Development Level

Tbio 46 | 11,445
Tclin 24 | 613
Tdark 15 | 6,588
Tchem 14 | 1,598

Collection

Ion Channel: IDG Consortium (T... 99 | 99
RFA-RM-18-021 328 | 328
GPCR: IDG Consortium (Targets) 126 | 126
Kinase: IDG Consortium (Target... 125 | 125
Kinase: IDG Consortium (Comple... 37 | 37
GPCR: IDG Consortium (Complete... 25 | 25

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal behavior 2 | 298
decreased vertical activity 2 | 208
hydrometra 2 | 53
impaired glucose tolerance 2 | 75
small superior vagus ganglion 2 | 74
abnormal bone structure 1 | 187
abnormal brain morphology 1 | 13
abnormal cornea morphology 1 | 31
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal lens morphology 1 | 81
abnormal pelvic girdle bone mo... 1 | 12
abnormal seminal vesicle morph... 1 | 114
decreased body length 1 | 101
decreased cardiac stroke volum... 1 | 6
decreased circulating calcium ... 1 | 36
decreased circulating free fat... 1 | 31
decreased circulating glucose ... 1 | 126
decreased fasted circulating g... 1 | 65
decreased red blood cell distr... 1 | 41
embryonic growth retardation 1 | 106
enlarged uterus 1 | 11
female infertility 1 | 60
fusion of vertebral arches 1 | 7
hydroencephaly 1 | 14
hyperactivity 1 | 148
improved glucose tolerance 1 | 79
increased circulating alkaline... 1 | 122
increased circulating creatini... 1 | 38
increased circulating serum al... 1 | 22
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased heart rate 1 | 23
increased mean corpuscular vol... 1 | 92
increased startle reflex 1 | 112
limb grasping 1 | 41
polysyndactyly 1 | 2
shortened PQ interval 1 | 7
shortened PR interval 1 | 6
shortened QT interval 1 | 4
shortened ST segment 1 | 10
vertebral transformation 1 | 12

Disease

Carcinoma 68 | 11,493
atypical teratoid / rhabdoid tumor 38 | 5,112
ependymoma 38 | 4,679
medulloblastoma, large-cell 36 | 6,241
psoriasis 35 | 6,694
osteosarcoma 34 | 7,950
glioblastoma 32 | 5,792
Astrocytoma, Pilocytic 31 | 3,081
adult high grade glioma 30 | 3,801
ovarian cancer 27 | 8,520
group 3 medulloblastoma 26 | 4,104
oligodendroglioma 26 | 2,850
lung carcinoma 25 | 2,843
primitive neuroectodermal tumor 22 | 3,035
astrocytic glioma 20 | 2,597
Pick disease 18 | 1,894
lung cancer 18 | 4,740
Multiple Sclerosis 16 | 540
intraductal papillary-mucinous adenoma (IPMA) 16 | 2,955
Kidney cancer 15 | 2,613
Eaton-Lambert syndrome 14 | 40
Schizophrenia 14 | 1,160
cystic fibrosis 14 | 1,696
lung adenocarcinoma 14 | 2,716
malignant mesothelioma 14 | 3,232
Bipolar Disorder 13 | 666
non-small cell lung cancer 13 | 2,890
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
subependymal giant cell astrocytoma 12 | 2,287
Breast cancer 11 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
pituitary cancer 11 | 1,972
Epilepsy 10 | 792
interstitial cystitis 10 | 2,312
pancreatic cancer 9 | 2,398
nasopharyngeal carcinoma 8 | 1,058
ductal carcinoma in situ 7 | 1,745
invasive ductal carcinoma 7 | 2,951
ulcerative colitis 7 | 1,819
Autosomal recessive predisposition 6 | 1,442
General anesthesia 6 | 53
active Crohn's disease 6 | 922
active ulcerative colitis 6 | 764
group 4 medulloblastoma 6 | 1,855
medulloblastoma 6 | 720
Atopic dermatitis 5 | 952
Autistic Disorder 5 | 364
Liver cancer 5 | 604
Tonic-clonic epilepsy 5 | 47
breast carcinoma 5 | 1,638
cutaneous lupus erythematosus 5 | 1,057
non primary Sjogren syndrome sicca 5 | 891
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
progressive supranuclear palsy 5 | 676
Alcoholic Intoxication, Chronic 4 | 289
Gastroesophageal reflux disease 4 | 110
Mental Depression 4 | 333
Muscle hypotonia 4 | 571
Nicotine dependence 4 | 54
Seizures 4 | 596
Skin cancer 4 | 469
colon cancer 4 | 1,478
esophageal adenocarcinoma 4 | 737
fibroadenoma 4 | 559
gastric carcinoma 4 | 807
pediatric high grade glioma 4 | 1,064
Amyotrophic lateral sclerosis 3 | 451
Anxiety 3 | 136
Brugada syndrome 3 | 29
Chemotherapy-induced nausea and vomiting 3 | 16
Depressive disorder 3 | 409
Diabetic gastroparesis 3 | 7
Edema 3 | 81
Episodic ataxia 3 | 22
Failure to gain weight 3 | 365
Gastrointestinal Radiography Adjunct 3 | 11
Infantile onset 3 | 238
Insomnia 3 | 20
Intellectual disability 3 | 1,016
Intubation of gastrointestinal tract 3 | 7
Irritable bowel syndrome 3 | 60
Melanoma 3 | 711
Pediatric failure to thrive 3 | 365
Prenatal onset 3 | 139
Prevention of Post-Operative Nausea and Vomiting 3 | 14
Schizoaffective Disorder 3 | 55
adrenocortical carcinoma 3 | 1,428
astrocytoma 3 | 1,146
cystic fibrosis and chronic rhinosinusitis 3 | 214
glioblastoma multiforme 3 | 142
head and neck cancer 3 | 271
pancreatic carcinoma 3 | 562
posterior fossa group B ependymoma 3 | 416
primary Sjogren syndrome 3 | 735
tuberculosis 3 | 2,010
Diarrhea 2 | 253
Neuropathy 2 | 261
Renal Insufficiency 2 | 90
Renal failure in adulthood 2 | 76
hereditary spastic paraplegia 2 | 318

Tissue

Endocrine System 96 | 18,159
Female tissues 90 | 17,400
Nervous System 90 | 16,725
Digestive Tract 89 | 17,369
Skin and soft tissues 87 | 17,230
Male tissues 86 | 17,142
Blood and immune system 83 | 16,909
Urinary Tract 80 | 16,678
Liver and Pancreas 79 | 16,750
Respiratory system 78 | 16,393
Cardiovascular System 60 | 15,192

Target Family

Ion Channel 99 | 344

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Gamma-aminobutyric acid receptor subunit alpha-5 GABRA5 Tclin Ion Channel -1.57578 34.2 189
Acid-sensing ion channel 4 ASIC4 Tbio Ion Channel -1.16480 13.1 113
Bestrophin-4 BEST4 Tbio Ion Channel -1.41141 24.9 75
Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 Tclin Ion Channel -1.59683 37.4 101
Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 Tbio Ion Channel -1.04402 13.0 72
Voltage-dependent calcium channel subunit alpha-2/delta-4 CACNA2D4 Tbio Ion Channel -1.62494 44.1 133
Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 Tbio Ion Channel -0.90841 6.64 294
Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 Tbio Ion Channel -1.46356 25.4 471
Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 Tbio Ion Channel -1.16723 13.5 158
Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 Tbio Ion Channel -1.56337 35.6 234