Development Level

Tbio 225 | 11,178
Tchem 68 | 1,885
Tclin 33 | 612
Tdark 33 | 6,569

Collection

GPCR: IDG Consortium (Targets) 5 | 126
GPCR: IDG Consortium (Complete... 4 | 25

IMPC Phenotype

preweaning lethality, complete... 18 | 979
preweaning lethality, incomple... 15 | 499
abnormal behavior 12 | 298
embryonic lethality prior to t... 9 | 278
decreased total body fat amoun... 8 | 207
enlarged heart 6 | 210
abnormal bone structure 5 | 187
abnormal embryo size 5 | 220
decreased bone mineral content 5 | 151
decreased grip strength 5 | 116
decreased vertical activity 5 | 208
improved glucose tolerance 5 | 79
increased heart weight 5 | 62
increased lean body mass 5 | 172
increased total body fat amoun... 5 | 134
abnormal limb bud morphology 4 | 17
abnormal pericardium morpholog... 4 | 26
decreased body length 4 | 101
decreased body weight 4 | 161
embryonic lethality prior to o... 4 | 239
impaired glucose tolerance 4 | 75
increased bone mineral content 4 | 108
abnormal eye morphology 3 | 68
abnormal gait 3 | 69
abnormal sleep behavior 3 | 70
abnormal snout morphology 3 | 23
cardiovascular system phenotyp... 3 | 36
decreased bone mineral density 3 | 126
decreased circulating choleste... 3 | 93
decreased lean body mass 3 | 135
decreased leukocyte cell numbe... 3 | 73
embryonic growth retardation 3 | 106
enlarged spleen 3 | 41
hyperactivity 3 | 148
increased circulating choleste... 3 | 66
increased erythrocyte cell num... 3 | 39
increased fasted circulating g... 3 | 76
increased leukocyte cell numbe... 3 | 47
increased mean corpuscular vol... 3 | 92
increased vertical activity 3 | 24
male infertility 3 | 123
pale yolk sac 3 | 25
pallor 3 | 34
tremors 3 | 39
abnormal behavioral response t... 2 | 66
abnormal coat appearance 2 | 31
abnormal coat-hair pigmentatio... 2 | 64
abnormal cranium morphology 2 | 36
abnormal ear morphology 2 | 9
abnormal embryo turning 2 | 31
abnormal heart morphology 2 | 162
abnormal kidney morphology 2 | 65
abnormal limb position 2 | 3
abnormal neural tube closure 2 | 46
abnormal seminal vesicle morph... 2 | 114
abnormal skin morphology 2 | 50
cataract 2 | 92
decreased cardiac muscle contr... 2 | 11
decreased circulating HDL chol... 2 | 68
decreased circulating glucose ... 2 | 126
decreased circulating glycerol... 2 | 16
decreased circulating triglyce... 2 | 79
decreased erythrocyte cell num... 2 | 62
decreased fasted circulating g... 2 | 65
decreased heart rate 2 | 18
decreased mean corpuscular hem... 2 | 50
decreased mean corpuscular vol... 2 | 79
decreased prepulse inhibition 2 | 82
decreased startle reflex 2 | 75
enlarged uterus 2 | 11
increased circulating alkaline... 2 | 122
increased circulating glycerol... 2 | 9
increased circulating thyroxin... 2 | 7
increased hemoglobin content 2 | 45
increased mean corpuscular hem... 2 | 96
polycystic kidney 2 | 15
short tibia 2 | 97
abnormal craniofacial morpholo... 1 | 33
abnormal lens morphology 1 | 81
abnormal neural tube morpholog... 1 | 12
abnormal startle reflex 1 | 15
abnormal tail movements 1 | 12
abnormal tooth morphology 1 | 24
abnormal vocalization 1 | 21
decreased blood urea nitrogen ... 1 | 51
decreased exploration in new e... 1 | 11
dilated heart left ventricle 1 | 11
enlarged lymph nodes 1 | 37
hydrometra 1 | 53
impaired righting response 1 | 26
increased aggression 1 | 4
increased blood urea nitrogen ... 1 | 48
increased circulating HDL chol... 1 | 80
increased circulating creatini... 1 | 38
increased eosinophil cell numb... 1 | 11
increased exploration in new e... 1 | 8
limb grasping 1 | 41
premature death 1 | 5
small superior vagus ganglion 1 | 74
trunk curl 1 | 16

Disease

Carcinoma 259 | 11,192
ovarian cancer 226 | 8,297
osteosarcoma 188 | 7,766
glioblastoma 187 | 5,635
medulloblastoma, large-cell 165 | 6,086
psoriasis 161 | 6,514
atypical teratoid / rhabdoid tumor 149 | 4,971
ependymoma 147 | 4,559
malignant mesothelioma 139 | 3,135
lung cancer 133 | 4,607
lung carcinoma 130 | 2,755
Cancer 129 | 2,388
Breast cancer 127 | 3,469
invasive ductal carcinoma 117 | 2,867
Astrocytoma, Pilocytic 114 | 3,006
non-small cell lung cancer 111 | 2,799
intraductal papillary-mucinous neoplasm (IPMN) 106 | 3,204
pancreatic cancer 106 | 2,322
group 3 medulloblastoma 105 | 4,002
intraductal papillary-mucinous adenoma (IPMA) 105 | 2,872
intraductal papillary-mucinous carcinoma (IPMC) 102 | 2,902
adult high grade glioma 97 | 3,701
lung adenocarcinoma 95 | 2,627
Kidney cancer 90 | 2,548
interstitial cystitis 89 | 2,237
oligodendroglioma 88 | 2,768
ulcerative colitis 88 | 1,765
subependymal giant cell astrocytoma 83 | 2,230
cystic fibrosis 75 | 1,629
primitive neuroectodermal tumor 72 | 2,957
astrocytic glioma 71 | 2,530
ductal carcinoma in situ 71 | 1,686
breast carcinoma 68 | 1,589
tuberculosis 68 | 1,963
pancreatic ductal adenocarcinoma liver metastasis 65 | 1,911
primary pancreatic ductal adenocarcinoma 63 | 1,071
diabetes mellitus 59 | 1,683
group 4 medulloblastoma 59 | 1,806
pituitary cancer 59 | 1,915
juvenile dermatomyositis 57 | 1,147
adrenocortical carcinoma 53 | 1,385
gastric carcinoma 52 | 781
colon cancer 51 | 1,428
astrocytoma 45 | 1,113
Autosomal recessive predisposition 44 | 1,407
Duchenne muscular dystrophy 44 | 587
Pick disease 44 | 1,856
pediatric high grade glioma 44 | 1,035
dermatomyositis 41 | 941
acute quadriplegic myopathy 40 | 1,133
cutaneous lupus erythematosus 40 | 1,016
esophageal adenocarcinoma 39 | 696
Schizophrenia 37 | 1,136
Rheumatoid arthritis 35 | 1,156
fibroadenoma 33 | 538
Liver Cirrhosis, Experimental 32 | 733
autosomal dominant Emery-Dreifuss muscular dystrophy 32 | 492
nasopharyngeal carcinoma 32 | 1,024
Multiple Sclerosis 31 | 527
Multiple myeloma 31 | 1,296
active Crohn's disease 30 | 882
Alzheimer's disease 29 | 640
Atopic dermatitis 29 | 915
Down syndrome 26 | 480
Melanoma 26 | 689
Breast Neoplasms 24 | 423
Skin cancer 24 | 451
primary Sjogren syndrome 24 | 710
Liver cancer 23 | 589
Mammary Neoplasms 23 | 403
aldosterone-producing adenoma 23 | 646
Hypersensitivity reaction type II disease 22 | 245
active ulcerative colitis 22 | 736
posterior fossa group A ependymoma 22 | 456
spina bifida 22 | 1,053
Atherosclerosis 21 | 276
Intellectual disability 21 | 998
Prostatic Neoplasms 21 | 472
acute myeloid leukemia 21 | 760
medulloblastoma 21 | 702
Endometriosis 20 | 521
Asthma 19 | 370
Kidney disease 19 | 411
Liver disease 19 | 227
Arthritis 18 | 276
Coronary artery disease 18 | 253
Dull intelligence 18 | 634
Hypertension 18 | 372
Low intelligence 18 | 634
Mental Retardation 18 | 634
Mental deficiency 18 | 634
Neoplasm Invasiveness 18 | 151
Poor school performance 18 | 634
Stomach Neoplasms 18 | 287
mucosa-associated lymphoid tissue lymphoma 18 | 473
sonic hedgehog group medulloblastoma 18 | 459
Obesity 17 | 655
interstitial lung disease 17 | 287
Becker muscular dystrophy 16 | 184
Vascular disease 16 | 294

Tissue

Urinary Tract 352 | 16,678
Endocrine System 351 | 18,159
Male tissues 351 | 17,142
Digestive Tract 350 | 17,369
Female tissues 350 | 17,400
Liver and Pancreas 349 | 16,750
Nervous System 349 | 16,725
Skin and soft tissues 349 | 17,230
Blood and immune system 347 | 16,909
Respiratory system 347 | 16,393
Cardiovascular System 340 | 15,192

Target Family

Non-IDG 240 | 12,091
Enzyme 43 | 4,145
Transporter 24 | 473
GPCR 23 | 408
Kinase 20 | 634
Ion Channel 7 | 344
Transcription Factor 2 | 1,400

CSPA Cell Line

LN18 359 | 359
U-251 MG 405 | 405
Glioblastoma 376 | 376
HEK 329 | 329
Melanoma NSph 305 | 305
U-2 OS 286 | 286
LN229 283 | 283
RD 277 | 277
T98G 276 | 276
Rh28 265 | 265
ZL55 MPM 262 | 262
HeLa 260 | 260
Adipocytes 259 | 259
B-ALL 255 | 255
MelanomaAdh 243 | 243
A431 242 | 242
U-87 MG 242 | 242
Ruch-2 240 | 240
IMR-32 231 | 231
SDM104 228 | 228
P493-6 227 | 227
SDM5 221 | 221
L428 218 | 218
PASMC 217 | 217
CD4+CD25-Tcells 213 | 213
SDM4 211 | 211
KMH2 194 | 194
HDLM-2 193 | 193
HCC4012 192 | 192
MedB1 189 | 189
Jurkat 188 | 188
NK cells 182 | 182
NB4 181 | 181
L540 179 | 179
HBL-1 171 | 171
U2932 171 | 171
CaLu3 167 | 167
Lymphoma 163 | 163
SU-DHL-6 160 | 160
LNT229 154 | 154
SU4 (SU-DHL-4) 154 | 154
HL-60 146 | 146
786-O 112 | 112
SDM34 86 | 86
RH4 67 | 67
Braintumor 66 | 66
hMSC 59 | 59

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dystroglycan DAG1 Tbio Enzyme -2.77503 560.0 254
Protocadherin-7 PCDH7 Tbio Non-IDG -1.42056 26.3 248
Cathepsin D CTSD Tchem Enzyme -3.47061 2866.8 779
Insulin receptor INSR Tclin Kinase -2.50045 306.8 1417
Synaptic vesicle glycoprotein 2A SV2A Tclin Non-IDG -2.60937 395.1 107
Fukutin-related protein FKRP Tbio Non-IDG -2.01629 107.6 173
Beta-2 adrenergic receptor ADRB2 Tclin GPCR -3.22695 1680.9 829
Prostaglandin F2 receptor negative regulator PTGFRN Tbio Non-IDG -1.42165 26.8 105
Microfibril-associated glycoprotein 3 MFAP3 Tdark Non-IDG 0.15 0.82 94
Transmembrane protein 132A TMEM132A Tdark Non-IDG -0.23045 2.47 54