Development Level

Tbio 153 | 11,445
Tchem 32 | 1,598
Tclin 28 | 613
Tdark 15 | 6,588

Collection

GPCR: IDG Consortium (Complete... 2 | 25
GPCR: IDG Consortium (Targets) 2 | 126

IMPC Phenotype

abnormal behavior 8 | 298
preweaning lethality, incomple... 8 | 499
preweaning lethality, complete... 7 | 979
abnormal embryo size 5 | 220
decreased total body fat amoun... 5 | 207
embryonic lethality prior to t... 5 | 278
increased heart weight 5 | 62
abnormal eye morphology 4 | 68
abnormal seminal vesicle morph... 4 | 114
decreased grip strength 4 | 116
decreased vertical activity 4 | 208
increased bone mineral content 4 | 108
increased lean body mass 4 | 172
abnormal heart morphology 3 | 162
abnormal limb bud morphology 3 | 17
decreased body weight 3 | 161
decreased bone mineral content 3 | 151
embryonic growth retardation 3 | 106
enlarged heart 3 | 210
increased mean corpuscular vol... 3 | 92
tremors 3 | 39
abnormal bone structure 2 | 187
abnormal cranium morphology 2 | 36
abnormal femur morphology 2 | 14
abnormal pericardium morpholog... 2 | 26
decreased body length 2 | 101
decreased circulating bilirubi... 2 | 19
decreased circulating choleste... 2 | 93
decreased circulating glucose ... 2 | 126
decreased circulating total pr... 2 | 49
decreased circulating triglyce... 2 | 79
dilated heart left ventricle 2 | 11
hyperactivity 2 | 148
improved glucose tolerance 2 | 79
increased bone mineral density 2 | 72
increased circulating triglyce... 2 | 42
increased erythrocyte cell num... 2 | 39
increased hemoglobin content 2 | 45
increased leukocyte cell numbe... 2 | 47
increased mean corpuscular hem... 2 | 96
increased total body fat amoun... 2 | 134
pallor 2 | 34
prolonged ST segment 2 | 36
abnormal behavioral response t... 1 | 66
abnormal coat appearance 1 | 31
abnormal coat-hair pigmentatio... 1 | 64
abnormal craniofacial morpholo... 1 | 33
abnormal ear morphology 1 | 9
abnormal epididymis morphology 1 | 42
abnormal facial morphology 1 | 17
abnormal gait 1 | 69
abnormal head shape 1 | 10
abnormal liver morphology 1 | 17
abnormal neural tube closure 1 | 46
abnormal placenta size 1 | 20
abnormal response to new envir... 1 | 10
abnormal sleep behavior 1 | 70
abnormal snout morphology 1 | 23
abnormal tooth morphology 1 | 24
abnormal urinary bladder morph... 1 | 11
abnormal vocalization 1 | 21
absent startle reflex 1 | 24
absent vibrissae 1 | 12
cardiovascular system phenotyp... 1 | 36
decreased bone mineral density 1 | 126
decreased cardiac muscle contr... 1 | 11
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating calcium ... 1 | 36
decreased circulating free fat... 1 | 31
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased exploration in new e... 1 | 11
decreased heart rate variabili... 1 | 13
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased threshold for audito... 1 | 26
embryonic lethality prior to o... 1 | 239
enlarged epididymis 1 | 31
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased blood urea nitrogen ... 1 | 48
increased body weight 1 | 25
increased circulating choleste... 1 | 66
increased circulating iron lev... 1 | 30
increased exploration in new e... 1 | 8
increased fasted circulating g... 1 | 76
increased hematocrit 1 | 46
increased red blood cell distr... 1 | 34
increased vertical activity 1 | 24
pale yolk sac 1 | 25
polycystic kidney 1 | 15
syndactyly 1 | 23
trunk curl 1 | 16

Disease

Carcinoma 187 | 11,493
ovarian cancer 154 | 8,520
glioblastoma 129 | 5,792
osteosarcoma 122 | 7,950
ependymoma 106 | 4,679
lung carcinoma 105 | 2,843
atypical teratoid / rhabdoid tumor 104 | 5,112
Cancer 102 | 2,499
psoriasis 101 | 6,694
medulloblastoma, large-cell 99 | 6,241
malignant mesothelioma 96 | 3,232
Breast cancer 93 | 3,578
lung cancer 93 | 4,740
invasive ductal carcinoma 90 | 2,951
pancreatic cancer 89 | 2,398
Astrocytoma, Pilocytic 87 | 3,081
adult high grade glioma 81 | 3,801
intraductal papillary-mucinous adenoma (IPMA) 80 | 2,955
lung adenocarcinoma 77 | 2,716
non-small cell lung cancer 77 | 2,890
interstitial cystitis 76 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 67 | 2,989
cystic fibrosis 66 | 1,696
ulcerative colitis 66 | 1,819
oligodendroglioma 65 | 2,850
intraductal papillary-mucinous neoplasm (IPMN) 62 | 3,291
primitive neuroectodermal tumor 61 | 3,035
ductal carcinoma in situ 60 | 1,745
group 3 medulloblastoma 60 | 4,104
Kidney cancer 58 | 2,613
primary pancreatic ductal adenocarcinoma 58 | 1,109
subependymal giant cell astrocytoma 52 | 2,287
gastric carcinoma 51 | 807
tuberculosis 50 | 2,010
breast carcinoma 48 | 1,638
diabetes mellitus 48 | 1,728
astrocytic glioma 46 | 2,597
pituitary cancer 45 | 1,972
juvenile dermatomyositis 44 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 42 | 1,962
colon cancer 40 | 1,478
adrenocortical carcinoma 37 | 1,428
Duchenne muscular dystrophy 36 | 601
Pick disease 35 | 1,894
group 4 medulloblastoma 34 | 1,855
pediatric high grade glioma 31 | 1,064
Autosomal recessive predisposition 30 | 1,442
astrocytoma 30 | 1,146
dermatomyositis 30 | 966
nasopharyngeal carcinoma 30 | 1,058
acute quadriplegic myopathy 29 | 1,158
Atopic dermatitis 28 | 952
Liver Cirrhosis, Experimental 28 | 769
autosomal dominant Emery-Dreifuss muscular dystrophy 27 | 510
esophageal adenocarcinoma 27 | 737
Kidney disease 26 | 430
Rheumatoid arthritis 25 | 1,191
Schizophrenia 25 | 1,160
cutaneous lupus erythematosus 25 | 1,057
Alzheimer's disease 24 | 658
Anemia 24 | 365
Multiple Sclerosis 23 | 540
Breast Neoplasms 22 | 445
Endometriosis 21 | 540
Hypertension 21 | 396
Mammary Neoplasms 21 | 425
Multiple myeloma 21 | 1,332
active ulcerative colitis 21 | 764
Hypersensitivity reaction type II disease 20 | 253
active Crohn's disease 20 | 922
fibroadenoma 20 | 559
Arthritis 19 | 290
Coronary artery disease 19 | 268
Obesity 19 | 678
Prostatic Neoplasms 19 | 495
Liver disease 18 | 237
Atherosclerosis 17 | 291
Melanoma 17 | 711
Vascular disease 17 | 319
Becker muscular dystrophy 16 | 191
Down syndrome 16 | 499
Stomach Neoplasms 16 | 300
acute myeloid leukemia 16 | 783
aldosterone-producing adenoma 16 | 665
interstitial lung disease 16 | 298
mucosa-associated lymphoid tissue lymphoma 16 | 484
primary Sjogren syndrome 16 | 735
spina bifida 16 | 1,074
head and neck cancer 15 | 271
medulloblastoma 15 | 720
Asthma 14 | 385
Hypertensive disease 14 | 292
Liver cancer 14 | 604
Liver carcinoma 14 | 240
Lung Neoplasms 14 | 232
Neoplasm Invasiveness 14 | 161
Neoplasm Metastasis 14 | 168
non primary Sjogren syndrome sicca 14 | 891
pancreatic carcinoma 14 | 562
posterior fossa group A ependymoma 14 | 468

Tissue

Endocrine System 221 | 18,159
Digestive Tract 220 | 17,369
Female tissues 220 | 17,400
Liver and Pancreas 220 | 16,750
Male tissues 220 | 17,142
Respiratory system 220 | 16,393
Skin and soft tissues 220 | 17,230
Urinary Tract 220 | 16,678
Blood and immune system 218 | 16,909
Nervous System 218 | 16,725
Cardiovascular System 213 | 15,192

Target Family

Non-IDG 160 | 12,091
Enzyme 32 | 4,145
Transporter 13 | 473
GPCR 10 | 408
Kinase 10 | 634
Ion Channel 3 | 344

CSPA Cell Line

SDM104 228 | 228
U-251 MG 405 | 405
Glioblastoma 376 | 376
LN18 359 | 359
HEK 329 | 329
Melanoma NSph 305 | 305
U-2 OS 286 | 286
LN229 283 | 283
RD 277 | 277
T98G 276 | 276
Rh28 265 | 265
ZL55 MPM 262 | 262
HeLa 260 | 260
Adipocytes 259 | 259
B-ALL 255 | 255
MelanomaAdh 243 | 243
A431 242 | 242
U-87 MG 242 | 242
Ruch-2 240 | 240
IMR-32 231 | 231
P493-6 227 | 227
SDM5 221 | 221
L428 218 | 218
PASMC 217 | 217
CD4+CD25-Tcells 213 | 213
SDM4 211 | 211
KMH2 194 | 194
HDLM-2 193 | 193
HCC4012 192 | 192
MedB1 189 | 189
Jurkat 188 | 188
NK cells 182 | 182
NB4 181 | 181
L540 179 | 179
HBL-1 171 | 171
U2932 171 | 171
CaLu3 167 | 167
Lymphoma 163 | 163
SU-DHL-6 160 | 160
LNT229 154 | 154
SU4 (SU-DHL-4) 154 | 154
HL-60 146 | 146
786-O 112 | 112
SDM34 86 | 86
RH4 67 | 67
Braintumor 66 | 66
hMSC 59 | 59

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Neuroplastin NPTN Tbio Non-IDG -2.31075 211.6 201
Growth/differentiation factor 15 GDF15 Tbio Non-IDG -2.84344 761.3 702
CD109 antigen CD109 Tbio Non-IDG -1.85817 77.8 239
Protein HEG homolog 1 HEG1 Tbio Non-IDG -2.11308 129.3 11
Sodium bicarbonate cotransporter 3 SLC4A7 Tbio Transporter -1.82039 64.7 133
Endoglin ENG Tbio Non-IDG -3.10482 1235.9 1622
G-protein coupled receptor 39 GPR39 Tchem GPCR -1.77076 66.5 232
VPS10 domain-containing receptor SorCS2 SORCS2 Tbio Non-IDG -0.79588 6.26 56
Trophoblast glycoprotein TPBG Tbio Non-IDG -2.10560 136.9 206