Development Level

Tbio 248 | 11,651
Tchem 45 | 1,388
Tclin 33 | 612
Tdark 33 | 6,593

Collection

GPCR: IDG Consortium (Targets) 5 | 126
RFA-RM-18-021 5 | 328
GPCR: IDG Consortium (Complete... 4 | 25

IMPC Phenotype

preweaning lethality, complete... 18 | 979
preweaning lethality, incomple... 15 | 499
abnormal behavior 12 | 298
embryonic lethality prior to t... 9 | 278
decreased total body fat amoun... 8 | 207
enlarged heart 6 | 210
abnormal bone structure 5 | 187
abnormal embryo size 5 | 220
decreased bone mineral content 5 | 151
decreased grip strength 5 | 116
decreased vertical activity 5 | 208
improved glucose tolerance 5 | 79
increased heart weight 5 | 62
increased lean body mass 5 | 172
increased total body fat amoun... 5 | 134
abnormal limb bud morphology 4 | 17
abnormal pericardium morpholog... 4 | 26
decreased body length 4 | 101
decreased body weight 4 | 161
embryonic lethality prior to o... 4 | 239
impaired glucose tolerance 4 | 75
increased bone mineral content 4 | 108
abnormal eye morphology 3 | 68
abnormal gait 3 | 69
abnormal sleep behavior 3 | 70
abnormal snout morphology 3 | 23
cardiovascular system phenotyp... 3 | 36
decreased bone mineral density 3 | 126
decreased circulating choleste... 3 | 93
decreased lean body mass 3 | 135
decreased leukocyte cell numbe... 3 | 73
embryonic growth retardation 3 | 106
enlarged spleen 3 | 41
hyperactivity 3 | 148
increased circulating choleste... 3 | 66
increased erythrocyte cell num... 3 | 39
increased fasted circulating g... 3 | 76
increased leukocyte cell numbe... 3 | 47
increased mean corpuscular vol... 3 | 92
increased vertical activity 3 | 24
male infertility 3 | 123
pale yolk sac 3 | 25
pallor 3 | 34
tremors 3 | 39
abnormal behavioral response t... 2 | 66
abnormal coat appearance 2 | 31
abnormal coat-hair pigmentatio... 2 | 64
abnormal cranium morphology 2 | 36
abnormal ear morphology 2 | 9
abnormal embryo turning 2 | 31
abnormal heart morphology 2 | 162
abnormal kidney morphology 2 | 65
abnormal limb position 2 | 3
abnormal neural tube closure 2 | 46
abnormal seminal vesicle morph... 2 | 114
abnormal skin morphology 2 | 50
cataract 2 | 92
decreased cardiac muscle contr... 2 | 11
decreased circulating HDL chol... 2 | 68
decreased circulating glucose ... 2 | 126
decreased circulating glycerol... 2 | 16
decreased circulating triglyce... 2 | 79
decreased erythrocyte cell num... 2 | 62
decreased fasted circulating g... 2 | 65
decreased heart rate 2 | 18
decreased mean corpuscular hem... 2 | 50
decreased mean corpuscular vol... 2 | 79
decreased prepulse inhibition 2 | 82
decreased startle reflex 2 | 75
enlarged uterus 2 | 11
increased circulating alkaline... 2 | 122
increased circulating glycerol... 2 | 9
increased circulating thyroxin... 2 | 7
increased hemoglobin content 2 | 45
increased mean corpuscular hem... 2 | 96
polycystic kidney 2 | 15
short tibia 2 | 97
abnormal craniofacial morpholo... 1 | 33
abnormal lens morphology 1 | 81
abnormal neural tube morpholog... 1 | 12
abnormal startle reflex 1 | 15
abnormal tail movements 1 | 12
abnormal tooth morphology 1 | 24
abnormal vocalization 1 | 21
decreased blood urea nitrogen ... 1 | 51
decreased exploration in new e... 1 | 11
dilated heart left ventricle 1 | 11
enlarged lymph nodes 1 | 37
hydrometra 1 | 53
impaired righting response 1 | 26
increased aggression 1 | 4
increased blood urea nitrogen ... 1 | 48
increased circulating HDL chol... 1 | 80
increased circulating creatini... 1 | 38
increased eosinophil cell numb... 1 | 11
increased exploration in new e... 1 | 8
limb grasping 1 | 41
premature death 1 | 5
small superior vagus ganglion 1 | 74
trunk curl 1 | 16

Disease

Carcinoma 275 | 11,493
ovarian cancer 238 | 8,520
glioblastoma 198 | 5,792
osteosarcoma 198 | 7,950
medulloblastoma, large-cell 173 | 6,241
psoriasis 165 | 6,694
atypical teratoid / rhabdoid tumor 160 | 5,112
ependymoma 155 | 4,679
malignant mesothelioma 143 | 3,232
lung cancer 141 | 4,740
Cancer 138 | 2,499
lung carcinoma 138 | 2,843
Breast cancer 137 | 3,578
invasive ductal carcinoma 125 | 2,951
Astrocytoma, Pilocytic 121 | 3,081
non-small cell lung cancer 118 | 2,890
pancreatic cancer 115 | 2,398
group 3 medulloblastoma 112 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 112 | 3,291
intraductal papillary-mucinous adenoma (IPMA) 110 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 110 | 2,989
adult high grade glioma 103 | 3,801
lung adenocarcinoma 102 | 2,716
Kidney cancer 96 | 2,613
oligodendroglioma 94 | 2,850
ulcerative colitis 94 | 1,819
interstitial cystitis 91 | 2,312
subependymal giant cell astrocytoma 88 | 2,287
cystic fibrosis 80 | 1,696
ductal carcinoma in situ 77 | 1,745
primitive neuroectodermal tumor 77 | 3,035
astrocytic glioma 74 | 2,597
breast carcinoma 71 | 1,638
primary pancreatic ductal adenocarcinoma 71 | 1,109
tuberculosis 71 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 66 | 1,962
juvenile dermatomyositis 63 | 1,187
group 4 medulloblastoma 61 | 1,855
pituitary cancer 61 | 1,972
diabetes mellitus 60 | 1,728
colon cancer 56 | 1,478
gastric carcinoma 56 | 807
adrenocortical carcinoma 55 | 1,428
Duchenne muscular dystrophy 48 | 601
astrocytoma 48 | 1,146
Pick disease 47 | 1,894
Autosomal recessive predisposition 46 | 1,442
acute quadriplegic myopathy 46 | 1,158
pediatric high grade glioma 46 | 1,064
cutaneous lupus erythematosus 45 | 1,057
esophageal adenocarcinoma 44 | 737
dermatomyositis 42 | 966
Rheumatoid arthritis 40 | 1,191
Liver Cirrhosis, Experimental 38 | 769
Schizophrenia 37 | 1,160
autosomal dominant Emery-Dreifuss muscular dystrophy 36 | 510
nasopharyngeal carcinoma 35 | 1,058
Alzheimer's disease 34 | 658
active Crohn's disease 34 | 922
fibroadenoma 34 | 559
Multiple Sclerosis 33 | 540
Multiple myeloma 33 | 1,332
Atopic dermatitis 30 | 952
Melanoma 28 | 711
primary Sjogren syndrome 27 | 735
Breast Neoplasms 26 | 445
Down syndrome 26 | 499
Hypersensitivity reaction type II disease 25 | 253
Liver cancer 25 | 604
Mammary Neoplasms 25 | 425
Skin cancer 25 | 469
active ulcerative colitis 25 | 764
aldosterone-producing adenoma 24 | 665
Endometriosis 23 | 540
Prostatic Neoplasms 23 | 495
acute myeloid leukemia 23 | 783
posterior fossa group A ependymoma 23 | 468
spina bifida 23 | 1,074
Asthma 22 | 385
Atherosclerosis 22 | 291
Intellectual disability 22 | 1,016
Kidney disease 22 | 430
Hypertension 21 | 396
medulloblastoma 21 | 720
Arthritis 20 | 290
Liver disease 20 | 237
Obesity 20 | 678
Stomach Neoplasms 20 | 300
Vascular disease 20 | 319
sonic hedgehog group medulloblastoma 20 | 467
Anemia 19 | 365
Neoplasm Invasiveness 19 | 161
mucosa-associated lymphoid tissue lymphoma 19 | 484
Coronary artery disease 18 | 268
Dull intelligence 18 | 645
Low intelligence 18 | 645
Mental Retardation 18 | 645
Mental deficiency 18 | 645
Poor school performance 18 | 645
Becker muscular dystrophy 17 | 191

Tissue

Urinary Tract 352 | 16,678
Endocrine System 351 | 18,159
Male tissues 351 | 17,142
Digestive Tract 350 | 17,369
Female tissues 350 | 17,400
Liver and Pancreas 349 | 16,750
Nervous System 349 | 16,725
Skin and soft tissues 349 | 17,230
Blood and immune system 347 | 16,909
Respiratory system 347 | 16,393
Cardiovascular System 340 | 15,192

Target Family

Non-IDG 240 | 12,091
Enzyme 43 | 4,145
Transporter 24 | 473
GPCR 23 | 408
Kinase 20 | 634
Ion Channel 7 | 344
Transcription Factor 2 | 1,400

CSPA Cell Line

LN18 359 | 359
U-251 MG 405 | 405
Glioblastoma 376 | 376
HEK 329 | 329
Melanoma NSph 305 | 305
U-2 OS 286 | 286
LN229 283 | 283
RD 277 | 277
T98G 276 | 276
Rh28 265 | 265
ZL55 MPM 262 | 262
HeLa 260 | 260
Adipocytes 259 | 259
B-ALL 255 | 255
MelanomaAdh 243 | 243
A431 242 | 242
U-87 MG 242 | 242
Ruch-2 240 | 240
IMR-32 231 | 231
SDM104 228 | 228
P493-6 227 | 227
SDM5 221 | 221
L428 218 | 218
PASMC 217 | 217
CD4+CD25-Tcells 213 | 213
SDM4 211 | 211
KMH2 194 | 194
HDLM-2 193 | 193
HCC4012 192 | 192
MedB1 189 | 189
Jurkat 188 | 188
NK cells 182 | 182
NB4 181 | 181
L540 179 | 179
HBL-1 171 | 171
U2932 171 | 171
CaLu3 167 | 167
Lymphoma 163 | 163
SU-DHL-6 160 | 160
LNT229 154 | 154
SU4 (SU-DHL-4) 154 | 154
HL-60 146 | 146
786-O 112 | 112
SDM34 86 | 86
RH4 67 | 67
Braintumor 66 | 66
hMSC 59 | 59

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Integrin alpha-2 ITGA2 Tbio Non-IDG -2.58423 335.9 895
Protein disulfide-isomerase TMX3 TMX3 Tbio Enzyme -0.72922 5.29 80
Protein phosphatase 1 regulatory subunit 29 ELFN2 Tdark Enzyme 0.06 0.68 51
Claudin-12 CLDN12 Tbio Non-IDG -1.03235 8.71 137
Protein tweety homolog 3 TTYH3 Tbio Ion Channel -0.17609 1.56 17
Interleukin-6 receptor subunit beta IL6ST Tclin Non-IDG -1.72489 55.4 555
EMILIN-1 EMILIN1 Tbio Non-IDG -1.54226 36.3 0
Integrin alpha-3 ITGA3 Tbio Non-IDG -2.08360 104.1 587
Roundabout homolog 1 ROBO1 Tbio Non-IDG -2.15518 129.8 261