Development Level

Tbio 102 | 11,445
Tchem 25 | 1,598
Tclin 19 | 613
Tdark 8 | 6,588

Collection

GPCR: IDG Consortium (Complete... 1 | 25
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, incomple... 6 | 499
abnormal behavior 5 | 298
preweaning lethality, complete... 5 | 979
decreased total body fat amoun... 4 | 207
enlarged heart 4 | 210
increased heart weight 4 | 62
decreased vertical activity 3 | 208
increased circulating triglyce... 3 | 42
abnormal bone structure 2 | 187
abnormal embryo size 2 | 220
abnormal heart morphology 2 | 162
abnormal seminal vesicle morph... 2 | 114
decreased body length 2 | 101
decreased cardiac muscle contr... 2 | 11
decreased eosinophil cell numb... 2 | 24
enlarged spleen 2 | 41
improved glucose tolerance 2 | 79
increased bone mineral content 2 | 108
increased circulating choleste... 2 | 66
increased lean body mass 2 | 172
increased mean corpuscular vol... 2 | 92
increased total body fat amoun... 2 | 134
tremors 2 | 39
abnormal anxiety-related respo... 1 | 1
abnormal coat appearance 1 | 31
abnormal coat-hair pigmentatio... 1 | 64
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal ear morphology 1 | 9
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal facial morphology 1 | 17
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal head shape 1 | 10
abnormal humerus morphology 1 | 11
abnormal limb bud morphology 1 | 17
abnormal limb morphology 1 | 13
abnormal liver morphology 1 | 17
abnormal neural tube closure 1 | 46
abnormal response to new envir... 1 | 10
abnormal skin morphology 1 | 50
abnormal social-conspecific in... 1 | 3
abnormal tail morphology 1 | 25
abnormal tail movements 1 | 12
abnormal testis morphology 1 | 43
abnormal urination 1 | 1
absent startle reflex 1 | 24
absent vibrissae 1 | 12
cardiovascular system phenotyp... 1 | 36
decreased basophil cell number 1 | 16
decreased blood urea nitrogen ... 1 | 51
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating phosphat... 1 | 27
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased heart rate 1 | 18
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 31
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
dilated heart left ventricle 1 | 11
edema 1 | 59
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged epididymis 1 | 31
enlarged lymph nodes 1 | 37
hemorrhage 1 | 23
hydrometra 1 | 53
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased body length 1 | 32
increased body weight 1 | 25
increased bone mineral density 1 | 72
increased circulating iron lev... 1 | 30
increased erythrocyte cell num... 1 | 39
increased exploration in new e... 1 | 8
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 96
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
male infertility 1 | 123
prolonged PQ interval 1 | 5
prolonged QT interval 1 | 38
small superior vagus ganglion 1 | 74
small testis 1 | 58
spina bifida 1 | 2
syndactyly 1 | 23
thrombocytopenia 1 | 56
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 124 | 11,493
ovarian cancer 101 | 8,520
glioblastoma 94 | 5,792
osteosarcoma 86 | 7,950
Cancer 77 | 2,499
ependymoma 70 | 4,679
atypical teratoid / rhabdoid tumor 69 | 5,112
Astrocytoma, Pilocytic 67 | 3,081
lung cancer 66 | 4,740
psoriasis 66 | 6,694
malignant mesothelioma 64 | 3,232
medulloblastoma, large-cell 64 | 6,241
lung carcinoma 62 | 2,843
adult high grade glioma 61 | 3,801
invasive ductal carcinoma 60 | 2,951
Breast cancer 57 | 3,578
pancreatic cancer 56 | 2,398
non-small cell lung cancer 55 | 2,890
interstitial cystitis 53 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 53 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 48 | 3,291
cystic fibrosis 47 | 1,696
group 3 medulloblastoma 47 | 4,104
lung adenocarcinoma 47 | 2,716
ulcerative colitis 47 | 1,819
primary pancreatic ductal adenocarcinoma 46 | 1,109
intraductal papillary-mucinous carcinoma (IPMC) 44 | 2,989
oligodendroglioma 43 | 2,850
Kidney cancer 41 | 2,613
primitive neuroectodermal tumor 39 | 3,035
ductal carcinoma in situ 38 | 1,745
tuberculosis 38 | 2,010
subependymal giant cell astrocytoma 37 | 2,287
gastric carcinoma 34 | 807
astrocytic glioma 31 | 2,597
colon cancer 30 | 1,478
diabetes mellitus 30 | 1,728
juvenile dermatomyositis 30 | 1,187
Duchenne muscular dystrophy 28 | 601
adrenocortical carcinoma 28 | 1,428
breast carcinoma 28 | 1,638
group 4 medulloblastoma 27 | 1,855
Autosomal recessive predisposition 24 | 1,442
pancreatic ductal adenocarcinoma liver metastasis 24 | 1,962
autosomal dominant Emery-Dreifuss muscular dystrophy 22 | 510
dermatomyositis 22 | 966
nasopharyngeal carcinoma 21 | 1,058
pituitary cancer 21 | 1,972
Pick disease 20 | 1,894
acute quadriplegic myopathy 20 | 1,158
pediatric high grade glioma 20 | 1,064
Atopic dermatitis 19 | 952
Schizophrenia 19 | 1,160
Breast Neoplasms 18 | 445
astrocytoma 18 | 1,146
cutaneous lupus erythematosus 18 | 1,057
esophageal adenocarcinoma 18 | 737
Mammary Neoplasms 17 | 425
Liver Cirrhosis, Experimental 16 | 769
fibroadenoma 16 | 559
Endometriosis 15 | 540
Vascular disease 15 | 319
Down syndrome 14 | 499
Multiple Sclerosis 14 | 540
aldosterone-producing adenoma 14 | 665
Prostatic Neoplasms 13 | 495
Rheumatoid arthritis 13 | 1,191
active Crohn's disease 13 | 922
active ulcerative colitis 13 | 764
acute myeloid leukemia 13 | 783
spina bifida 13 | 1,074
Alzheimer's disease 12 | 658
Kidney disease 12 | 430
Multiple myeloma 12 | 1,332
Arthritis 11 | 290
Atherosclerosis 11 | 291
Barrett's esophagus 11 | 182
Hypersensitivity reaction type II disease 11 | 253
Melanoma 11 | 711
Neoplasm Invasiveness 11 | 161
Neoplasm Metastasis 11 | 168
posterior fossa group A ependymoma 11 | 468
primary Sjogren syndrome 11 | 735
Becker muscular dystrophy 10 | 191
Hypertension 10 | 396
Liver disease 10 | 237
Mammary Neoplasms, Experimental 10 | 154
interstitial lung disease 10 | 298
progressive supranuclear palsy 10 | 676
sonic hedgehog group medulloblastoma 10 | 467
Anemia 9 | 365
Cerebrovascular disease 9 | 238
Coronary artery disease 9 | 268
Diabetes Mellitus, Non-Insulin-Dependent 9 | 145
Disease Progression 9 | 136
Hypertensive disease 9 | 292
Skin cancer 9 | 469
Stomach Neoplasms 9 | 300
Waldenstrons macroglobulinemia 9 | 765
mucosa-associated lymphoid tissue lymphoma 9 | 484

Tissue

Blood and immune system 151 | 16,909
Endocrine System 151 | 18,159
Female tissues 151 | 17,400
Urinary Tract 151 | 16,678
Cardiovascular System 150 | 15,192
Digestive Tract 150 | 17,369
Liver and Pancreas 150 | 16,750
Male tissues 150 | 17,142
Nervous System 150 | 16,725
Respiratory system 150 | 16,393
Skin and soft tissues 150 | 17,230

Target Family

Non-IDG 111 | 12,091
Enzyme 18 | 4,145
Kinase 12 | 634
Transporter 8 | 473
GPCR 4 | 408
Ion Channel 1 | 344

CSPA Cell Line

LNT229 154 | 154
U-251 MG 405 | 405
Glioblastoma 376 | 376
LN18 359 | 359
HEK 329 | 329
Melanoma NSph 305 | 305
U-2 OS 286 | 286
LN229 283 | 283
RD 277 | 277
T98G 276 | 276
Rh28 265 | 265
ZL55 MPM 262 | 262
HeLa 260 | 260
Adipocytes 259 | 259
B-ALL 255 | 255
MelanomaAdh 243 | 243
A431 242 | 242
U-87 MG 242 | 242
Ruch-2 240 | 240
IMR-32 231 | 231
SDM104 228 | 228
P493-6 227 | 227
SDM5 221 | 221
L428 218 | 218
PASMC 217 | 217
CD4+CD25-Tcells 213 | 213
SDM4 211 | 211
KMH2 194 | 194
HDLM-2 193 | 193
HCC4012 192 | 192
MedB1 189 | 189
Jurkat 188 | 188
NK cells 182 | 182
NB4 181 | 181
L540 179 | 179
HBL-1 171 | 171
U2932 171 | 171
CaLu3 167 | 167
Lymphoma 163 | 163
SU-DHL-6 160 | 160
SU4 (SU-DHL-4) 154 | 154
HL-60 146 | 146
786-O 112 | 112
SDM34 86 | 86
RH4 67 | 67
Braintumor 66 | 66
hMSC 59 | 59

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Neuroplastin NPTN Tbio Non-IDG -2.31075 211.6 201
CD109 antigen CD109 Tbio Non-IDG -1.85817 77.8 239
Protein HEG homolog 1 HEG1 Tbio Non-IDG -2.11308 129.3 11
Sodium bicarbonate cotransporter 3 SLC4A7 Tbio Transporter -1.82039 64.7 133
Trophoblast glycoprotein TPBG Tbio Non-IDG -2.10560 136.9 206
UL-16 binding protein 5 RAET1G Tbio Non-IDG -0.77225 5.67 20
CD276 antigen CD276 Tbio Non-IDG -3.03140 785.5 481
Zinc transporter ZIP6 SLC39A6 Tbio Transporter -1.66663 50.0 172
Adhesion G protein-coupled receptor E2 ADGRE2 Tbio GPCR -1.67862 48.2 312