Development Level

Tbio 398 | 11,651
Tchem 62 | 1,388
Tdark 38 | 6,593
Tclin 23 | 612

Collection

RFA-RM-18-021 5 | 328
Ion Channel: IDG Consortium (T... 3 | 99
Kinase: IDG Consortium (Target... 2 | 125
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 45 | 979
preweaning lethality, incomple... 23 | 499
embryonic lethality prior to t... 15 | 278
abnormal behavior 12 | 298
abnormal embryo size 12 | 220
decreased body weight 11 | 161
embryonic lethality prior to o... 9 | 239
hyperactivity 9 | 148
abnormal bone structure 8 | 187
abnormal behavioral response t... 7 | 66
decreased vertical activity 7 | 208
embryonic growth retardation 7 | 106
enlarged heart 7 | 210
hypoactivity 7 | 132
increased lean body mass 7 | 172
abnormal retina morphology 6 | 71
abnormal sleep behavior 6 | 70
improved glucose tolerance 6 | 79
cataract 5 | 92
decreased bone mineral content 5 | 151
decreased caudal vertebrae num... 5 | 53
decreased circulating LDL chol... 5 | 38
decreased grip strength 5 | 116
decreased mean corpuscular vol... 5 | 79
decreased startle reflex 5 | 75
decreased total body fat amoun... 5 | 207
edema 5 | 59
increased circulating alkaline... 5 | 122
increased total body fat amoun... 5 | 134
pallor 5 | 34
short tibia 5 | 97
abnormal coat-hair pigmentatio... 4 | 64
abnormal heart morphology 4 | 162
abnormal lens morphology 4 | 81
decreased circulating HDL chol... 4 | 68
decreased circulating alanine ... 4 | 47
decreased circulating choleste... 4 | 93
decreased circulating fructosa... 4 | 30
decreased circulating glucose ... 4 | 126
decreased circulating serum al... 4 | 82
decreased leukocyte cell numbe... 4 | 73
increased blood urea nitrogen ... 4 | 48
increased body weight 4 | 25
increased heart weight 4 | 62
increased or absent threshold ... 4 | 101
increased startle reflex 4 | 112
prenatal lethality prior to he... 4 | 87
small superior vagus ganglion 4 | 74
abnormal bone mineralization 3 | 38
abnormal coat appearance 3 | 31
abnormal cornea morphology 3 | 31
abnormal eye morphology 3 | 68
abnormal locomotor activation 3 | 16
abnormal motor learning 3 | 3
abnormal pericardium morpholog... 3 | 26
abnormal placenta size 3 | 20
abnormal seminal vesicle morph... 3 | 114
abnormal skin morphology 3 | 50
absent startle reflex 3 | 24
convulsive seizures 3 | 13
decreased blood urea nitrogen ... 3 | 51
decreased bone mineral density 3 | 126
decreased circulating amylase ... 3 | 28
decreased circulating aspartat... 3 | 34
decreased circulating creatini... 3 | 39
decreased circulating total pr... 3 | 49
decreased lean body mass 3 | 135
decreased prepulse inhibition 3 | 82
enlarged kidney 3 | 14
increased body length 3 | 32
increased circulating calcium ... 3 | 34
increased circulating chloride... 3 | 41
increased circulating phosphat... 3 | 26
increased circulating sodium l... 3 | 71
increased fasted circulating g... 3 | 76
increased mean corpuscular vol... 3 | 92
limb grasping 3 | 41
prolonged ST segment 3 | 36
abnormal gait 2 | 69
abnormal retinal inner nuclear... 2 | 8
abnormal vibrissa morphology 2 | 25
abnormal vocalization 2 | 21
cardiovascular system phenotyp... 2 | 36
corneal opacity 2 | 32
decreased body length 2 | 101
decreased circulating calcium ... 2 | 36
decreased circulating free fat... 2 | 31
decreased circulating triglyce... 2 | 79
decreased hematocrit 2 | 46
decreased neutrophil cell numb... 2 | 42
decreased spleen weight 2 | 10
increased bone mineral content 2 | 108
increased bone mineral density 2 | 72
increased circulating iron lev... 2 | 30
increased circulating total pr... 2 | 28
increased circulating triglyce... 2 | 42
increased hemoglobin content 2 | 45
increased mean corpuscular hem... 2 | 96
male infertility 2 | 123
tremors 2 | 39

Disease

Carcinoma 374 | 11,493
ovarian cancer 286 | 8,519
osteosarcoma 269 | 7,950
psoriasis 236 | 6,694
glioblastoma 234 | 5,792
medulloblastoma, large-cell 200 | 6,241
atypical teratoid / rhabdoid tumor 187 | 5,112
lung cancer 180 | 4,740
ependymoma 179 | 4,679
Cancer 177 | 2,499
Breast cancer 158 | 3,577
adult high grade glioma 146 | 3,801
malignant mesothelioma 146 | 3,232
Kidney cancer 145 | 2,613
pancreatic cancer 145 | 2,398
Astrocytoma, Pilocytic 142 | 3,081
intraductal papillary-mucinous neoplasm (IPMN) 139 | 3,290
invasive ductal carcinoma 134 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 127 | 2,954
group 3 medulloblastoma 126 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 126 | 2,988
non-small cell lung cancer 124 | 2,890
primitive neuroectodermal tumor 121 | 3,035
lung carcinoma 114 | 2,843
diabetes mellitus 113 | 1,728
lung adenocarcinoma 109 | 2,716
subependymal giant cell astrocytoma 109 | 2,287
oligodendroglioma 103 | 2,850
astrocytic glioma 96 | 2,597
ductal carcinoma in situ 90 | 1,744
breast carcinoma 87 | 1,637
group 4 medulloblastoma 85 | 1,855
cystic fibrosis 81 | 1,695
interstitial cystitis 81 | 2,312
acute quadriplegic myopathy 80 | 1,158
primary pancreatic ductal adenocarcinoma 79 | 1,108
colon cancer 78 | 1,478
ulcerative colitis 78 | 1,819
pituitary cancer 76 | 1,972
tuberculosis 76 | 2,010
Autosomal recessive predisposition 69 | 1,442
Schizophrenia 68 | 1,160
juvenile dermatomyositis 66 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 65 | 1,962
Liver Cirrhosis, Experimental 63 | 769
adrenocortical carcinoma 63 | 1,428
Duchenne muscular dystrophy 59 | 601
Heart disease 58 | 306
Kidney disease 57 | 430
Pick disease 55 | 1,894
spina bifida 53 | 1,074
Alzheimer's disease 52 | 658
Hypertension 52 | 396
autosomal dominant Emery-Dreifuss muscular dystrophy 52 | 510
Rheumatoid arthritis 50 | 1,191
astrocytoma 48 | 1,146
Melanoma 47 | 711
pediatric high grade glioma 47 | 1,064
dermatomyositis 46 | 966
Liver cancer 45 | 604
Cerebrovascular disease 44 | 238
gastric carcinoma 42 | 807
Myopathy 41 | 185
cutaneous lupus erythematosus 41 | 1,057
Breast Neoplasms 39 | 445
Coronary artery disease 39 | 268
Obesity 39 | 678
Bipolar Disorder 38 | 666
Multiple myeloma 38 | 1,332
Intellectual disability 37 | 1,016
Mammary Neoplasms 37 | 425
Skin cancer 37 | 469
Waldenstrons macroglobulinemia 37 | 765
esophageal adenocarcinoma 37 | 737
Atherosclerosis 36 | 291
Osteoporosis 36 | 363
Neoplasm Metastasis 35 | 168
Amyotrophic lateral sclerosis 34 | 451
Neoplasm Invasiveness 34 | 161
Down syndrome 33 | 499
Hypertensive disease 33 | 292
nasopharyngeal carcinoma 32 | 1,058
non primary Sjogren syndrome sicca 32 | 891
Carcinoma, Hepatocellular 31 | 228
Liver carcinoma 31 | 240
Lung disease 31 | 142
Neuropathy 31 | 261
Prostatic Neoplasms 31 | 495
Stomach Neoplasms 31 | 300
Atopic dermatitis 30 | 952
Vascular disease 30 | 319
fibroadenoma 30 | 559
pancreatic carcinoma 30 | 562
Endometrial cancer 29 | 311
Epilepsy 29 | 792
Heart failure 29 | 162
acute myeloid leukemia 29 | 783
Anemia 28 | 365
Arthritis 28 | 290
Endometriosis 28 | 540

Tissue

Endocrine System 513 | 18,159
Digestive Tract 508 | 17,369
Skin and soft tissues 508 | 17,230
Blood and immune system 503 | 16,909
Female tissues 503 | 17,400
Male tissues 500 | 17,142
Liver and Pancreas 497 | 16,750
Urinary Tract 495 | 16,678
Nervous System 491 | 16,725
Respiratory system 482 | 16,393
Cardiovascular System 474 | 15,192

Target Family

Non-IDG 380 | 12,091
Enzyme 69 | 4,145
Kinase 37 | 634
Transcription Factor 21 | 1,400
Ion Channel 5 | 344
Transporter 5 | 473
GPCR 3 | 408
Nuclear Receptor 1 | 48

Compartment GO Term

Actin cytoskeleton 521 | 521
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Myosin-13 MYH13 Tbio Non-IDG -1.26079 16.6 12
Myosin-2 MYH2 Tbio Non-IDG -2.14128 114.9 63
Actin filament-associated protein 1 AFAP1 Tbio Non-IDG -1.89567 70.0 314
Endothelin-1 EDN1 Tbio Non-IDG -4.07520 12851.9 607
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
Myosin light chain kinase, smooth muscle MYLK Tchem Kinase -2.81312 694.0 219
Unconventional myosin-VIIb MYO7B Tbio Non-IDG -0.65885 5.07 14
Spectrin beta chain, non-erythrocytic 5 SPTBN5 Tbio Non-IDG -0.41365 2.99 32
Interleukin-6 IL6 Tclin Non-IDG -4.50976 30968.8 2075