Development Level

Tbio 158 | 11,178
Tchem 50 | 1,885
Tdark 20 | 6,569
Tclin 15 | 612

Collection

GPCR: IDG Consortium (Complete... 2 | 25
GPCR: IDG Consortium (Targets) 1 | 126
Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

preweaning lethality, incomple... 11 | 499
preweaning lethality, complete... 8 | 979
increased lean body mass 6 | 172
abnormal behavior 5 | 298
decreased total body fat amoun... 5 | 207
increased bone mineral content 5 | 108
decreased startle reflex 4 | 75
decreased vertical activity 4 | 208
increased total body fat amoun... 4 | 134
abnormal coat appearance 3 | 31
abnormal embryo size 3 | 220
abnormal eye morphology 3 | 68
abnormal skin morphology 3 | 50
abnormal sleep behavior 3 | 70
decreased circulating glucose ... 3 | 126
decreased grip strength 3 | 116
embryonic lethality prior to t... 3 | 278
enlarged heart 3 | 210
hypoactivity 3 | 132
increased circulating choleste... 3 | 66
tremors 3 | 39
abnormal bone structure 2 | 187
abnormal coat-hair pigmentatio... 2 | 64
abnormal gait 2 | 69
abnormal limb bud morphology 2 | 17
abnormal seminal vesicle morph... 2 | 114
cardiovascular system phenotyp... 2 | 36
decreased body length 2 | 101
decreased body weight 2 | 161
decreased circulating triglyce... 2 | 79
decreased erythrocyte cell num... 2 | 62
decreased fasted circulating g... 2 | 65
decreased prepulse inhibition 2 | 82
enlarged spleen 2 | 41
hyperactivity 2 | 148
increased body weight 2 | 25
increased heart weight 2 | 62
increased mean corpuscular vol... 2 | 92
increased startle reflex 2 | 112
male infertility 2 | 123
pallor 2 | 34
abnormal behavioral response t... 1 | 66
abnormal ear morphology 1 | 9
abnormal epididymis morphology 1 | 42
abnormal femur morphology 1 | 14
abnormal head morphology 1 | 10
abnormal lung morphology 1 | 26
abnormal pericardium morpholog... 1 | 26
abnormal placenta size 1 | 20
abnormal retina morphology 1 | 71
abnormal snout morphology 1 | 23
abnormal startle reflex 1 | 15
abnormal tail movements 1 | 12
abnormal urinary bladder morph... 1 | 11
abnormal vibrissa morphology 1 | 25
absent startle reflex 1 | 24
absent vibrissae 1 | 12
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased cardiac muscle contr... 1 | 11
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating phosphat... 1 | 27
decreased eosinophil cell numb... 1 | 24
decreased exploration in new e... 1 | 11
decreased heart rate 1 | 18
decreased heart rate variabili... 1 | 13
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 31
decreased mean platelet volume 1 | 25
edema 1 | 59
embryonic growth retardation 1 | 106
enlarged epididymis 1 | 31
enlarged lymph nodes 1 | 37
hemorrhage 1 | 23
impaired glucose tolerance 1 | 75
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating creatini... 1 | 38
increased circulating glycerol... 1 | 9
increased circulating iron lev... 1 | 30
increased circulating triglyce... 1 | 42
increased exploration in new e... 1 | 8
increased fasted circulating g... 1 | 76
increased heart rate 1 | 23
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased mean platelet volume 1 | 45
long tibia 1 | 25
pale yolk sac 1 | 25
persistence of hyaloid vascula... 1 | 33
premature death 1 | 5
prenatal lethality prior to he... 1 | 87
prolonged PQ interval 1 | 5
unresponsive to tactile stimul... 1 | 8
vertebral fusion 1 | 23

Disease

Carcinoma 178 | 11,192
ovarian cancer 150 | 8,297
osteosarcoma 130 | 7,766
glioblastoma 125 | 5,635
medulloblastoma, large-cell 104 | 6,086
psoriasis 104 | 6,514
lung cancer 92 | 4,607
atypical teratoid / rhabdoid tumor 91 | 4,971
ependymoma 91 | 4,559
Astrocytoma, Pilocytic 86 | 3,006
Breast cancer 81 | 3,469
Cancer 79 | 2,388
invasive ductal carcinoma 78 | 2,867
malignant mesothelioma 78 | 3,135
non-small cell lung cancer 69 | 2,799
intraductal papillary-mucinous adenoma (IPMA) 68 | 2,872
intraductal papillary-mucinous neoplasm (IPMN) 68 | 3,204
lung carcinoma 68 | 2,755
pancreatic cancer 67 | 2,322
adult high grade glioma 66 | 3,701
oligodendroglioma 65 | 2,768
group 3 medulloblastoma 63 | 4,002
interstitial cystitis 63 | 2,237
lung adenocarcinoma 63 | 2,627
intraductal papillary-mucinous carcinoma (IPMC) 60 | 2,902
Kidney cancer 56 | 2,548
ulcerative colitis 56 | 1,765
subependymal giant cell astrocytoma 54 | 2,230
cystic fibrosis 51 | 1,629
astrocytic glioma 49 | 2,530
diabetes mellitus 49 | 1,683
pancreatic ductal adenocarcinoma liver metastasis 46 | 1,911
primitive neuroectodermal tumor 46 | 2,957
ductal carcinoma in situ 45 | 1,686
tuberculosis 44 | 1,963
primary pancreatic ductal adenocarcinoma 41 | 1,071
breast carcinoma 40 | 1,589
colon cancer 40 | 1,428
juvenile dermatomyositis 39 | 1,147
gastric carcinoma 38 | 781
Pick disease 37 | 1,856
pituitary cancer 36 | 1,915
Autosomal recessive predisposition 35 | 1,407
group 4 medulloblastoma 35 | 1,806
Duchenne muscular dystrophy 34 | 587
adrenocortical carcinoma 34 | 1,385
dermatomyositis 34 | 941
acute quadriplegic myopathy 28 | 1,133
pediatric high grade glioma 28 | 1,035
Rheumatoid arthritis 27 | 1,156
Multiple myeloma 26 | 1,296
Schizophrenia 26 | 1,136
astrocytoma 26 | 1,113
Multiple Sclerosis 25 | 527
Alzheimer's disease 24 | 640
Down syndrome 24 | 480
active Crohn's disease 24 | 882
esophageal adenocarcinoma 24 | 696
cutaneous lupus erythematosus 23 | 1,016
nasopharyngeal carcinoma 22 | 1,024
autosomal dominant Emery-Dreifuss muscular dystrophy 21 | 492
Breast Neoplasms 18 | 423
Endometriosis 18 | 521
Intellectual disability 18 | 998
Mammary Neoplasms 18 | 403
active ulcerative colitis 18 | 736
fibroadenoma 18 | 538
Melanoma 17 | 689
aldosterone-producing adenoma 17 | 646
progressive supranuclear palsy 17 | 656
Waldenstrons macroglobulinemia 16 | 742
Atopic dermatitis 15 | 915
Hypersensitivity reaction type II disease 15 | 245
mucosa-associated lymphoid tissue lymphoma 15 | 473
sonic hedgehog group medulloblastoma 15 | 459
Dull intelligence 14 | 634
Liver Cirrhosis, Experimental 14 | 733
Liver cancer 14 | 589
Low intelligence 14 | 634
Mental Retardation 14 | 634
Mental deficiency 14 | 634
Poor school performance 14 | 634
Vascular disease 14 | 294
medulloblastoma 14 | 702
non primary Sjogren syndrome sicca 14 | 861
posterior fossa group A ependymoma 14 | 456
primary Sjogren syndrome 14 | 710
spina bifida 14 | 1,053
Autistic Disorder 13 | 358
Kidney disease 13 | 411
Muscle hypotonia 13 | 562
acute myeloid leukemia 13 | 760
Arthritis 12 | 276
Atherosclerosis 12 | 276
Becker muscular dystrophy 12 | 184
Neoplasm Invasiveness 12 | 151
Prostatic Neoplasms 12 | 472
interstitial lung disease 12 | 287
Bipolar Disorder 11 | 646
Mental Depression 11 | 325

Tissue

Endocrine System 232 | 18,159
Female tissues 232 | 17,400
Skin and soft tissues 232 | 17,230
Blood and immune system 231 | 16,909
Male tissues 231 | 17,142
Nervous System 231 | 16,725
Respiratory system 231 | 16,393
Digestive Tract 230 | 17,369
Liver and Pancreas 230 | 16,750
Urinary Tract 230 | 16,678
Cardiovascular System 227 | 15,192

Target Family

Non-IDG 164 | 12,091
Enzyme 41 | 4,145
Transporter 13 | 473
GPCR 11 | 408
Kinase 9 | 634
Ion Channel 5 | 344

CSPA Cell Line

MelanomaAdh 243 | 243
U-251 MG 405 | 405
Glioblastoma 376 | 376
LN18 359 | 359
HEK 329 | 329
Melanoma NSph 305 | 305
U-2 OS 286 | 286
LN229 283 | 283
RD 277 | 277
T98G 276 | 276
Rh28 265 | 265
ZL55 MPM 262 | 262
HeLa 260 | 260
Adipocytes 259 | 259
B-ALL 255 | 255
A431 242 | 242
U-87 MG 242 | 242
Ruch-2 240 | 240
IMR-32 231 | 231
SDM104 228 | 228
P493-6 227 | 227
SDM5 221 | 221
L428 218 | 218
PASMC 217 | 217
CD4+CD25-Tcells 213 | 213
SDM4 211 | 211
KMH2 194 | 194
HDLM-2 193 | 193
HCC4012 192 | 192
MedB1 189 | 189
Jurkat 188 | 188
NK cells 182 | 182
NB4 181 | 181
L540 179 | 179
HBL-1 171 | 171
U2932 171 | 171
CaLu3 167 | 167
Lymphoma 163 | 163
SU-DHL-6 160 | 160
LNT229 154 | 154
SU4 (SU-DHL-4) 154 | 154
HL-60 146 | 146
786-O 112 | 112
SDM34 86 | 86
RH4 67 | 67
Braintumor 66 | 66
hMSC 59 | 59

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dystroglycan DAG1 Tbio Enzyme -2.77503 560.0 254
Protocadherin-7 PCDH7 Tbio Non-IDG -1.42056 26.3 248
Cathepsin D CTSD Tchem Enzyme -3.47061 2866.8 779
Thromboxane A2 receptor TBXA2R Tclin GPCR -2.17674 123.4 112
Scavenger receptor class F member 2 SCARF2 Tbio Non-IDG -1.42517 27.8 84
Leucine-rich repeat and fibronectin type III domain-containing protein 1 LRFN1 Tdark Non-IDG -0.40499 2.43 58
Uncharacterized protein C1orf159 C1orf159 Tdark Non-IDG 0.95 0.11 84
Translocon-associated protein subunit beta SSR2 Tbio Non-IDG -1.59509 38.4 129
Sortilin SORT1 Tchem Non-IDG -2.36389 235.8 137
Major prion protein PRNP Tchem Non-IDG -3.45326 5611.1 484