Development Level

Tbio 172 | 11,651
Tchem 36 | 1,388
Tdark 20 | 6,593
Tclin 15 | 612

Collection

GPCR: IDG Consortium (Complete... 2 | 25
RFA-RM-18-021 2 | 328
GPCR: IDG Consortium (Targets) 1 | 126
Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

preweaning lethality, incomple... 11 | 499
preweaning lethality, complete... 8 | 979
increased lean body mass 6 | 172
abnormal behavior 5 | 298
decreased total body fat amoun... 5 | 207
increased bone mineral content 5 | 108
decreased startle reflex 4 | 75
decreased vertical activity 4 | 208
increased total body fat amoun... 4 | 134
abnormal coat appearance 3 | 31
abnormal embryo size 3 | 220
abnormal eye morphology 3 | 68
abnormal skin morphology 3 | 50
abnormal sleep behavior 3 | 70
decreased circulating glucose ... 3 | 126
decreased grip strength 3 | 116
embryonic lethality prior to t... 3 | 278
enlarged heart 3 | 210
hypoactivity 3 | 132
increased circulating choleste... 3 | 66
tremors 3 | 39
abnormal bone structure 2 | 187
abnormal coat-hair pigmentatio... 2 | 64
abnormal gait 2 | 69
abnormal limb bud morphology 2 | 17
abnormal seminal vesicle morph... 2 | 114
cardiovascular system phenotyp... 2 | 36
decreased body length 2 | 101
decreased body weight 2 | 161
decreased circulating triglyce... 2 | 79
decreased erythrocyte cell num... 2 | 62
decreased fasted circulating g... 2 | 65
decreased prepulse inhibition 2 | 82
enlarged spleen 2 | 41
hyperactivity 2 | 148
increased body weight 2 | 25
increased heart weight 2 | 62
increased mean corpuscular vol... 2 | 92
increased startle reflex 2 | 112
male infertility 2 | 123
pallor 2 | 34
abnormal behavioral response t... 1 | 66
abnormal ear morphology 1 | 9
abnormal epididymis morphology 1 | 42
abnormal femur morphology 1 | 14
abnormal head morphology 1 | 10
abnormal lung morphology 1 | 26
abnormal pericardium morpholog... 1 | 26
abnormal placenta size 1 | 20
abnormal retina morphology 1 | 71
abnormal snout morphology 1 | 23
abnormal startle reflex 1 | 15
abnormal tail movements 1 | 12
abnormal urinary bladder morph... 1 | 11
abnormal vibrissa morphology 1 | 25
absent startle reflex 1 | 24
absent vibrissae 1 | 12
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased cardiac muscle contr... 1 | 11
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating phosphat... 1 | 27
decreased eosinophil cell numb... 1 | 24
decreased exploration in new e... 1 | 11
decreased heart rate 1 | 18
decreased heart rate variabili... 1 | 13
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 31
decreased mean platelet volume 1 | 25
edema 1 | 59
embryonic growth retardation 1 | 106
enlarged epididymis 1 | 31
enlarged lymph nodes 1 | 37
hemorrhage 1 | 23
impaired glucose tolerance 1 | 75
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating creatini... 1 | 38
increased circulating glycerol... 1 | 9
increased circulating iron lev... 1 | 30
increased circulating triglyce... 1 | 42
increased exploration in new e... 1 | 8
increased fasted circulating g... 1 | 76
increased heart rate 1 | 23
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased mean platelet volume 1 | 45
long tibia 1 | 25
pale yolk sac 1 | 25
persistence of hyaloid vascula... 1 | 33
premature death 1 | 5
prenatal lethality prior to he... 1 | 87
prolonged PQ interval 1 | 5
unresponsive to tactile stimul... 1 | 8
vertebral fusion 1 | 23

Disease

Carcinoma 188 | 11,493
ovarian cancer 160 | 8,520
osteosarcoma 137 | 7,950
glioblastoma 134 | 5,792
medulloblastoma, large-cell 109 | 6,241
psoriasis 108 | 6,694
atypical teratoid / rhabdoid tumor 99 | 5,112
lung cancer 98 | 4,740
ependymoma 97 | 4,679
Astrocytoma, Pilocytic 92 | 3,081
Breast cancer 88 | 3,578
Cancer 87 | 2,499
invasive ductal carcinoma 83 | 2,951
malignant mesothelioma 80 | 3,232
lung carcinoma 74 | 2,843
non-small cell lung cancer 74 | 2,890
intraductal papillary-mucinous neoplasm (IPMN) 73 | 3,291
pancreatic cancer 73 | 2,398
intraductal papillary-mucinous adenoma (IPMA) 72 | 2,955
adult high grade glioma 71 | 3,801
oligodendroglioma 68 | 2,850
group 3 medulloblastoma 67 | 4,104
interstitial cystitis 66 | 2,312
lung adenocarcinoma 66 | 2,716
intraductal papillary-mucinous carcinoma (IPMC) 64 | 2,989
Kidney cancer 59 | 2,613
ulcerative colitis 59 | 1,819
subependymal giant cell astrocytoma 58 | 2,287
cystic fibrosis 53 | 1,696
astrocytic glioma 52 | 2,597
diabetes mellitus 50 | 1,728
ductal carcinoma in situ 50 | 1,745
primitive neuroectodermal tumor 50 | 3,035
pancreatic ductal adenocarcinoma liver metastasis 48 | 1,962
juvenile dermatomyositis 46 | 1,187
primary pancreatic ductal adenocarcinoma 46 | 1,109
tuberculosis 46 | 2,010
breast carcinoma 42 | 1,638
colon cancer 42 | 1,478
gastric carcinoma 41 | 807
Pick disease 40 | 1,894
Duchenne muscular dystrophy 38 | 601
pituitary cancer 38 | 1,972
Autosomal recessive predisposition 36 | 1,442
adrenocortical carcinoma 36 | 1,428
group 4 medulloblastoma 36 | 1,855
dermatomyositis 35 | 966
Rheumatoid arthritis 32 | 1,191
acute quadriplegic myopathy 32 | 1,158
esophageal adenocarcinoma 29 | 737
pediatric high grade glioma 29 | 1,064
active Crohn's disease 28 | 922
astrocytoma 28 | 1,146
Multiple Sclerosis 27 | 540
Multiple myeloma 27 | 1,332
Alzheimer's disease 26 | 658
Schizophrenia 26 | 1,160
Down syndrome 25 | 499
cutaneous lupus erythematosus 25 | 1,057
autosomal dominant Emery-Dreifuss muscular dystrophy 24 | 510
nasopharyngeal carcinoma 24 | 1,058
active ulcerative colitis 21 | 764
Breast Neoplasms 20 | 445
Endometriosis 20 | 540
Mammary Neoplasms 20 | 425
Liver Cirrhosis, Experimental 19 | 769
Intellectual disability 18 | 1,016
Waldenstrons macroglobulinemia 18 | 765
fibroadenoma 18 | 559
primary Sjogren syndrome 18 | 735
progressive supranuclear palsy 18 | 676
Hypersensitivity reaction type II disease 17 | 253
Melanoma 17 | 711
Vascular disease 17 | 319
aldosterone-producing adenoma 17 | 665
Atopic dermatitis 16 | 952
mucosa-associated lymphoid tissue lymphoma 16 | 484
sonic hedgehog group medulloblastoma 16 | 467
Kidney disease 15 | 430
acute myeloid leukemia 15 | 783
spina bifida 15 | 1,074
Arthritis 14 | 290
Becker muscular dystrophy 14 | 191
Dull intelligence 14 | 645
Liver cancer 14 | 604
Low intelligence 14 | 645
Mental Retardation 14 | 645
Mental deficiency 14 | 645
Poor school performance 14 | 645
medulloblastoma 14 | 720
non primary Sjogren syndrome sicca 14 | 891
posterior fossa group A ependymoma 14 | 468
Anemia 13 | 365
Atherosclerosis 13 | 291
Autistic Disorder 13 | 364
Muscle hypotonia 13 | 571
Neoplasm Invasiveness 13 | 161
Asthma 12 | 385
Bipolar Disorder 12 | 666
Prostatic Neoplasms 12 | 495

Tissue

Endocrine System 232 | 18,159
Female tissues 232 | 17,400
Skin and soft tissues 232 | 17,230
Blood and immune system 231 | 16,909
Male tissues 231 | 17,142
Nervous System 231 | 16,725
Respiratory system 231 | 16,393
Digestive Tract 230 | 17,369
Liver and Pancreas 230 | 16,750
Urinary Tract 230 | 16,678
Cardiovascular System 227 | 15,192

Target Family

Non-IDG 164 | 12,091
Enzyme 41 | 4,145
Transporter 13 | 473
GPCR 11 | 408
Kinase 9 | 634
Ion Channel 5 | 344

CSPA Cell Line

MelanomaAdh 243 | 243
U-251 MG 405 | 405
Glioblastoma 376 | 376
LN18 359 | 359
HEK 329 | 329
Melanoma NSph 305 | 305
U-2 OS 286 | 286
LN229 283 | 283
RD 277 | 277
T98G 276 | 276
Rh28 265 | 265
ZL55 MPM 262 | 262
HeLa 260 | 260
Adipocytes 259 | 259
B-ALL 255 | 255
A431 242 | 242
U-87 MG 242 | 242
Ruch-2 240 | 240
IMR-32 231 | 231
SDM104 228 | 228
P493-6 227 | 227
SDM5 221 | 221
L428 218 | 218
PASMC 217 | 217
CD4+CD25-Tcells 213 | 213
SDM4 211 | 211
KMH2 194 | 194
HDLM-2 193 | 193
HCC4012 192 | 192
MedB1 189 | 189
Jurkat 188 | 188
NK cells 182 | 182
NB4 181 | 181
L540 179 | 179
HBL-1 171 | 171
U2932 171 | 171
CaLu3 167 | 167
Lymphoma 163 | 163
SU-DHL-6 160 | 160
LNT229 154 | 154
SU4 (SU-DHL-4) 154 | 154
HL-60 146 | 146
786-O 112 | 112
SDM34 86 | 86
RH4 67 | 67
Braintumor 66 | 66
hMSC 59 | 59

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Integrin alpha-2 ITGA2 Tbio Non-IDG -2.58423 335.9 895
Protein disulfide-isomerase TMX3 TMX3 Tbio Enzyme -0.72922 5.29 80
HLA class I histocompatibility antigen, B-51 alpha chain HLA-B Tbio Non-IDG -1.88752 1613.5 0
Protein tweety homolog 3 TTYH3 Tbio Ion Channel -0.17609 1.56 17
Interleukin-6 receptor subunit beta IL6ST Tclin Non-IDG -1.72489 55.4 555
EMILIN-1 EMILIN1 Tbio Non-IDG -1.54226 36.3 0
Integrin alpha-9 ITGA9 Tbio Non-IDG -1.46619 29.0 124
Integrin beta-8 ITGB8 Tbio Non-IDG -1.47947 27.7 99
Integrin alpha-3 ITGA3 Tbio Non-IDG -2.08360 104.1 587