Development Level

Tbio 232 | 11,178
Tchem 35 | 1,885
Tdark 19 | 6,569
Tclin 13 | 612

Collection

Kinase: IDG Consortium (Comple... 2 | 37
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 29 | 979
embryonic lethality prior to t... 11 | 278
preweaning lethality, incomple... 9 | 499
abnormal embryo size 8 | 220
embryonic lethality prior to o... 8 | 239
abnormal retina morphology 7 | 71
embryonic growth retardation 7 | 106
abnormal behavior 6 | 298
decreased body weight 5 | 161
decreased bone mineral content 4 | 151
decreased circulating glucose ... 4 | 126
decreased fasted circulating g... 4 | 65
decreased total body fat amoun... 4 | 207
edema 4 | 59
hypoactivity 4 | 132
increased lean body mass 4 | 172
increased startle reflex 4 | 112
male infertility 4 | 123
abnormal bone structure 3 | 187
abnormal pericardium morpholog... 3 | 26
decreased body length 3 | 101
decreased grip strength 3 | 116
decreased leukocyte cell numbe... 3 | 73
decreased startle reflex 3 | 75
decreased vertical activity 3 | 208
hyperactivity 3 | 148
increased blood urea nitrogen ... 3 | 48
increased body weight 3 | 25
increased bone mineral density 3 | 72
increased circulating choleste... 3 | 66
increased mean corpuscular vol... 3 | 92
increased total body fat amoun... 3 | 134
abnormal bone mineralization 2 | 38
abnormal cornea morphology 2 | 31
abnormal craniofacial morpholo... 2 | 33
abnormal eye morphology 2 | 68
abnormal neural tube closure 2 | 46
abnormal skin morphology 2 | 50
abnormal sleep behavior 2 | 70
abnormal testis morphology 2 | 43
decreased bone mineral density 2 | 126
decreased circulating alanine ... 2 | 47
decreased circulating choleste... 2 | 93
decreased circulating insulin ... 2 | 76
decreased circulating iron lev... 2 | 32
decreased circulating serum al... 2 | 82
decreased eosinophil cell numb... 2 | 24
decreased lean body mass 2 | 135
decreased lymphocyte cell numb... 2 | 83
improved glucose tolerance 2 | 79
increased circulating HDL chol... 2 | 80
increased circulating alkaline... 2 | 122
increased circulating iron lev... 2 | 30
increased circulating triglyce... 2 | 42
increased grip strength 2 | 41
increased heart weight 2 | 62
increased neutrophil cell numb... 2 | 46
increased or absent threshold ... 2 | 101
persistence of hyaloid vascula... 2 | 33
prenatal lethality prior to he... 2 | 87
short tibia 2 | 97
small testis 2 | 58
thrombocytopenia 2 | 56
abnormal behavioral response t... 1 | 66
abnormal cranium morphology 1 | 36
abnormal gait 1 | 69
abnormal head morphology 1 | 10
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal optic disc morphology 1 | 10
abnormal retinal vasculature m... 1 | 27
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal tail movements 1 | 12
abnormal vertebrae morphology 1 | 18
abnormal vocalization 1 | 21
abnormal whole-body plethysmog... 1 | 4
brachydactyly 1 | 19
decreased T cell number 1 | 15
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating phosphat... 1 | 27
decreased erythrocyte cell num... 1 | 62
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
dilated heart left ventricle 1 | 11
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
enlarged uterus 1 | 11
hydrometra 1 | 53
impaired righting response 1 | 26
increased circulating potassiu... 1 | 29
increased fasted circulating g... 1 | 76
increased monocyte cell number 1 | 63
prenatal lethality 1 | 28
small kidney 1 | 16
small superior vagus ganglion 1 | 74
small thymus 1 | 16
syndactyly 1 | 23
tremors 1 | 39

Disease

Carcinoma 224 | 11,192
ovarian cancer 189 | 8,297
osteosarcoma 173 | 7,766
glioblastoma 148 | 5,635
medulloblastoma, large-cell 140 | 6,086
psoriasis 136 | 6,514
atypical teratoid / rhabdoid tumor 120 | 4,971
ependymoma 114 | 4,559
lung cancer 112 | 4,607
Cancer 111 | 2,388
non-small cell lung cancer 103 | 2,799
Breast cancer 98 | 3,469
intraductal papillary-mucinous neoplasm (IPMN) 96 | 3,204
intraductal papillary-mucinous carcinoma (IPMC) 95 | 2,902
intraductal papillary-mucinous adenoma (IPMA) 91 | 2,872
group 3 medulloblastoma 88 | 4,002
adult high grade glioma 87 | 3,701
malignant mesothelioma 86 | 3,135
Astrocytoma, Pilocytic 85 | 3,006
invasive ductal carcinoma 84 | 2,867
pancreatic cancer 84 | 2,322
Kidney cancer 78 | 2,548
interstitial cystitis 77 | 2,237
lung adenocarcinoma 76 | 2,627
lung carcinoma 74 | 2,755
primitive neuroectodermal tumor 73 | 2,957
oligodendroglioma 68 | 2,768
subependymal giant cell astrocytoma 64 | 2,230
astrocytic glioma 57 | 2,530
cystic fibrosis 52 | 1,629
ductal carcinoma in situ 52 | 1,686
breast carcinoma 50 | 1,589
pituitary cancer 50 | 1,915
spina bifida 50 | 1,053
group 4 medulloblastoma 48 | 1,806
ulcerative colitis 47 | 1,765
primary pancreatic ductal adenocarcinoma 46 | 1,071
tuberculosis 46 | 1,963
pancreatic ductal adenocarcinoma liver metastasis 45 | 1,911
Pick disease 43 | 1,856
diabetes mellitus 41 | 1,683
adrenocortical carcinoma 39 | 1,385
astrocytoma 39 | 1,113
colon cancer 39 | 1,428
dermatomyositis 37 | 941
acute quadriplegic myopathy 33 | 1,133
juvenile dermatomyositis 33 | 1,147
pediatric high grade glioma 33 | 1,035
Liver Cirrhosis, Experimental 32 | 733
esophageal adenocarcinoma 31 | 696
Melanoma 29 | 689
Rheumatoid arthritis 29 | 1,156
Autosomal recessive predisposition 28 | 1,407
Schizophrenia 27 | 1,136
Skin cancer 25 | 451
nasopharyngeal carcinoma 25 | 1,024
Intellectual disability 24 | 998
Prostatic Neoplasms 24 | 472
Breast Neoplasms 23 | 423
Down syndrome 23 | 480
autosomal dominant Emery-Dreifuss muscular dystrophy 23 | 492
cutaneous lupus erythematosus 23 | 1,016
gastric carcinoma 23 | 781
Mammary Neoplasms 22 | 403
Multiple myeloma 21 | 1,296
Waldenstrons macroglobulinemia 21 | 742
aldosterone-producing adenoma 20 | 646
Duchenne muscular dystrophy 19 | 587
Kidney disease 19 | 411
Liver cancer 19 | 589
Neoplasm Invasiveness 19 | 151
active Crohn's disease 18 | 882
medulloblastoma 18 | 702
non primary Sjogren syndrome sicca 18 | 861
pancreatic carcinoma 18 | 555
Osteoporosis 17 | 348
fibroadenoma 17 | 538
mucosa-associated lymphoid tissue lymphoma 17 | 473
Atopic dermatitis 16 | 915
Carcinoma, Squamous Cell 16 | 107
Squamous cell carcinoma 16 | 125
primary Sjogren syndrome 16 | 710
Alzheimer's disease 15 | 640
Bipolar Disorder 15 | 646
Dull intelligence 15 | 634
Low intelligence 15 | 634
Mental Retardation 15 | 634
Mental deficiency 15 | 634
Neoplasm Metastasis 15 | 160
Poor school performance 15 | 634
Stomach Neoplasms 15 | 287
active ulcerative colitis 15 | 736
Multiple Sclerosis 14 | 527
Vascular disease 14 | 294
gastric cancer 14 | 445
posterior fossa group A ependymoma 14 | 456
Endometriosis 13 | 521
Obesity 13 | 655
Short stature 13 | 514
acute myeloid leukemia 13 | 760

Tissue

Digestive Tract 293 | 17,369
Skin and soft tissues 293 | 17,230
Blood and immune system 292 | 16,909
Endocrine System 292 | 18,159
Female tissues 292 | 17,400
Male tissues 292 | 17,142
Nervous System 289 | 16,725
Urinary Tract 289 | 16,678
Liver and Pancreas 288 | 16,750
Respiratory system 287 | 16,393
Cardiovascular System 277 | 15,192

Target Family

Non-IDG 228 | 12,091
Enzyme 35 | 4,145
Kinase 28 | 634
Transcription Factor 3 | 1,400
Epigenetic 2 | 242
GPCR 1 | 408
Ion Channel 1 | 344
Transporter 1 | 473

Compartment GO Term

Anchoring junction 299 | 299
cellular_component 17,863 | 17,863
Cell 15,779 | 15,779
Cell part 15,778 | 15,778
Intracellular 13,764 | 13,764
Intracellular part 13,630 | 13,630
Organelle 11,921 | 11,921
Intracellular organelle 11,712 | 11,712
membrane-bounded organelle 10,823 | 10,823
Cytoplasm 10,720 | 10,720
Intracellular membrane-bounded... 10,057 | 10,057
Cytoplasmic part 9,029 | 9,029
Organelle part 8,755 | 8,755
Intracellular organelle part 8,566 | 8,566
Membrane 8,335 | 8,335
Nucleus 7,336 | 7,336
Cytosol 6,551 | 6,551
Membrane part 6,403 | 6,403
Plasma membrane 5,682 | 5,682
Macromolecular complex 5,345 | 5,345
Intrinsic component of membran... 5,320 | 5,320
Cell periphery 5,248 | 5,248
Integral component of membrane 5,197 | 5,197
Nucleoplasm 4,931 | 4,931
Intracellular organelle lumen 4,923 | 4,923
Organelle lumen 4,923 | 4,923
membrane-enclosed lumen 4,923 | 4,923
Nuclear part 4,169 | 4,169
Endomembrane system 4,108 | 4,108
Intracellular non-membrane-bou... 3,917 | 3,917
non-membrane-bounded organelle 3,917 | 3,917
Nuclear lumen 3,851 | 3,851
Protein complex 3,565 | 3,565
Organelle membrane 2,798 | 2,798
Extracellular region 2,600 | 2,600
Plasma membrane part 2,531 | 2,531
Vesicle 2,280 | 2,280
Cytoplasmic vesicle 2,158 | 2,158
Intracellular vesicle 2,157 | 2,157
Cytoskeleton 2,084 | 2,084
Bounding membrane of organelle 1,924 | 1,924
Endoplasmic reticulum 1,922 | 1,922
Golgi apparatus 1,884 | 1,884
Intrinsic component of plasma ... 1,701 | 1,701
Integral component of plasma m... 1,647 | 1,647
Cytoskeletal part 1,613 | 1,613
Catalytic complex 1,592 | 1,592
Vesicles 1,566 | 1,566
Mitochondrion 1,557 | 1,557
Extracellular region part 1,533 | 1,533
Cell projection 1,524 | 1,524
Whole membrane 1,521 | 1,521
Cytoplasmic vesicle part 1,468 | 1,468
Endoplasmic reticulum part 1,315 | 1,315
GO:0031975 1,139 | 1,139
Organelle envelope 1,131 | 1,131
Microtubule cytoskeleton 1,127 | 1,127
Nucleoplasm part 1,100 | 1,100
Nuclear outer membrane-endopla... 1,094 | 1,094
Endoplasmic reticulum membrane 1,076 | 1,076
Extracellular space 1,059 | 1,059
Mitochondrial part 1,027 | 1,027
Chromosome 1,020 | 1,020
Mitochondria 985 | 985
Neuron part 958 | 958
Supramolecular polymer 950 | 950
Cell junction 949 | 949
Supramolecular complex 949 | 949
Supramolecular fiber 942 | 942
Secretory vesicle 930 | 930
Golgi apparatus part 923 | 923
Nucleoli 923 | 923
Nucleolus 916 | 916
Endosome 915 | 915
Chromosomal part 872 | 872
GO:0098796 868 | 868
Ribonucleoprotein complex 845 | 845
Cell projection part 838 | 838
Transferase complex 837 | 837
Intracellular ribonucleoprotei... 830 | 830
Plasma membrane region 826 | 826
Secretory granule 810 | 810
Cell surface 805 | 805
Vesicle membrane 786 | 786
Cytoplasmic vesicle membrane 780 | 780
Polymeric cytoskeletal fiber 753 | 753
Mitochondrial envelope 739 | 739
Golgi membrane 715 | 715
Microtubule organizing center 712 | 712
Nuclear body 708 | 708
Vacuole 708 | 708
Neuron projection 701 | 701
Mitochondrial membrane 689 | 689
Centrosome 685 | 685
Extracellular matrix 670 | 670
Receptor complex 670 | 670
Synapse 656 | 656
Lysosome 600 | 600
Lytic vacuole 600 | 600
Endosomal part 554 | 554
Chromatin 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Junctional protein associated with coronary artery disease JCAD Tbio Non-IDG -0.81180 6.70 18
Vinculin VCL Tbio Non-IDG -3.34872 2107.1 637
Afadin AFDN Tbio Non-IDG -2.16280 151.2 200
Tyrosine-protein kinase Fes/Fps FES Tchem Kinase -3.05038 1109.2 314
Plectin PLEC Tbio Non-IDG -2.50749 337.2 130
Rho-related GTP-binding protein RhoU RHOU Tbio Enzyme -1.30084 24.8 95
Pleckstrin homology domain-containing family A member 7 PLEKHA7 Tbio Non-IDG -0.97160 13.3 46
Claudin-5 CLDN5 Tbio Non-IDG -2.58968 349.4 300
Calmodulin-regulated spectrin-associated protein 3 CAMSAP3 Tbio Non-IDG -1.12695 12.1 67
Rho GTPase-activating protein 31 ARHGAP31 Tbio Enzyme -1.00789 13.9 17