Development Level

Tbio 553 | 10,625
Tchem 107 | 1,890
Tdark 22 | 7,003
Tclin 20 | 602

Collection

Eligible Kinase Proteins 4 | 134
Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 32 | 633
preweaning lethality, incomple... 17 | 260
decreased total body fat amoun... 14 | 186
decreased body weight 13 | 174
decreased lean body mass 12 | 195
increased lean body mass 11 | 107
abnormal behavior 10 | 226
abnormal retina morphology 10 | 100
embryonic lethality prior to t... 10 | 187
abnormal embryo size 9 | 112
decreased circulating choleste... 8 | 85
increased or absent threshold ... 8 | 128
abnormal sleep behavior 7 | 63
decreased bone mineral content 7 | 157
decreased circulating HDL chol... 7 | 77
decreased circulating glucose ... 7 | 121
decreased bone mineral density 6 | 126
decreased circulating alanine ... 6 | 53
decreased mean corpuscular vol... 6 | 50
improved glucose tolerance 6 | 56
abnormal bone structure 5 | 131
decreased circulating insulin ... 5 | 75
embryonic lethality prior to o... 5 | 148
increased body weight 5 | 42
increased bone mineral content 5 | 92
increased circulating HDL chol... 5 | 63
abnormal pericardium morpholog... 4 | 11
abnormal retinal pigmentation 4 | 61
decreased circulating free fat... 4 | 39
decreased circulating serum al... 4 | 79
decreased circulating triglyce... 4 | 83
decreased eosinophil cell numb... 4 | 41
decreased fasted circulating g... 4 | 49
decreased mean corpuscular hem... 4 | 34
enlarged heart 4 | 111
hypoactivity 4 | 89
increased blood urea nitrogen ... 4 | 44
increased bone mineral density 4 | 52
increased circulating choleste... 4 | 53
increased circulating sodium l... 4 | 71
increased hematocrit 4 | 36
increased leukocyte cell numbe... 4 | 37
increased mean corpuscular vol... 4 | 91
abnormal neural tube closure 3 | 37
decreased circulating LDL chol... 3 | 37
decreased circulating calcium ... 3 | 33
decreased circulating fructosa... 3 | 31
decreased circulating iron lev... 3 | 25
decreased circulating total pr... 3 | 41
decreased grip strength 3 | 123
decreased startle reflex 3 | 48
enlarged lymph nodes 3 | 27
hyperactivity 3 | 108
impaired glucose tolerance 3 | 52
increased body length 3 | 20
increased circulating alkaline... 3 | 119
increased circulating chloride... 3 | 43
increased circulating triglyce... 3 | 24
increased fasted circulating g... 3 | 68
increased grip strength 3 | 83
increased mean corpuscular hem... 3 | 93
male infertility 3 | 62
short tibia 3 | 82
shortened RR interval 3 | 19
abnormal behavioral response t... 2 | 52
abnormal bone mineralization 2 | 55
abnormal cornea morphology 2 | 24
abnormal craniofacial morpholo... 2 | 12
abnormal eye morphology 2 | 38
abnormal gait 2 | 51
abnormal head morphology 2 | 10
abnormal hindbrain development 2 | 24
abnormal midbrain development 2 | 22
abnormal skin morphology 2 | 23
abnormal vertebrae morphology 2 | 14
cardiovascular system phenotyp... 2 | 35
decreased NK T cell number 2 | 28
decreased basophil cell number 2 | 11
decreased body length 2 | 108
decreased circulating alkaline... 2 | 41
decreased circulating aspartat... 2 | 27
decreased circulating chloride... 2 | 32
decreased hemoglobin content 2 | 53
decreased lactate dehydrogenas... 2 | 14
decreased rib number 2 | 59
decreased vertical activity 2 | 22
enlarged spleen 2 | 26
hydrops fetalis 2 | 22
increased circulating calcium ... 2 | 32
increased circulating phosphat... 2 | 24
increased exploration in new e... 2 | 56
increased heart rate 2 | 17
increased heart weight 2 | 37
increased red blood cell distr... 2 | 21
increased vertical activity 2 | 18
pallor 2 | 13
prenatal lethality prior to he... 2 | 64
shortened ST segment 2 | 9
thrombocytosis 2 | 23
tremors 2 | 34

Disease

ovarian cancer 455 | 8,484
osteosarcoma 374 | 7,933
glioblastoma 329 | 5,572
psoriasis 306 | 6,685
medulloblastoma, large-cell 303 | 6,234
lung cancer 264 | 4,466
atypical teratoid / rhabdoid tumor 247 | 4,369
Cancer 225 | 2,346
intraductal papillary-mucinous neoplasm (IPMN) 217 | 3,289
pancreatic cancer 198 | 2,300
intraductal papillary-mucinous carcinoma (IPMC) 195 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 193 | 2,956
non-small cell lung cancer 185 | 2,798
invasive ductal carcinoma 184 | 2,950
Breast cancer 182 | 3,094
lung adenocarcinoma 182 | 2,713
pediatric high grade glioma 182 | 2,712
pilocytic astrocytoma 174 | 3,086
malignant mesothelioma 167 | 3,162
oligodendroglioma 156 | 2,849
ependymoma 149 | 2,514
Carcinoma 145 | 2,147
primitive neuroectodermal tumor 145 | 3,031
lung carcinoma 144 | 2,844
primary pancreatic ductal adenocarcinoma 142 | 1,271
group 4 medulloblastoma 127 | 1,875
interstitial cystitis 127 | 2,299
subependymal giant cell astrocytoma 126 | 2,287
astrocytoma 125 | 1,493
Multiple myeloma 118 | 1,327
ulcerative colitis 114 | 2,087
acute quadriplegic myopathy 108 | 1,157
diabetes mellitus 107 | 1,663
astrocytic glioma 106 | 2,241
breast carcinoma 105 | 1,614
juvenile dermatomyositis 105 | 1,189
cystic fibrosis 102 | 1,665
dermatomyositis 102 | 933
ductal carcinoma in situ 101 | 1,745
tuberculosis 97 | 1,557
Pick disease 95 | 1,893
pancreatic ductal adenocarcinoma liver metastasis 93 | 1,795
Waldenstrons macroglobulinemia 90 | 765
colon cancer 90 | 1,475
spina bifida 90 | 1,064
pituitary cancer 89 | 1,972
sonic hedgehog group medulloblastoma 87 | 1,482
Rheumatoid Arthritis 79 | 1,160
adult high grade glioma 78 | 2,148
posterior fossa group A ependymoma 77 | 1,511
adrenocortical carcinoma 74 | 1,427
medulloblastoma 73 | 1,524
esophageal adenocarcinoma 69 | 737
gastric carcinoma 68 | 832
group 3 medulloblastoma 66 | 2,254
Duchenne muscular dystrophy 65 | 602
autosomal dominant Emery-Dreifuss muscular dystrophy 60 | 499
posterior fossa group B ependymoma 59 | 1,530
Down syndrome 55 | 548
Alzheimer's disease 52 | 644
cutaneous lupus erythematosus 50 | 1,056
nasopharyngeal carcinoma 48 | 1,056
Prostatic Neoplasms 46 | 471
Mammary Neoplasms 45 | 410
atypical teratoid/rhabdoid tumor 44 | 1,095
active Crohn's disease 40 | 918
progressive supranuclear palsy 40 | 674
aldosterone-producing adenoma 39 | 664
mucosa-associated lymphoid tissue lymphoma 39 | 480
tuberculosis and treatment for 6 months 39 | 686
fibroadenoma 38 | 557
primary Sjogren syndrome 38 | 789
IGA Glomerulonephritis 37 | 454
acute myeloid leukemia 36 | 780
pancreatic carcinoma 36 | 567
non primary Sjogren syndrome sicca 35 | 840
Amyotrophic Lateral Sclerosis 33 | 431
Atopic dermatitis 33 | 944
Kidney disease 33 | 396
Vascular disease 33 | 281
hereditary spastic paraplegia 33 | 313
Stomach Neoplasms 31 | 282
Osteoporosis 30 | 257
non-small cell lung carcinoma 30 | 413
Liver carcinoma 29 | 217
Multiple Sclerosis 29 | 498
Neoplasm Invasiveness 29 | 127
Neoplasm Metastasis 29 | 138
interstitial lung disease 29 | 291
Intellectual disability 28 | 573
Becker muscular dystrophy 27 | 187
gastric cancer 27 | 430
Neurodegenerative disease 26 | 383
active ulcerative colitis 26 | 477
Cardiomyopathy 24 | 110
Parkinson's disease 24 | 364
Squamous cell carcinoma 24 | 94
Endometriosis 23 | 535
Obesity 23 | 616
Polycystic Ovary Syndrome 23 | 332

Tissue

Blood and immune system 693 | 17,995
Cardiovascular System 693 | 17,958
Female tissues 693 | 18,647
Liver and Pancreas 693 | 18,136
Digestive Tract 692 | 18,473
Endocrine System 692 | 18,512
Male tissues 692 | 17,969
Nervous System 692 | 18,561
Urinary Tract 692 | 18,444
Respiratory system 691 | 17,484
Skin and soft tissues 688 | 18,115

Target Family

Non-IDG 522 | 11,971
Enzyme 116 | 4,146
Kinase 47 | 634
Transporter 5 | 473
GPCR 4 | 406
Transcription Factor 4 | 1,400
Epigenetic 2 | 242
Ion Channel 2 | 341

Compartment GO Term

Anchoring junction 702 | 702
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Endoplasmin HSP90B1 Tchem Non-IDG -2.72785 604.5 748
Charged multivesicular body protein 2b CHMP2B Tbio Non-IDG -1.65708 53.0 166
Desmoplakin DSP Tbio Non-IDG -2.90088 786.5 167
F-actin-capping protein subunit alpha-1 CAPZA1 Tbio Non-IDG -1.28182 20.1 139
Keratin, type II cytoskeletal 74 KRT74 Tbio Non-IDG -2.22050 159.7 35
Host cell factor 1 HCFC1 Tbio Non-IDG -2.50024 341.6 160
Fatty acid synthase FASN Tchem Enzyme -2.49948 348.5 388
Pyruvate kinase PKM PKM Tchem Kinase -3.09101 1313.5 672
Actin-related protein 2 ACTR2 Tchem Non-IDG -1.84526 72.5 184