Development Level

Tbio 120 | 11,445
Tchem 31 | 1,598
Tclin 20 | 613
Tdark 10 | 6,588

Collection

GPCR: IDG Consortium (Targets) 3 | 126
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 7 | 979
abnormal behavior 6 | 298
decreased total body fat amoun... 5 | 207
decreased vertical activity 4 | 208
enlarged heart 4 | 210
increased heart weight 4 | 62
decreased body weight 3 | 161
embryonic lethality prior to t... 3 | 278
enlarged spleen 3 | 41
increased bone mineral content 3 | 108
increased circulating choleste... 3 | 66
increased mean corpuscular vol... 3 | 92
preweaning lethality, incomple... 3 | 499
abnormal bone structure 2 | 187
abnormal embryo size 2 | 220
abnormal eye morphology 2 | 68
abnormal femur morphology 2 | 14
abnormal gait 2 | 69
abnormal heart morphology 2 | 162
abnormal seminal vesicle morph... 2 | 114
abnormal snout morphology 2 | 23
decreased body length 2 | 101
decreased cardiac muscle contr... 2 | 11
decreased erythrocyte cell num... 2 | 62
decreased prepulse inhibition 2 | 82
dilated heart left ventricle 2 | 11
embryonic growth retardation 2 | 106
embryonic lethality prior to o... 2 | 239
improved glucose tolerance 2 | 79
increased lean body mass 2 | 172
pale yolk sac 2 | 25
abnormal bone mineralization 1 | 38
abnormal brain morphology 1 | 13
abnormal coat appearance 1 | 31
abnormal ear morphology 1 | 9
abnormal epididymis morphology 1 | 42
abnormal head morphology 1 | 10
abnormal humerus morphology 1 | 11
abnormal limb bud morphology 1 | 17
abnormal liver morphology 1 | 17
abnormal locomotor activation 1 | 16
abnormal pancreas morphology 1 | 13
abnormal placenta size 1 | 20
abnormal response to new envir... 1 | 10
abnormal social-conspecific in... 1 | 3
abnormal startle reflex 1 | 15
abnormal urinary bladder morph... 1 | 11
abnormal urination 1 | 1
abnormal vertebrae morphology 1 | 18
abnormal vibrissa morphology 1 | 25
absent startle reflex 1 | 24
cardiovascular system phenotyp... 1 | 36
decreased CD4-positive, alpha ... 1 | 7
decreased CD8-positive, alpha-... 1 | 8
decreased T cell number 1 | 15
decreased bone mineral density 1 | 126
decreased circulating bilirubi... 1 | 19
decreased circulating creatini... 1 | 39
decreased circulating glucose ... 1 | 126
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased heart rate 1 | 18
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 31
decreased mean platelet volume 1 | 25
decreased startle reflex 1 | 75
decreased threshold for audito... 1 | 26
edema 1 | 59
enlarged epididymis 1 | 31
enlarged lymph nodes 1 | 37
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased B cell number 1 | 9
increased aggression 1 | 4
increased body length 1 | 32
increased body weight 1 | 25
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating creatini... 1 | 38
increased circulating iron lev... 1 | 30
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 39
increased exploration in new e... 1 | 8
increased fasted circulating g... 1 | 76
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 96
increased mean corpuscular hem... 1 | 36
increased mean platelet volume 1 | 45
increased or absent threshold ... 1 | 101
increased spleen weight 1 | 10
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
mammalian phenotype 1 | 17
pallor 1 | 34
prolonged PQ interval 1 | 5
prolonged QT interval 1 | 38
tremors 1 | 39
vertebral fusion 1 | 23

Disease

Carcinoma 135 | 11,493
ovarian cancer 111 | 8,520
osteosarcoma 108 | 7,950
glioblastoma 98 | 5,792
psoriasis 87 | 6,694
Cancer 82 | 2,499
medulloblastoma, large-cell 78 | 6,241
lung cancer 74 | 4,740
lung carcinoma 72 | 2,843
atypical teratoid / rhabdoid tumor 67 | 5,112
ependymoma 66 | 4,679
malignant mesothelioma 60 | 3,232
Astrocytoma, Pilocytic 58 | 3,081
invasive ductal carcinoma 58 | 2,951
adult high grade glioma 56 | 3,801
interstitial cystitis 54 | 2,312
Breast cancer 53 | 3,578
non-small cell lung cancer 53 | 2,890
intraductal papillary-mucinous neoplasm (IPMN) 51 | 3,291
pancreatic cancer 51 | 2,398
group 3 medulloblastoma 50 | 4,104
tuberculosis 49 | 2,010
subependymal giant cell astrocytoma 48 | 2,287
intraductal papillary-mucinous adenoma (IPMA) 47 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 47 | 2,989
lung adenocarcinoma 45 | 2,716
ulcerative colitis 43 | 1,819
diabetes mellitus 39 | 1,728
primitive neuroectodermal tumor 38 | 3,035
oligodendroglioma 36 | 2,850
Kidney cancer 35 | 2,613
astrocytic glioma 33 | 2,597
ductal carcinoma in situ 33 | 1,745
juvenile dermatomyositis 33 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 33 | 1,962
cystic fibrosis 32 | 1,696
astrocytoma 30 | 1,146
Liver Cirrhosis, Experimental 29 | 769
dermatomyositis 29 | 966
primary pancreatic ductal adenocarcinoma 29 | 1,109
cutaneous lupus erythematosus 27 | 1,057
pituitary cancer 27 | 1,972
Multiple Sclerosis 26 | 540
Rheumatoid arthritis 26 | 1,191
breast carcinoma 26 | 1,638
gastric carcinoma 26 | 807
Multiple myeloma 25 | 1,332
group 4 medulloblastoma 24 | 1,855
Hypersensitivity reaction type II disease 23 | 253
Duchenne muscular dystrophy 22 | 601
colon cancer 22 | 1,478
Alzheimer's disease 21 | 658
esophageal adenocarcinoma 21 | 737
Kidney disease 20 | 430
acute quadriplegic myopathy 20 | 1,158
pediatric high grade glioma 20 | 1,064
primary Sjogren syndrome 20 | 735
Schizophrenia 19 | 1,160
active Crohn's disease 19 | 922
mucosa-associated lymphoid tissue lymphoma 19 | 484
Pick disease 18 | 1,894
adrenocortical carcinoma 18 | 1,428
Anemia 17 | 365
nasopharyngeal carcinoma 17 | 1,058
Arthritis 16 | 290
Autosomal recessive predisposition 16 | 1,442
Liver disease 16 | 237
autosomal dominant Emery-Dreifuss muscular dystrophy 16 | 510
Breast Neoplasms 15 | 445
Mammary Neoplasms 15 | 425
Waldenstrons macroglobulinemia 15 | 765
Asthma 14 | 385
Down syndrome 14 | 499
Vascular disease 14 | 319
active ulcerative colitis 14 | 764
acute myeloid leukemia 14 | 783
Hypertension 13 | 396
Neoplasm Invasiveness 13 | 161
Atopic dermatitis 12 | 952
Bipolar Disorder 12 | 666
Human immunodeficiency virus infectious disease 12 | 138
Neurodegenerative disease 12 | 414
nephrosclerosis 12 | 333
Atherosclerosis 11 | 291
Prostatic Neoplasms 11 | 495
non primary Sjogren syndrome sicca 11 | 891
pancreatic carcinoma 11 | 562
spina bifida 11 | 1,074
Cerebrovascular disease 10 | 238
Endometriosis 10 | 540
Hypertensive disease 10 | 292
Intellectual disability 10 | 1,016
Liver Cirrhosis 10 | 181
aldosterone-producing adenoma 10 | 665
head and neck cancer and chronic obstructive pulmonary disease 10 | 239
periodontitis 10 | 293
Low intelligence 9 | 645
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Poor school performance 9 | 645

Tissue

Blood and immune system 174 | 16,909
Respiratory system 174 | 16,393
Urinary Tract 174 | 16,678
Digestive Tract 173 | 17,369
Endocrine System 173 | 18,159
Female tissues 173 | 17,400
Skin and soft tissues 173 | 17,230
Liver and Pancreas 172 | 16,750
Male tissues 172 | 17,142
Nervous System 172 | 16,725
Cardiovascular System 170 | 15,192

Target Family

Non-IDG 121 | 12,091
Enzyme 19 | 4,145
Transporter 14 | 473
GPCR 11 | 408
Kinase 10 | 634
Ion Channel 5 | 344
Transcription Factor 1 | 1,400

CSPA Cell Line

NB4 181 | 181
U-251 MG 405 | 405
Glioblastoma 376 | 376
LN18 359 | 359
HEK 329 | 329
Melanoma NSph 305 | 305
U-2 OS 286 | 286
LN229 283 | 283
RD 277 | 277
T98G 276 | 276
Rh28 265 | 265
ZL55 MPM 262 | 262
HeLa 260 | 260
Adipocytes 259 | 259
B-ALL 255 | 255
MelanomaAdh 243 | 243
A431 242 | 242
U-87 MG 242 | 242
Ruch-2 240 | 240
IMR-32 231 | 231
SDM104 228 | 228
P493-6 227 | 227
SDM5 221 | 221
L428 218 | 218
PASMC 217 | 217
CD4+CD25-Tcells 213 | 213
SDM4 211 | 211
KMH2 194 | 194
HDLM-2 193 | 193
HCC4012 192 | 192
MedB1 189 | 189
Jurkat 188 | 188
NK cells 182 | 182
L540 179 | 179
HBL-1 171 | 171
U2932 171 | 171
CaLu3 167 | 167
Lymphoma 163 | 163
SU-DHL-6 160 | 160
LNT229 154 | 154
SU4 (SU-DHL-4) 154 | 154
HL-60 146 | 146
786-O 112 | 112
SDM34 86 | 86
RH4 67 | 67
Braintumor 66 | 66
hMSC 59 | 59

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Neuroplastin NPTN Tbio Non-IDG -2.31075 211.6 201
Leukocyte-associated immunoglobulin-like receptor 1 LAIR1 Tbio Non-IDG -1.74760 64.2 487
Sodium bicarbonate cotransporter 3 SLC4A7 Tbio Transporter -1.82039 64.7 133
Stabilin-1 STAB1 Tbio Non-IDG -1.61013 45.4 107
Prostaglandin D2 receptor 2 PTGDR2 Tchem GPCR -2.38441 265.9 439
Zinc transporter ZIP10 SLC39A10 Tbio Transporter -1.20558 16.3 102
CD276 antigen CD276 Tbio Non-IDG -3.03140 785.5 481
Zinc transporter ZIP6 SLC39A6 Tbio Transporter -1.66663 50.0 172
Disintegrin and metalloproteinase domain-containing protein 15 ADAM15 Tbio Enzyme -1.87408 84.1 301