Development Level

Tbio 169 | 11,651
Tchem 26 | 1,388
Tdark 19 | 6,593
Tclin 17 | 612

Collection

GPCR: IDG Consortium (Complete... 2 | 25
Ion Channel: IDG Consortium (T... 1 | 99
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 12 | 979
preweaning lethality, incomple... 12 | 499
abnormal behavior 9 | 298
decreased vertical activity 5 | 208
enlarged heart 5 | 210
abnormal retina morphology 4 | 71
decreased body weight 4 | 161
decreased total body fat amoun... 4 | 207
enlarged spleen 4 | 41
increased bone mineral content 4 | 108
increased circulating choleste... 4 | 66
increased lean body mass 4 | 172
abnormal seminal vesicle morph... 3 | 114
decreased body length 3 | 101
decreased circulating triglyce... 3 | 79
embryonic lethality prior to t... 3 | 278
hyperactivity 3 | 148
increased fasted circulating g... 3 | 76
increased heart weight 3 | 62
increased mean corpuscular vol... 3 | 92
increased total body fat amoun... 3 | 134
abnormal bone structure 2 | 187
abnormal coat appearance 2 | 31
abnormal eye morphology 2 | 68
abnormal gait 2 | 69
abnormal heart morphology 2 | 162
abnormal lens morphology 2 | 81
abnormal pericardium morpholog... 2 | 26
abnormal snout morphology 2 | 23
abnormal vibrissa morphology 2 | 25
cardiovascular system phenotyp... 2 | 36
cataract 2 | 92
decreased cardiac muscle contr... 2 | 11
decreased circulating glucose ... 2 | 126
decreased circulating glycerol... 2 | 16
decreased erythrocyte cell num... 2 | 62
decreased grip strength 2 | 116
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
decreased prepulse inhibition 2 | 82
decreased startle reflex 2 | 75
hydrometra 2 | 53
hypoactivity 2 | 132
increased circulating HDL chol... 2 | 80
increased circulating glycerol... 2 | 9
increased circulating iron lev... 2 | 30
increased erythrocyte cell num... 2 | 39
increased or absent threshold ... 2 | 101
male infertility 2 | 123
persistence of hyaloid vascula... 2 | 33
tremors 2 | 39
abnormal ear morphology 1 | 9
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal head morphology 1 | 10
abnormal liver morphology 1 | 17
abnormal response to new envir... 1 | 10
abnormal retinal vasculature m... 1 | 27
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal tail movements 1 | 12
absent vibrissae 1 | 12
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral density 1 | 126
decreased circulating calcium ... 1 | 36
decreased circulating creatini... 1 | 39
decreased circulating phosphat... 1 | 27
decreased eosinophil cell numb... 1 | 24
decreased exploration in new e... 1 | 11
decreased fasted circulating g... 1 | 65
decreased heart rate 1 | 18
decreased heart rate variabili... 1 | 13
decreased mean corpuscular hem... 1 | 31
decreased mean platelet volume 1 | 25
dilated heart left ventricle 1 | 11
edema 1 | 59
enlarged epididymis 1 | 31
enlarged lymph nodes 1 | 37
enlarged uterus 1 | 11
impaired glucose tolerance 1 | 75
increased aggression 1 | 4
increased body weight 1 | 25
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating creatini... 1 | 38
increased circulating triglyce... 1 | 42
increased exploration in new e... 1 | 8
increased hemoglobin content 1 | 45
increased mean platelet volume 1 | 45
increased startle reflex 1 | 112
increased vertical activity 1 | 24
limb grasping 1 | 41
polycystic kidney 1 | 15
premature death 1 | 5
prolonged PQ interval 1 | 5
small superior vagus ganglion 1 | 74
trunk curl 1 | 16
vertebral fusion 1 | 23

Disease

Carcinoma 180 | 11,493
ovarian cancer 145 | 8,520
glioblastoma 140 | 5,792
osteosarcoma 122 | 7,950
medulloblastoma, large-cell 119 | 6,241
ependymoma 117 | 4,679
atypical teratoid / rhabdoid tumor 112 | 5,112
psoriasis 103 | 6,694
lung cancer 95 | 4,740
malignant mesothelioma 87 | 3,232
Breast cancer 82 | 3,578
group 3 medulloblastoma 80 | 4,104
invasive ductal carcinoma 79 | 2,951
Astrocytoma, Pilocytic 78 | 3,081
Cancer 78 | 2,499
adult high grade glioma 74 | 3,801
oligodendroglioma 72 | 2,850
Kidney cancer 69 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 68 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 68 | 3,291
lung carcinoma 68 | 2,843
intraductal papillary-mucinous adenoma (IPMA) 62 | 2,955
non-small cell lung cancer 62 | 2,890
pancreatic cancer 62 | 2,398
lung adenocarcinoma 60 | 2,716
subependymal giant cell astrocytoma 59 | 2,287
primitive neuroectodermal tumor 58 | 3,035
astrocytic glioma 57 | 2,597
cystic fibrosis 47 | 1,696
interstitial cystitis 47 | 2,312
ulcerative colitis 47 | 1,819
diabetes mellitus 45 | 1,728
ductal carcinoma in situ 45 | 1,745
pituitary cancer 44 | 1,972
Pick disease 42 | 1,894
colon cancer 39 | 1,478
group 4 medulloblastoma 39 | 1,855
juvenile dermatomyositis 39 | 1,187
primary pancreatic ductal adenocarcinoma 39 | 1,109
breast carcinoma 37 | 1,638
pancreatic ductal adenocarcinoma liver metastasis 37 | 1,962
Alzheimer's disease 36 | 658
Autosomal recessive predisposition 33 | 1,442
pediatric high grade glioma 32 | 1,064
Duchenne muscular dystrophy 31 | 601
adrenocortical carcinoma 31 | 1,428
Schizophrenia 30 | 1,160
acute quadriplegic myopathy 30 | 1,158
astrocytoma 30 | 1,146
tuberculosis 30 | 2,010
dermatomyositis 28 | 966
gastric carcinoma 28 | 807
Rheumatoid arthritis 27 | 1,191
Multiple myeloma 25 | 1,332
Liver Cirrhosis, Experimental 23 | 769
cutaneous lupus erythematosus 23 | 1,057
esophageal adenocarcinoma 21 | 737
autosomal dominant Emery-Dreifuss muscular dystrophy 20 | 510
progressive supranuclear palsy 20 | 676
active Crohn's disease 19 | 922
Atopic dermatitis 17 | 952
Breast Neoplasms 17 | 445
Liver cancer 17 | 604
Multiple Sclerosis 17 | 540
nasopharyngeal carcinoma 17 | 1,058
Down syndrome 16 | 499
Endometriosis 16 | 540
Intellectual disability 16 | 1,016
Mammary Neoplasms 16 | 425
Vascular disease 16 | 319
aldosterone-producing adenoma 16 | 665
primary Sjogren syndrome 16 | 735
Melanoma 15 | 711
Prostatic Neoplasms 15 | 495
Waldenstrons macroglobulinemia 15 | 765
Hypertension 14 | 396
Muscle hypotonia 14 | 571
Neoplasm Invasiveness 14 | 161
active ulcerative colitis 14 | 764
acute myeloid leukemia 14 | 783
fibroadenoma 14 | 559
mucosa-associated lymphoid tissue lymphoma 14 | 484
non primary Sjogren syndrome sicca 14 | 891
Bipolar Disorder 13 | 666
Epilepsy 13 | 792
Hypertensive disease 13 | 292
Kidney disease 13 | 430
Neurodegenerative disease 13 | 414
Obesity 13 | 678
sonic hedgehog group medulloblastoma 13 | 467
Colorectal Neoplasms 12 | 243
Dull intelligence 12 | 645
Low intelligence 12 | 645
Mental Retardation 12 | 645
Mental deficiency 12 | 645
Poor school performance 12 | 645
spina bifida 12 | 1,074
Becker muscular dystrophy 11 | 191
Short stature 11 | 531
pancreatic carcinoma 11 | 562

Tissue

Endocrine System 227 | 18,159
Female tissues 227 | 17,400
Blood and immune system 226 | 16,909
Digestive Tract 226 | 17,369
Nervous System 226 | 16,725
Skin and soft tissues 226 | 17,230
Male tissues 225 | 17,142
Urinary Tract 225 | 16,678
Liver and Pancreas 224 | 16,750
Respiratory system 223 | 16,393
Cardiovascular System 219 | 15,192

Target Family

Non-IDG 164 | 12,091
Enzyme 26 | 4,145
Transporter 16 | 473
Kinase 10 | 634
GPCR 8 | 408
Ion Channel 6 | 344
Transcription Factor 1 | 1,400

CSPA Cell Line

IMR-32 231 | 231
U-251 MG 405 | 405
Glioblastoma 376 | 376
LN18 359 | 359
HEK 329 | 329
Melanoma NSph 305 | 305
U-2 OS 286 | 286
LN229 283 | 283
RD 277 | 277
T98G 276 | 276
Rh28 265 | 265
ZL55 MPM 262 | 262
HeLa 260 | 260
Adipocytes 259 | 259
B-ALL 255 | 255
MelanomaAdh 243 | 243
A431 242 | 242
U-87 MG 242 | 242
Ruch-2 240 | 240
SDM104 228 | 228
P493-6 227 | 227
SDM5 221 | 221
L428 218 | 218
PASMC 217 | 217
CD4+CD25-Tcells 213 | 213
SDM4 211 | 211
KMH2 194 | 194
HDLM-2 193 | 193
HCC4012 192 | 192
MedB1 189 | 189
Jurkat 188 | 188
NK cells 182 | 182
NB4 181 | 181
L540 179 | 179
HBL-1 171 | 171
U2932 171 | 171
CaLu3 167 | 167
Lymphoma 163 | 163
SU-DHL-6 160 | 160
LNT229 154 | 154
SU4 (SU-DHL-4) 154 | 154
HL-60 146 | 146
786-O 112 | 112
SDM34 86 | 86
RH4 67 | 67
Braintumor 66 | 66
hMSC 59 | 59

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Integrin alpha-2 ITGA2 Tbio Non-IDG -2.58423 335.9 895
Immunoglobulin superfamily member 1 IGSF1 Tbio Non-IDG -1.62840 43.8 149
Protein tweety homolog 3 TTYH3 Tbio Ion Channel -0.17609 1.56 17
Interleukin-6 receptor subunit beta IL6ST Tclin Non-IDG -1.72489 55.4 555
EMILIN-1 EMILIN1 Tbio Non-IDG -1.54226 36.3 0
Integrin alpha-3 ITGA3 Tbio Non-IDG -2.08360 104.1 587
CD166 antigen ALCAM Tbio Non-IDG -2.49297 326.4 492
Amphoterin-induced protein 1 AMIGO1 Tbio Non-IDG -1.74542 52.4 221
Leucyl-cystinyl aminopeptidase LNPEP Tchem Enzyme -2.57244 394.0 103