO1B1 Tchem Transporter -2.77788 574.0 124
Ezrin EZR Tbio Non-IDG -2.99865 981.3 1088
Vasopressin-neurophysin 2-copeptin AVP Tbio Non-IDG -3.92570 8381.2 203
Pro-epidermal growth factor EGF Tbio Non-IDG -3.75933 4903.2 978
Unconventional myosin-Vb MYO5B Tbio Non-IDG -1.96052 93.4 42