Development Level

Tbio 147 | 11,651
Tchem 84 | 1,388
Tdark 74 | 6,593
Tclin 23 | 612

Collection

RFA-RM-18-021 328 | 328
GPCR: IDG Consortium (Targets) 126 | 126
Kinase: IDG Consortium (Target... 125 | 125
Ion Channel: IDG Consortium (T... 99 | 99
Kinase: IDG Consortium (Comple... 37 | 37
GPCR: IDG Consortium (Complete... 25 | 25

IMPC Phenotype

preweaning lethality, incomple... 9 | 499
preweaning lethality, complete... 8 | 979
abnormal behavior 6 | 298
decreased vertical activity 6 | 208
abnormal bone structure 5 | 187
decreased circulating glucose ... 5 | 126
hyperactivity 5 | 148
increased bone mineral content 5 | 108
abnormal embryo size 4 | 220
enlarged heart 4 | 210
impaired glucose tolerance 4 | 75
improved glucose tolerance 4 | 79
abnormal seminal vesicle morph... 3 | 114
decreased bone mineral content 3 | 151
decreased bone mineral density 3 | 126
decreased hematocrit 3 | 46
decreased hemoglobin content 3 | 68
decreased mean corpuscular hem... 3 | 50
decreased mean corpuscular vol... 3 | 79
decreased total body fat amoun... 3 | 207
hydrometra 3 | 53
increased circulating sodium l... 3 | 71
increased fasted circulating g... 3 | 76
increased mean corpuscular vol... 3 | 92
small superior vagus ganglion 3 | 74
abnormal behavioral response t... 2 | 66
abnormal epididymis morphology 2 | 42
abnormal gait 2 | 69
abnormal heart morphology 2 | 162
abnormal pelvic girdle bone mo... 2 | 12
abnormal skin coloration 2 | 25
abnormal spleen morphology 2 | 55
decreased eosinophil cell numb... 2 | 24
decreased fasted circulating g... 2 | 65
decreased grip strength 2 | 116
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
decreased startle reflex 2 | 75
embryonic growth retardation 2 | 106
embryonic lethality prior to o... 2 | 239
enlarged epididymis 2 | 31
female infertility 2 | 60
increased bone mineral density 2 | 72
increased circulating HDL chol... 2 | 80
increased circulating choleste... 2 | 66
increased circulating creatini... 2 | 38
increased heart weight 2 | 62
increased lean body mass 2 | 172
increased monocyte cell number 2 | 63
increased or absent threshold ... 2 | 101
increased urine microalbumin l... 2 | 2
male infertility 2 | 123
short tibia 2 | 97
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal embryo turning 1 | 31
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal liver morphology 1 | 17
abnormal snout morphology 1 | 23
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 18
absent pinna reflex 1 | 23
absent teeth 1 | 3
absent vibrissae 1 | 12
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased circulating calcium ... 1 | 36
decreased circulating magnesiu... 1 | 13
decreased circulating serum al... 1 | 82
decreased heart left ventricle... 1 | 28
decreased lean body mass 1 | 135
decreased red blood cell distr... 1 | 41
decreased total retina thickne... 1 | 17
dilated heart left ventricle 1 | 11
embryonic lethality prior to t... 1 | 278
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
enlarged uterus 1 | 11
impaired pupillary reflex 1 | 26
increased circulating alkaline... 1 | 122
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating potassiu... 1 | 29
increased circulating serum al... 1 | 22
increased circulating triglyce... 1 | 42
increased heart rate 1 | 23
increased hemoglobin content 1 | 45
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
increased vertical activity 1 | 24
limb grasping 1 | 41
polycystic kidney 1 | 15
prenatal lethality 1 | 28
shortened PQ interval 1 | 7
small thymus 1 | 16
thin ventricular wall 1 | 24
thrombocytosis 1 | 27
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 233 | 11,493
osteosarcoma 114 | 7,950
psoriasis 110 | 6,694
ovarian cancer 106 | 8,520
medulloblastoma, large-cell 103 | 6,241
ependymoma 96 | 4,679
atypical teratoid / rhabdoid tumor 93 | 5,112
glioblastoma 90 | 5,792
adult high grade glioma 73 | 3,801
Astrocytoma, Pilocytic 61 | 3,081
lung carcinoma 59 | 2,843
oligodendroglioma 59 | 2,850
primitive neuroectodermal tumor 57 | 3,035
lung cancer 56 | 4,740
group 3 medulloblastoma 54 | 4,104
Breast cancer 47 | 3,578
Kidney cancer 45 | 2,613
astrocytic glioma 45 | 2,597
intraductal papillary-mucinous neoplasm (IPMN) 43 | 3,291
malignant mesothelioma 43 | 3,232
intraductal papillary-mucinous adenoma (IPMA) 41 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 40 | 2,989
lung adenocarcinoma 37 | 2,716
group 4 medulloblastoma 36 | 1,855
non-small cell lung cancer 36 | 2,890
interstitial cystitis 35 | 2,312
pituitary cancer 35 | 1,972
Pick disease 34 | 1,894
cystic fibrosis 34 | 1,696
invasive ductal carcinoma 31 | 2,951
pancreatic cancer 28 | 2,398
ulcerative colitis 28 | 1,819
Schizophrenia 27 | 1,160
subependymal giant cell astrocytoma 27 | 2,287
ductal carcinoma in situ 22 | 1,745
tuberculosis 22 | 2,010
breast carcinoma 20 | 1,638
Bipolar Disorder 19 | 666
Multiple Sclerosis 19 | 540
diabetes mellitus 19 | 1,728
pancreatic ductal adenocarcinoma liver metastasis 19 | 1,962
Liver cancer 17 | 604
medulloblastoma 17 | 720
cutaneous lupus erythematosus 15 | 1,057
Eaton-Lambert syndrome 14 | 40
Epilepsy 14 | 792
nasopharyngeal carcinoma 14 | 1,058
pediatric high grade glioma 14 | 1,064
astrocytoma 13 | 1,146
Melanoma 12 | 711
adrenocortical carcinoma 12 | 1,428
primary Sjogren syndrome 12 | 735
Rheumatoid arthritis 11 | 1,191
active Crohn's disease 11 | 922
colon cancer 11 | 1,478
esophageal adenocarcinoma 11 | 737
progressive supranuclear palsy 11 | 676
spina bifida 11 | 1,074
Amyotrophic lateral sclerosis 10 | 451
Atopic dermatitis 10 | 952
Autosomal recessive predisposition 10 | 1,442
Down syndrome 10 | 499
gastric carcinoma 10 | 807
pancreatic carcinoma 10 | 562
Skin cancer 9 | 469
active ulcerative colitis 9 | 764
acute quadriplegic myopathy 9 | 1,158
aldosterone-producing adenoma 9 | 665
fibroadenoma 9 | 559
juvenile dermatomyositis 9 | 1,187
mucosa-associated lymphoid tissue lymphoma 9 | 484
non primary Sjogren syndrome sicca 9 | 891
atypical teratoid/rhabdoid tumor 8 | 357
posterior fossa group B ependymoma 8 | 416
Duchenne muscular dystrophy 7 | 601
Intellectual disability 7 | 1,016
Obesity 7 | 678
Renal Cell Carcinoma 7 | 214
primary pancreatic ductal adenocarcinoma 7 | 1,109
sarcoidosis 7 | 370
Alcoholic Intoxication, Chronic 6 | 289
Alzheimer's disease 6 | 658
Gastrointestinal stromal tumor 6 | 62
Multiple myeloma 6 | 1,332
Pancreatic Neuroendocrine Tumor 6 | 45
Psychotic Disorders 6 | 151
chronic rhinosinusitis 6 | 512
cystic fibrosis and chronic rhinosinusitis 6 | 214
facioscapulohumeral dystrophy 6 | 288
glioblastoma multiforme 6 | 142
non-small cell lung carcinoma 6 | 317
sonic hedgehog group medulloblastoma 6 | 467
Cancer 5 | 2,499
Muscle hypotonia 5 | 571
Seizures 5 | 596
acute myeloid leukemia 5 | 783
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 510
dermatomyositis 5 | 966
hepatocellular carcinoma 5 | 547
hereditary spastic paraplegia 5 | 318

Tissue

Endocrine System 305 | 18,159
Female tissues 291 | 17,400
Digestive Tract 287 | 17,369
Skin and soft tissues 287 | 17,230
Male tissues 282 | 17,142
Nervous System 282 | 16,725
Blood and immune system 270 | 16,909
Liver and Pancreas 267 | 16,750
Urinary Tract 262 | 16,678
Respiratory system 259 | 16,393
Cardiovascular System 231 | 15,192

Target Family

Kinase 125 | 634
GPCR 102 | 408
Ion Channel 101 | 344

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