Development Level

Tbio 9 | 11,445
Tchem 3 | 1,598

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal blood vessel morpholo... 2 | 5
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
abnormal chorioallantoic fusio... 1 | 8
abnormal embryo development 1 | 7
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal forebrain development 1 | 20
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal pharyngeal arch morph... 1 | 8
abnormal somite shape 1 | 5
abnormal spinal cord morpholog... 1 | 9
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
cardiovascular system phenotyp... 1 | 36
decreased circulating glucose ... 1 | 126
decreased fasted circulating g... 1 | 65
decreased heart rate variabili... 1 | 13
embryonic growth retardation 1 | 106
increased circulating sodium l... 1 | 71
pale yolk sac 1 | 25
pallor 1 | 34
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36

Disease

Carcinoma 11 | 11,493
lung cancer 7 | 4,740
Cancer 6 | 2,499
ovarian cancer 6 | 8,520
Kidney cancer 5 | 2,613
malignant mesothelioma 5 | 3,232
Ataxia telangiectasia 4 | 34
Breast cancer 4 | 3,578
Seckel syndrome 4 | 34
colon cancer 4 | 1,478
group 3 medulloblastoma 4 | 4,104
osteosarcoma 4 | 7,950
Autosomal recessive predisposition 3 | 1,442
Bloom syndrome 3 | 29
Cataract 3 | 297
Epilepsy 3 | 792
Intellectual disability 3 | 1,016
Microcephaly 3 | 166
Nijmegen breakage syndrome 3 | 24
Seizures 3 | 596
Short stature 3 | 531
Strabismus 3 | 270
Telangiectasis 3 | 36
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
non-small cell lung cancer 3 | 2,890
Age related macular degeneration 2 | 72
Angle class 2 malocclusion 2 | 57
Angle class 3 malocclusion 2 | 57
Arthrogryposis syndrome 2 | 3
Auricular malformation 2 | 41
Blepharophimosis 2 | 70
Breast Neoplasms 2 | 445
COFS syndrome 2 | 5
Cerebellar Ataxia 2 | 304
Cerebro-oculo-facio-skeletal syndrome 2 | 4
Choreoathetoid movements 2 | 32
Choreoathetosis 2 | 32
Chronic Lymphocytic Leukemia 2 | 262
Cockayne Syndrome, Type 3 2 | 3
Cockayne syndrome 2 | 60
Cockayne syndrome B 2 | 2
Cryptorchidism 2 | 296
De Sanctis-Cacchione Syndrome 2 | 2
Decreased to absent deep tendon reflexes 2 | 42
Dental caries 2 | 164
Dull intelligence 2 | 645
Fanconi anemia 2 | 56
Fetal Growth Retardation 2 | 189
Fibroma 2 | 18
Flexion contracture - elbow 2 | 32
Hair shaft abnormalities 2 | 30
Hypoplastic mandible condyle 2 | 275
Infant, Small for Gestational Age 2 | 176
Intrauterine retardation 2 | 176
Leukemia, Lymphocytic, Chronic, B-Cell 2 | 34
Low intelligence 2 | 645
Malocclusion 2 | 57
Mammary Neoplasms 2 | 425
Mandibular hypoplasia 2 | 275
Mental Retardation 2 | 645
Mental deficiency 2 | 645
Micrognathism 2 | 275
Muscle Spasticity 2 | 195
Nystagmus 2 | 317
Ossifying fibroma 2 | 15
Photosensitive trichothiodystrophy 2 | 30
Pick disease 2 | 1,894
Poor school performance 2 | 645
Postnatal growth retardation 2 | 57
Prostatic Neoplasms 2 | 495
Rotting teeth 2 | 73
Schizophrenia 2 | 1,160
Simple ear 2 | 41
Sloping forehead 2 | 46
Small head 2 | 374
Spider Veins 2 | 17
Splenomegaly 2 | 190
Tremor 2 | 113
UV-sensitive syndrome 2 | 10
acute quadriplegic myopathy 2 | 1,158
atypical teratoid / rhabdoid tumor 2 | 5,112
diabetes mellitus 2 | 1,728
ependymoma 2 | 4,679
glioblastoma 2 | 5,792
hair abnormalities (non-specific) 2 | 30
locked-in syndrome 2 | 14
medulloblastoma, large-cell 2 | 6,241
non primary Sjogren syndrome sicca 2 | 891
pancreatic cancer 2 | 2,398
psoriasis 2 | 6,694
ulcerative colitis 2 | 1,819
Hypoplastic pelvis 1 | 9
Increased size of palpebral fissures 1 | 9
Large eyes 1 | 9
Photosensitivity of skin 1 | 51
Poikiloderma 1 | 14
Precociously senile appearance 1 | 18
Premature canities 1 | 24
Slender nose 1 | 3
Tooth hypoplasia 1 | 7

Tissue

Blood and immune system 11 | 16,909
Digestive Tract 11 | 17,369
Endocrine System 11 | 18,159
Female tissues 11 | 17,400
Liver and Pancreas 11 | 16,750
Male tissues 11 | 17,142
Nervous System 11 | 16,725
Respiratory system 11 | 16,393
Skin and soft tissues 11 | 17,230
Urinary Tract 11 | 16,678
Cardiovascular System 10 | 15,192

Target Family

Non-IDG 8 | 12,091
Kinase 3 | 634
Enzyme 1 | 4,145

Compartment GO Term

ATR-ATRIP complex 12 | 12
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,784 | 8,784
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,932 | 1,932
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,641 | 1,641
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 970 | 970
Neuron part 969 | 969
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 950 | 950
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 711 | 711
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein kinase Chk1 CHEK1 Tchem Kinase -3.04423 1089.6 1375
Serine-protein kinase ATM ATM Tchem Kinase -3.57054 3681.6 1024
Cell cycle checkpoint control protein RAD9A RAD9A Tbio Non-IDG -2.15330 141.0 919
Cell cycle checkpoint protein RAD17 RAD17 Tbio Non-IDG -2.06551 113.6 482
Serine/threonine-protein kinase ATR ATR Tchem Kinase -2.80362 549.6 376
ATR-interacting protein ATRIP Tbio Non-IDG -1.60828 43.0 359
DNA topoisomerase 2-binding protein 1 TOPBP1 Tbio Enzyme -2.04312 118.0 230
Checkpoint protein HUS1 HUS1 Tbio Non-IDG -1.87625 67.8 180
DNA excision repair protein ERCC-6 ERCC6 Tbio Non-IDG -2.31776 361.5 163
Claspin CLSPN Tbio Non-IDG -1.76624 62.6 74