Development Level

Tbio 202 | 11,651
Tchem 32 | 1,388
Tdark 28 | 6,593
Tclin 24 | 612

Collection

GPCR: IDG Consortium (Complete... 2 | 25
Ion Channel: IDG Consortium (T... 2 | 99
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

abnormal behavior 13 | 298
preweaning lethality, incomple... 13 | 499
preweaning lethality, complete... 12 | 979
enlarged heart 9 | 210
decreased vertical activity 6 | 208
abnormal seminal vesicle morph... 5 | 114
decreased grip strength 5 | 116
decreased total body fat amoun... 5 | 207
abnormal bone structure 4 | 187
abnormal heart morphology 4 | 162
hyperactivity 4 | 148
increased bone mineral content 4 | 108
increased heart weight 4 | 62
increased lean body mass 4 | 172
abnormal coat appearance 3 | 31
abnormal eye morphology 3 | 68
decreased body length 3 | 101
decreased body weight 3 | 161
decreased circulating glucose ... 3 | 126
decreased circulating triglyce... 3 | 79
enlarged spleen 3 | 41
hypoactivity 3 | 132
impaired glucose tolerance 3 | 75
improved glucose tolerance 3 | 79
increased mean corpuscular vol... 3 | 92
increased total body fat amoun... 3 | 134
male infertility 3 | 123
tremors 3 | 39
abnormal bone mineralization 2 | 38
abnormal embryo size 2 | 220
abnormal kidney morphology 2 | 65
abnormal limb bud morphology 2 | 17
abnormal pericardium morpholog... 2 | 26
abnormal retina morphology 2 | 71
abnormal sleep behavior 2 | 70
cardiovascular system phenotyp... 2 | 36
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
decreased cardiac muscle contr... 2 | 11
decreased circulating creatini... 2 | 39
decreased erythrocyte cell num... 2 | 62
decreased fasted circulating g... 2 | 65
decreased heart rate 2 | 18
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular hem... 2 | 31
decreased startle reflex 2 | 75
embryonic lethality prior to t... 2 | 278
increased B cell number 2 | 9
increased circulating choleste... 2 | 66
increased circulating triglyce... 2 | 42
increased erythrocyte cell num... 2 | 39
pallor 2 | 34
abnormal behavioral response t... 1 | 66
abnormal ear morphology 1 | 9
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal gait 1 | 69
abnormal liver morphology 1 | 17
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal response to new envir... 1 | 10
abnormal retinal blood vessel ... 1 | 26
abnormal tail movements 1 | 12
abnormal vibrissa morphology 1 | 25
abnormal vitelline vasculature... 1 | 6
abnormal vocalization 1 | 21
absent vibrissae 1 | 12
decreased T cell number 1 | 15
decreased circulating bilirubi... 1 | 19
decreased circulating calcium ... 1 | 36
decreased circulating phosphat... 1 | 27
decreased eosinophil cell numb... 1 | 24
decreased exploration in new e... 1 | 11
decreased mean platelet volume 1 | 25
decreased total retina thickne... 1 | 17
dilated heart left ventricle 1 | 11
enlarged epididymis 1 | 31
enlarged lymph nodes 1 | 37
increased aggression 1 | 4
increased body length 1 | 32
increased body weight 1 | 25
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased circulating glycerol... 1 | 9
increased circulating iron lev... 1 | 30
increased exploration in new e... 1 | 8
increased heart rate 1 | 23
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased mean platelet volume 1 | 45
increased startle reflex 1 | 112
increased vertical activity 1 | 24
persistence of hyaloid vascula... 1 | 33
polycystic kidney 1 | 15
premature death 1 | 5
trunk curl 1 | 16
vertebral fusion 1 | 23

Disease

Carcinoma 221 | 11,493
ovarian cancer 194 | 8,520
glioblastoma 170 | 5,792
osteosarcoma 155 | 7,950
medulloblastoma, large-cell 135 | 6,241
psoriasis 135 | 6,694
ependymoma 132 | 4,679
atypical teratoid / rhabdoid tumor 124 | 5,112
Breast cancer 109 | 3,578
malignant mesothelioma 108 | 3,232
Astrocytoma, Pilocytic 105 | 3,081
lung cancer 100 | 4,740
Cancer 97 | 2,499
adult high grade glioma 96 | 3,801
group 3 medulloblastoma 95 | 4,104
invasive ductal carcinoma 94 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 93 | 2,955
pancreatic cancer 92 | 2,398
lung carcinoma 90 | 2,843
non-small cell lung cancer 82 | 2,890
intraductal papillary-mucinous neoplasm (IPMN) 81 | 3,291
lung adenocarcinoma 79 | 2,716
oligodendroglioma 79 | 2,850
intraductal papillary-mucinous carcinoma (IPMC) 78 | 2,989
Kidney cancer 74 | 2,613
ulcerative colitis 74 | 1,819
primitive neuroectodermal tumor 72 | 3,035
subependymal giant cell astrocytoma 68 | 2,287
cystic fibrosis 67 | 1,696
astrocytic glioma 66 | 2,597
primary pancreatic ductal adenocarcinoma 64 | 1,109
interstitial cystitis 62 | 2,312
pituitary cancer 56 | 1,972
diabetes mellitus 54 | 1,728
pancreatic ductal adenocarcinoma liver metastasis 54 | 1,962
tuberculosis 54 | 2,010
breast carcinoma 53 | 1,638
juvenile dermatomyositis 52 | 1,187
ductal carcinoma in situ 51 | 1,745
gastric carcinoma 51 | 807
group 4 medulloblastoma 47 | 1,855
Autosomal recessive predisposition 46 | 1,442
Duchenne muscular dystrophy 45 | 601
Pick disease 43 | 1,894
dermatomyositis 40 | 966
pediatric high grade glioma 40 | 1,064
adrenocortical carcinoma 39 | 1,428
colon cancer 39 | 1,478
acute quadriplegic myopathy 37 | 1,158
autosomal dominant Emery-Dreifuss muscular dystrophy 37 | 510
astrocytoma 36 | 1,146
Liver Cirrhosis, Experimental 35 | 769
Schizophrenia 34 | 1,160
Rheumatoid arthritis 30 | 1,191
esophageal adenocarcinoma 29 | 737
Alzheimer's disease 28 | 658
Multiple Sclerosis 28 | 540
nasopharyngeal carcinoma 28 | 1,058
Multiple myeloma 27 | 1,332
Atopic dermatitis 26 | 952
cutaneous lupus erythematosus 24 | 1,057
Liver cancer 23 | 604
Melanoma 23 | 711
fibroadenoma 23 | 559
Down syndrome 22 | 499
Kidney disease 22 | 430
active Crohn's disease 22 | 922
active ulcerative colitis 22 | 764
Vascular disease 21 | 319
mucosa-associated lymphoid tissue lymphoma 21 | 484
interstitial lung disease 20 | 298
primary Sjogren syndrome 20 | 735
Hypersensitivity reaction type II disease 19 | 253
Becker muscular dystrophy 18 | 191
aldosterone-producing adenoma 18 | 665
medulloblastoma 18 | 720
Acquired scoliosis 17 | 281
Atherosclerosis 17 | 291
Breast Neoplasms 17 | 445
Curvature of spine 17 | 282
Intellectual disability 17 | 1,016
Liver Cirrhosis 17 | 181
Prostatic Neoplasms 17 | 495
spina bifida 17 | 1,074
Endometriosis 16 | 540
Mammary Neoplasms 16 | 425
Muscle hypotonia 16 | 571
Neoplasm Invasiveness 16 | 161
Obesity 16 | 678
Short stature 16 | 531
limb girdle muscular dystrophy 2A 16 | 213
progressive supranuclear palsy 16 | 676
Arthritis 15 | 290
Asthma 15 | 385
Coronary artery disease 15 | 268
Skin cancer 15 | 469
sonic hedgehog group medulloblastoma 15 | 467
urothelial carcinoma 15 | 318
Low intelligence 14 | 645
Mental Retardation 14 | 645

Tissue

Endocrine System 279 | 18,159
Urinary Tract 279 | 16,678
Digestive Tract 278 | 17,369
Female tissues 278 | 17,400
Liver and Pancreas 278 | 16,750
Male tissues 278 | 17,142
Skin and soft tissues 278 | 17,230
Blood and immune system 277 | 16,909
Respiratory system 277 | 16,393
Nervous System 276 | 16,725
Cardiovascular System 274 | 15,192

Target Family

Non-IDG 206 | 12,091
Enzyme 37 | 4,145
GPCR 14 | 408
Transporter 14 | 473
Kinase 9 | 634
Ion Channel 5 | 344
Transcription Factor 1 | 1,400

CSPA Cell Line

U-2 OS 286 | 286
U-251 MG 405 | 405
Glioblastoma 376 | 376
LN18 359 | 359
HEK 329 | 329
Melanoma NSph 305 | 305
LN229 283 | 283
RD 277 | 277
T98G 276 | 276
Rh28 265 | 265
ZL55 MPM 262 | 262
HeLa 260 | 260
Adipocytes 259 | 259
B-ALL 255 | 255
MelanomaAdh 243 | 243
A431 242 | 242
U-87 MG 242 | 242
Ruch-2 240 | 240
IMR-32 231 | 231
SDM104 228 | 228
P493-6 227 | 227
SDM5 221 | 221
L428 218 | 218
PASMC 217 | 217
CD4+CD25-Tcells 213 | 213
SDM4 211 | 211
KMH2 194 | 194
HDLM-2 193 | 193
HCC4012 192 | 192
MedB1 189 | 189
Jurkat 188 | 188
NK cells 182 | 182
NB4 181 | 181
L540 179 | 179
HBL-1 171 | 171
U2932 171 | 171
CaLu3 167 | 167
Lymphoma 163 | 163
SU-DHL-6 160 | 160
LNT229 154 | 154
SU4 (SU-DHL-4) 154 | 154
HL-60 146 | 146
786-O 112 | 112
SDM34 86 | 86
RH4 67 | 67
Braintumor 66 | 66
hMSC 59 | 59

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Integrin alpha-2 ITGA2 Tbio Non-IDG -2.58423 335.9 895
Protein disulfide-isomerase TMX3 TMX3 Tbio Enzyme -0.72922 5.29 80
HLA class I histocompatibility antigen, A-25 alpha chain HLA-A Tbio Non-IDG -2.41667 4123.8 0
Protein phosphatase 1 regulatory subunit 29 ELFN2 Tdark Enzyme 0.06 0.68 51
Protein tweety homolog 3 TTYH3 Tbio Ion Channel -0.17609 1.56 17
Interleukin-6 receptor subunit beta IL6ST Tclin Non-IDG -1.72489 55.4 555
Integrin alpha-3 ITGA3 Tbio Non-IDG -2.08360 104.1 587
Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 Tclin Ion Channel -1.59683 37.4 101
Interferon gamma receptor 1 IFNGR1 Tbio Non-IDG -2.23009 172.7 518