Development Level

Tbio 118 | 11,445
Tclin 25 | 613
Tchem 23 | 1,598
Tdark 5 | 6,588

IMPC Phenotype

preweaning lethality, incomple... 8 | 499
abnormal behavior 7 | 298
decreased total body fat amoun... 4 | 207
enlarged heart 4 | 210
enlarged spleen 4 | 41
abnormal embryo size 3 | 220
abnormal gait 3 | 69
abnormal seminal vesicle morph... 3 | 114
decreased body weight 3 | 161
decreased vertical activity 3 | 208
increased circulating choleste... 3 | 66
abnormal bone structure 2 | 187
abnormal coat appearance 2 | 31
abnormal ear morphology 2 | 9
abnormal eye morphology 2 | 68
abnormal heart morphology 2 | 162
abnormal snout morphology 2 | 23
decreased body length 2 | 101
decreased cardiac muscle contr... 2 | 11
decreased circulating glucose ... 2 | 126
decreased circulating triglyce... 2 | 79
decreased grip strength 2 | 116
decreased heart rate 2 | 18
decreased lymphocyte cell numb... 2 | 83
decreased prepulse inhibition 2 | 82
decreased startle reflex 2 | 75
embryonic growth retardation 2 | 106
embryonic lethality prior to t... 2 | 278
hydrometra 2 | 53
hyperactivity 2 | 148
hypoactivity 2 | 132
improved glucose tolerance 2 | 79
increased bone mineral content 2 | 108
increased heart weight 2 | 62
increased lean body mass 2 | 172
increased mean corpuscular vol... 2 | 92
increased or absent threshold ... 2 | 101
increased spleen weight 2 | 10
increased total body fat amoun... 2 | 134
small superior vagus ganglion 2 | 74
abnormal behavioral response t... 1 | 66
abnormal coat-hair pigmentatio... 1 | 64
abnormal craniofacial morpholo... 1 | 33
abnormal epididymis morphology 1 | 42
abnormal head morphology 1 | 10
abnormal kidney morphology 1 | 65
abnormal limb bud morphology 1 | 17
abnormal liver morphology 1 | 17
abnormal pancreas morphology 1 | 13
abnormal placenta size 1 | 20
abnormal response to new envir... 1 | 10
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal tail movements 1 | 12
abnormal urinary bladder morph... 1 | 11
absent startle reflex 1 | 24
anophthalmia 1 | 33
cardiovascular system phenotyp... 1 | 36
decreased blood urea nitrogen ... 1 | 51
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 31
decreased monocyte cell number 1 | 8
decreased threshold for audito... 1 | 26
dilated heart left ventricle 1 | 11
embryonic lethality prior to o... 1 | 239
enlarged epididymis 1 | 31
enlarged lymph nodes 1 | 37
enlarged seminal vesicle 1 | 10
female infertility 1 | 60
impaired glucose tolerance 1 | 75
increased aggression 1 | 4
increased body weight 1 | 25
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating creatini... 1 | 38
increased circulating glycerol... 1 | 9
increased circulating iron lev... 1 | 30
increased circulating thyroxin... 1 | 7
increased exploration in new e... 1 | 8
increased fasted circulating g... 1 | 76
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased monocyte cell number 1 | 63
increased vertical activity 1 | 24
limb grasping 1 | 41
male infertility 1 | 123
mammalian phenotype 1 | 17
microphthalmia 1 | 26
pale yolk sac 1 | 25
pallor 1 | 34
prolonged PQ interval 1 | 5
prolonged QT interval 1 | 38
prolonged RR interval 1 | 8
tremors 1 | 39

Disease

Carcinoma 124 | 11,493
osteosarcoma 112 | 7,950
ovarian cancer 106 | 8,520
glioblastoma 85 | 5,792
lung cancer 85 | 4,740
Cancer 82 | 2,499
psoriasis 82 | 6,694
lung carcinoma 76 | 2,843
medulloblastoma, large-cell 71 | 6,241
interstitial cystitis 64 | 2,312
atypical teratoid / rhabdoid tumor 61 | 5,112
invasive ductal carcinoma 61 | 2,951
malignant mesothelioma 57 | 3,232
ependymoma 54 | 4,679
non-small cell lung cancer 53 | 2,890
Breast cancer 52 | 3,578
adult high grade glioma 51 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 50 | 3,291
Astrocytoma, Pilocytic 49 | 3,081
ulcerative colitis 49 | 1,819
intraductal papillary-mucinous carcinoma (IPMC) 48 | 2,989
pancreatic cancer 48 | 2,398
tuberculosis 48 | 2,010
lung adenocarcinoma 45 | 2,716
group 3 medulloblastoma 42 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 42 | 2,955
cutaneous lupus erythematosus 40 | 1,057
subependymal giant cell astrocytoma 40 | 2,287
Rheumatoid arthritis 36 | 1,191
diabetes mellitus 35 | 1,728
oligodendroglioma 34 | 2,850
ductal carcinoma in situ 32 | 1,745
primary Sjogren syndrome 32 | 735
dermatomyositis 31 | 966
Kidney cancer 30 | 2,613
Multiple Sclerosis 29 | 540
astrocytic glioma 29 | 2,597
cystic fibrosis 29 | 1,696
pituitary cancer 29 | 1,972
Hypersensitivity reaction type II disease 28 | 253
Multiple myeloma 28 | 1,332
juvenile dermatomyositis 28 | 1,187
breast carcinoma 27 | 1,638
pancreatic ductal adenocarcinoma liver metastasis 27 | 1,962
primitive neuroectodermal tumor 27 | 3,035
Autosomal recessive predisposition 25 | 1,442
colon cancer 25 | 1,478
astrocytoma 24 | 1,146
group 4 medulloblastoma 24 | 1,855
primary pancreatic ductal adenocarcinoma 24 | 1,109
Schizophrenia 23 | 1,160
esophageal adenocarcinoma 23 | 737
Pick disease 22 | 1,894
Duchenne muscular dystrophy 21 | 601
Liver Cirrhosis, Experimental 21 | 769
Waldenstrons macroglobulinemia 21 | 765
Arthritis 20 | 290
Kidney disease 20 | 430
adrenocortical carcinoma 20 | 1,428
periodontitis 20 | 293
Down syndrome 19 | 499
active Crohn's disease 19 | 922
acute quadriplegic myopathy 19 | 1,158
nasopharyngeal carcinoma 19 | 1,058
Anemia 18 | 365
Human immunodeficiency virus infectious disease 18 | 138
pediatric high grade glioma 18 | 1,064
active ulcerative colitis 17 | 764
acute myeloid leukemia 17 | 783
gastric carcinoma 17 | 807
mucosa-associated lymphoid tissue lymphoma 16 | 484
Atopic dermatitis 15 | 952
Alzheimer's disease 13 | 658
Asthma 13 | 385
Atherosclerosis 13 | 291
Liver disease 13 | 237
Lymphoproliferative syndrome 13 | 58
Vascular disease 13 | 319
autosomal dominant Emery-Dreifuss muscular dystrophy 13 | 510
non-small cell lung carcinoma 13 | 317
Ankylosing spondylitis 12 | 140
Breast Neoplasms 12 | 445
Chronic Lymphocytic Leukemia 12 | 262
non primary Sjogren syndrome sicca 12 | 891
spina bifida 12 | 1,074
Endometriosis 11 | 540
Hepatitis B 11 | 108
Hypertension 11 | 396
Juvenile rheumatoid arthritis 11 | 111
Mammary Neoplasms 11 | 425
pancreatic carcinoma 11 | 562
Acquired immunodeficiency syndrome 10 | 197
Dermatitis 10 | 157
Liver cancer 10 | 604
Neurodegenerative disease 10 | 414
Splenomegaly 10 | 190
hepatocellular carcinoma 10 | 547
chronic rhinosinusitis 9 | 512
gastric cancer 9 | 459
progressive supranuclear palsy 9 | 676

Tissue

Blood and immune system 157 | 16,909
Digestive Tract 157 | 17,369
Endocrine System 157 | 18,159
Female tissues 157 | 17,400
Liver and Pancreas 157 | 16,750
Male tissues 157 | 17,142
Respiratory system 157 | 16,393
Skin and soft tissues 157 | 17,230
Urinary Tract 157 | 16,678
Cardiovascular System 155 | 15,192
Nervous System 152 | 16,725

Target Family

Non-IDG 128 | 12,091
Transporter 17 | 473
Enzyme 14 | 4,145
Kinase 6 | 634
GPCR 3 | 408
Ion Channel 3 | 344

CSPA Cell Line

U2932 171 | 171
U-251 MG 405 | 405
Glioblastoma 376 | 376
LN18 359 | 359
HEK 329 | 329
Melanoma NSph 305 | 305
U-2 OS 286 | 286
LN229 283 | 283
RD 277 | 277
T98G 276 | 276
Rh28 265 | 265
ZL55 MPM 262 | 262
HeLa 260 | 260
Adipocytes 259 | 259
B-ALL 255 | 255
MelanomaAdh 243 | 243
A431 242 | 242
U-87 MG 242 | 242
Ruch-2 240 | 240
IMR-32 231 | 231
SDM104 228 | 228
P493-6 227 | 227
SDM5 221 | 221
L428 218 | 218
PASMC 217 | 217
CD4+CD25-Tcells 213 | 213
SDM4 211 | 211
KMH2 194 | 194
HDLM-2 193 | 193
HCC4012 192 | 192
MedB1 189 | 189
Jurkat 188 | 188
NK cells 182 | 182
NB4 181 | 181
L540 179 | 179
HBL-1 171 | 171
CaLu3 167 | 167
Lymphoma 163 | 163
SU-DHL-6 160 | 160
LNT229 154 | 154
SU4 (SU-DHL-4) 154 | 154
HL-60 146 | 146
786-O 112 | 112
SDM34 86 | 86
RH4 67 | 67
Braintumor 66 | 66
hMSC 59 | 59

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Neuroplastin NPTN Tbio Non-IDG -2.31075 211.6 201
Tumor necrosis factor receptor superfamily member 11A TNFRSF11A Tbio Non-IDG -3.26478 1689.0 464
Sodium bicarbonate cotransporter 3 SLC4A7 Tbio Transporter -1.82039 64.7 133
Junctional adhesion molecule A F11R Tbio Non-IDG -2.56739 380.0 394
Large neutral amino acids transporter small subunit 1 SLC7A5 Tbio Transporter -1.90516 156.1 254
Trophoblast glycoprotein TPBG Tbio Non-IDG -2.10560 136.9 206
Zinc transporter ZIP10 SLC39A10 Tbio Transporter -1.20558 16.3 102
Activin receptor type-2A ACVR2A Tchem Kinase -2.08745 108.0 315
Zinc transporter ZIP6 SLC39A6 Tbio Transporter -1.66663 50.0 172