Development Level

Tchem 67 | 1,598
Tbio 40 | 11,445
Tdark 18 | 6,588

Collection

Kinase: IDG Consortium (Target... 125 | 125
GPCR: IDG Consortium (Targets) 126 | 126
Ion Channel: IDG Consortium (T... 99 | 99
Kinase: IDG Consortium (Comple... 37 | 37
GPCR: IDG Consortium (Complete... 25 | 25

IMPC Phenotype

preweaning lethality, incomple... 7 | 499
preweaning lethality, complete... 5 | 979
increased bone mineral content 4 | 108
abnormal embryo size 3 | 220
decreased circulating glucose ... 3 | 126
enlarged heart 3 | 210
abnormal behavioral response t... 2 | 66
abnormal bone structure 2 | 187
abnormal spleen morphology 2 | 55
decreased hematocrit 2 | 46
decreased hemoglobin content 2 | 68
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular hem... 2 | 50
decreased mean corpuscular vol... 2 | 79
decreased vertical activity 2 | 208
embryonic lethality prior to o... 2 | 239
improved glucose tolerance 2 | 79
increased bone mineral density 2 | 72
increased circulating HDL chol... 2 | 80
increased circulating choleste... 2 | 66
increased mean corpuscular vol... 2 | 92
increased monocyte cell number 2 | 63
male infertility 2 | 123
abnormal behavior 1 | 298
abnormal cecum morphology 1 | 7
abnormal clavicle morphology 1 | 6
abnormal cranium morphology 1 | 36
abnormal epididymis morphology 1 | 42
abnormal eyelid morphology 1 | 7
abnormal femur morphology 1 | 14
abnormal fibula morphology 1 | 2
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal heart shape 1 | 5
abnormal humerus morphology 1 | 11
abnormal joint morphology 1 | 23
abnormal locomotor behavior 1 | 24
abnormal mandible morphology 1 | 2
abnormal maxilla morphology 1 | 17
abnormal pelvic girdle bone mo... 1 | 12
abnormal radius morphology 1 | 8
abnormal rib morphology 1 | 10
abnormal seminal vesicle morph... 1 | 114
abnormal snout morphology 1 | 23
abnormal testis morphology 1 | 43
abnormal tibia morphology 1 | 14
abnormal tooth morphology 1 | 24
abnormal ulna morphology 1 | 8
abnormal vertebrae morphology 1 | 18
absent teeth 1 | 3
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral content 1 | 151
decreased cardiac muscle contr... 1 | 11
decreased circulating alkaline... 1 | 46
decreased circulating magnesiu... 1 | 13
decreased circulating serum al... 1 | 82
decreased eosinophil cell numb... 1 | 24
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased lean body mass 1 | 135
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
decreased total retina thickne... 1 | 17
dilated heart left ventricle 1 | 11
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged epididymis 1 | 31
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
hydrometra 1 | 53
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
impaired pupillary reflex 1 | 26
increased caudal vertebrae num... 1 | 7
increased circulating LDL chol... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating calcium ... 1 | 34
increased circulating potassiu... 1 | 29
increased circulating sodium l... 1 | 71
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased or absent threshold ... 1 | 101
increased red blood cell distr... 1 | 34
increased spleen weight 1 | 10
megacolon 1 | 2
pallor 1 | 34
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
small superior vagus ganglion 1 | 74
small testis 1 | 58
small thymus 1 | 16
thick ventricular wall 1 | 7
thin ventricular wall 1 | 24
thrombocytosis 1 | 27
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 98 | 11,493
ovarian cancer 60 | 8,520
osteosarcoma 55 | 7,950
medulloblastoma, large-cell 47 | 6,241
psoriasis 42 | 6,694
ependymoma 41 | 4,679
glioblastoma 39 | 5,792
atypical teratoid / rhabdoid tumor 36 | 5,112
adult high grade glioma 29 | 3,801
oligodendroglioma 24 | 2,850
primitive neuroectodermal tumor 24 | 3,035
group 4 medulloblastoma 23 | 1,855
lung cancer 23 | 4,740
Astrocytoma, Pilocytic 22 | 3,081
astrocytic glioma 20 | 2,597
group 3 medulloblastoma 20 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 20 | 3,291
Kidney cancer 19 | 2,613
Breast cancer 18 | 3,578
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,989
Pick disease 17 | 1,894
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,955
malignant mesothelioma 17 | 3,232
lung carcinoma 16 | 2,843
non-small cell lung cancer 14 | 2,890
pituitary cancer 14 | 1,972
cystic fibrosis 13 | 1,696
invasive ductal carcinoma 13 | 2,951
ulcerative colitis 13 | 1,819
pancreatic cancer 12 | 2,398
diabetes mellitus 11 | 1,728
lung adenocarcinoma 11 | 2,716
tuberculosis 10 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
subependymal giant cell astrocytoma 9 | 2,287
Liver cancer 8 | 604
Down syndrome 7 | 499
Renal Cell Carcinoma 7 | 214
Rheumatoid arthritis 7 | 1,191
interstitial cystitis 7 | 2,312
medulloblastoma 7 | 720
Amyotrophic lateral sclerosis 6 | 451
Gastrointestinal stromal tumor 6 | 62
Melanoma 6 | 711
Pancreatic Neuroendocrine Tumor 6 | 45
Schizophrenia 6 | 1,160
acute quadriplegic myopathy 6 | 1,158
aldosterone-producing adenoma 6 | 665
pediatric high grade glioma 6 | 1,064
progressive supranuclear palsy 6 | 676
Multiple myeloma 5 | 1,332
adrenocortical carcinoma 5 | 1,428
astrocytoma 5 | 1,146
colon cancer 5 | 1,478
cutaneous lupus erythematosus 5 | 1,057
dermatomyositis 5 | 966
ductal carcinoma in situ 5 | 1,745
juvenile dermatomyositis 5 | 1,187
pancreatic carcinoma 5 | 562
spina bifida 5 | 1,074
Alzheimer's disease 4 | 658
Chronic Lymphocytic Leukemia 4 | 262
Epilepsy 4 | 792
Gaucher disease type 1 4 | 180
Hamman-Rich syndrome 4 | 34
Meckel syndrome 4 | 46
Neurodegenerative disease 4 | 414
atypical teratoid/rhabdoid tumor 4 | 357
posterior fossa group B ependymoma 4 | 416
primary Sjogren syndrome 4 | 735
primary pancreatic ductal adenocarcinoma 4 | 1,109
sarcoidosis 4 | 370
sonic hedgehog group medulloblastoma 4 | 467
Acquired metabolic disease 3 | 336
Autosomal recessive predisposition 3 | 1,442
Azoospermia 3 | 110
Bipolar Disorder 3 | 666
Cancer 3 | 2,499
Crohn's disease 3 | 321
Duchenne muscular dystrophy 3 | 601
Intellectual disability 3 | 1,016
Obesity 3 | 678
Oligospermia 3 | 36
Parkinson's disease 3 | 392
Psychotic Disorders 3 | 151
Skin cancer 3 | 469
Waldenstrons macroglobulinemia 3 | 765
Western equine encephalitis 3 | 13
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 510
breast carcinoma 3 | 1,638
chronic rhinosinusitis 3 | 512
cystic fibrosis and chronic rhinosinusitis 3 | 214
fibroadenoma 3 | 559
gastric carcinoma 3 | 807
hepatocellular carcinoma 3 | 547
hereditary spastic paraplegia 3 | 318
nasopharyngeal carcinoma 3 | 1,058
tuberculosis and treatment for 6 months 3 | 409
Arthritis, Rheumatoid 2 | 174
periodontitis 2 | 293

Tissue

Endocrine System 123 | 18,159
Male tissues 120 | 17,142
Skin and soft tissues 120 | 17,230
Digestive Tract 119 | 17,369
Liver and Pancreas 119 | 16,750
Female tissues 118 | 17,400
Nervous System 116 | 16,725
Urinary Tract 116 | 16,678
Respiratory system 115 | 16,393
Blood and immune system 113 | 16,909
Cardiovascular System 111 | 15,192

Target Family

Kinase 125 | 634

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Casein kinase II subunit alpha' CSNK2A2 Tchem Kinase -2.34168 221.3 218
Calcium/calmodulin-dependent protein kinase type 1B PNCK Tbio Kinase -2.14753 82.1 161
Serine/threonine-protein kinase SBK1 SBK1 Tchem Kinase -1.79211 61.1 17
N-terminal kinase-like protein SCYL1 Tbio Kinase -1.71351 53.9 138
Dual specificity tyrosine-phosphorylation-regulated kinase 1B DYRK1B Tchem Kinase -1.63295 52.7 289
Serine/threonine-protein kinase PAK 6 PAK6 Tchem Kinase -1.57638 44.4 402
MAP/microtubule affinity-regulating kinase 4 MARK4 Tchem Kinase -1.59105 42.6 285
CaM kinase-like vesicle-associated protein CAMKV Tbio Kinase -1.63536 42.6 153
Serine/threonine-protein kinase 32C STK32C Tbio Kinase -1.64571 41.9 94
Serine/threonine-protein kinase Nek6 NEK6 Tchem Kinase -1.53724 36.6 188