Development Level

Tbio 184 | 11,445
Tchem 35 | 1,598
Tclin 23 | 613
Tdark 18 | 6,588

Collection

GPCR: IDG Consortium (Targets) 3 | 126
GPCR: IDG Consortium (Complete... 2 | 25

IMPC Phenotype

preweaning lethality, complete... 13 | 979
abnormal behavior 10 | 298
enlarged heart 9 | 210
preweaning lethality, incomple... 9 | 499
decreased vertical activity 6 | 208
abnormal heart morphology 5 | 162
decreased total body fat amoun... 5 | 207
abnormal embryo size 4 | 220
abnormal eye morphology 4 | 68
abnormal limb bud morphology 4 | 17
abnormal seminal vesicle morph... 4 | 114
abnormal sleep behavior 4 | 70
embryonic lethality prior to t... 4 | 278
enlarged spleen 4 | 41
increased bone mineral content 4 | 108
increased circulating choleste... 4 | 66
abnormal bone structure 3 | 187
abnormal kidney morphology 3 | 65
decreased circulating glucose ... 3 | 126
decreased circulating triglyce... 3 | 79
decreased grip strength 3 | 116
improved glucose tolerance 3 | 79
increased lean body mass 3 | 172
increased mean corpuscular vol... 3 | 92
increased total body fat amoun... 3 | 134
pallor 3 | 34
abnormal bone mineralization 2 | 38
abnormal coat appearance 2 | 31
abnormal cornea morphology 2 | 31
abnormal ear morphology 2 | 9
abnormal gait 2 | 69
abnormal lens morphology 2 | 81
abnormal neural tube closure 2 | 46
abnormal pericardium morpholog... 2 | 26
abnormal spleen morphology 2 | 55
abnormal vocalization 2 | 21
cardiovascular system phenotyp... 2 | 36
cataract 2 | 92
decreased body length 2 | 101
decreased body weight 2 | 161
decreased cardiac muscle contr... 2 | 11
decreased eosinophil cell numb... 2 | 24
decreased erythrocyte cell num... 2 | 62
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
decreased prepulse inhibition 2 | 82
decreased startle reflex 2 | 75
embryonic growth retardation 2 | 106
hydrometra 2 | 53
hyperactivity 2 | 148
hypoactivity 2 | 132
impaired glucose tolerance 2 | 75
increased B cell number 2 | 9
increased circulating HDL chol... 2 | 80
increased circulating iron lev... 2 | 30
increased circulating triglyce... 2 | 42
increased erythrocyte cell num... 2 | 39
increased heart weight 2 | 62
increased leukocyte cell numbe... 2 | 47
pale yolk sac 2 | 25
polycystic kidney 2 | 15
small superior vagus ganglion 2 | 74
tremors 2 | 39
abnormal allantois morphology 1 | 8
abnormal behavioral response t... 1 | 66
abnormal chorioallantoic fusio... 1 | 8
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal embryo turning 1 | 31
abnormal left-right axis patte... 1 | 2
abnormal neural tube morpholog... 1 | 12
abnormal retina morphology 1 | 71
abnormal snout morphology 1 | 23
abnormal somite shape 1 | 5
abnormal startle reflex 1 | 15
abnormal tail bud morphology 1 | 8
abnormal tail movements 1 | 12
abnormal urinary bladder morph... 1 | 11
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
absent vibrissae 1 | 12
decreased T cell number 1 | 15
decreased circulating phosphat... 1 | 27
decreased exploration in new e... 1 | 11
decreased mean corpuscular hem... 1 | 31
decreased mean platelet volume 1 | 25
decreased total retina thickne... 1 | 17
dilated heart left ventricle 1 | 11
edema 1 | 59
enlarged epididymis 1 | 31
enlarged lymph nodes 1 | 37
enlarged uterus 1 | 11
impaired pupillary reflex 1 | 26
increased aggression 1 | 4
increased bone mineral density 1 | 72
increased circulating creatini... 1 | 38
increased circulating glycerol... 1 | 9
persistence of hyaloid vascula... 1 | 33
syndactyly 1 | 23
vertebral fusion 1 | 23

Disease

Carcinoma 189 | 11,493
ovarian cancer 181 | 8,520
glioblastoma 140 | 5,792
osteosarcoma 140 | 7,950
psoriasis 127 | 6,694
medulloblastoma, large-cell 115 | 6,241
lung cancer 112 | 4,740
atypical teratoid / rhabdoid tumor 107 | 5,112
malignant mesothelioma 102 | 3,232
Cancer 101 | 2,499
ependymoma 100 | 4,679
lung carcinoma 96 | 2,843
Breast cancer 93 | 3,578
Astrocytoma, Pilocytic 90 | 3,081
non-small cell lung cancer 89 | 2,890
intraductal papillary-mucinous adenoma (IPMA) 88 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 86 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 86 | 3,291
invasive ductal carcinoma 86 | 2,951
pancreatic cancer 86 | 2,398
group 3 medulloblastoma 78 | 4,104
lung adenocarcinoma 78 | 2,716
adult high grade glioma 74 | 3,801
ulcerative colitis 72 | 1,819
Kidney cancer 64 | 2,613
interstitial cystitis 64 | 2,312
ductal carcinoma in situ 60 | 1,745
subependymal giant cell astrocytoma 59 | 2,287
cystic fibrosis 58 | 1,696
pancreatic ductal adenocarcinoma liver metastasis 58 | 1,962
oligodendroglioma 56 | 2,850
tuberculosis 52 | 2,010
primitive neuroectodermal tumor 50 | 3,035
breast carcinoma 49 | 1,638
group 4 medulloblastoma 49 | 1,855
juvenile dermatomyositis 48 | 1,187
astrocytic glioma 47 | 2,597
diabetes mellitus 47 | 1,728
primary pancreatic ductal adenocarcinoma 47 | 1,109
pituitary cancer 45 | 1,972
gastric carcinoma 40 | 807
Autosomal recessive predisposition 39 | 1,442
acute quadriplegic myopathy 39 | 1,158
dermatomyositis 39 | 966
Duchenne muscular dystrophy 38 | 601
cutaneous lupus erythematosus 36 | 1,057
esophageal adenocarcinoma 36 | 737
Pick disease 35 | 1,894
colon cancer 35 | 1,478
astrocytoma 34 | 1,146
Multiple myeloma 33 | 1,332
Liver Cirrhosis, Experimental 32 | 769
adrenocortical carcinoma 32 | 1,428
spina bifida 32 | 1,074
autosomal dominant Emery-Dreifuss muscular dystrophy 31 | 510
pediatric high grade glioma 30 | 1,064
Rheumatoid arthritis 29 | 1,191
Schizophrenia 29 | 1,160
nasopharyngeal carcinoma 26 | 1,058
Atopic dermatitis 25 | 952
Alzheimer's disease 24 | 658
Down syndrome 24 | 499
Breast Neoplasms 23 | 445
Mammary Neoplasms 23 | 425
fibroadenoma 23 | 559
Multiple Sclerosis 22 | 540
active Crohn's disease 22 | 922
mucosa-associated lymphoid tissue lymphoma 22 | 484
Liver cancer 21 | 604
Vascular disease 21 | 319
aldosterone-producing adenoma 21 | 665
Intellectual disability 20 | 1,016
Endometriosis 18 | 540
Hypersensitivity reaction type II disease 18 | 253
Kidney disease 18 | 430
Melanoma 18 | 711
Waldenstrons macroglobulinemia 18 | 765
active ulcerative colitis 18 | 764
primary Sjogren syndrome 18 | 735
Prostatic Neoplasms 17 | 495
Atherosclerosis 16 | 291
Dull intelligence 16 | 645
Low intelligence 16 | 645
Mental Retardation 16 | 645
Mental deficiency 16 | 645
Poor school performance 16 | 645
posterior fossa group A ependymoma 16 | 468
Arthritis 15 | 290
Cognitive delay 15 | 608
Coronary artery disease 15 | 268
Global developmental delay 15 | 608
Mental and motor retardation 15 | 608
acute myeloid leukemia 15 | 783
Epilepsy 14 | 792
Hypertension 14 | 396
Seizures 14 | 596
Short stature 14 | 531
non primary Sjogren syndrome sicca 14 | 891
pancreatic carcinoma 14 | 562
sonic hedgehog group medulloblastoma 14 | 467

Tissue

Endocrine System 255 | 18,159
Female tissues 255 | 17,400
Respiratory system 255 | 16,393
Digestive Tract 254 | 17,369
Blood and immune system 253 | 16,909
Skin and soft tissues 253 | 17,230
Urinary Tract 253 | 16,678
Liver and Pancreas 252 | 16,750
Male tissues 252 | 17,142
Nervous System 252 | 16,725
Cardiovascular System 249 | 15,192

Target Family

Non-IDG 179 | 12,091
Enzyme 34 | 4,145
Kinase 16 | 634
Transporter 15 | 473
GPCR 11 | 408
Ion Channel 4 | 344
Transcription Factor 1 | 1,400

CSPA Cell Line

HeLa 260 | 260
U-251 MG 405 | 405
Glioblastoma 376 | 376
LN18 359 | 359
HEK 329 | 329
Melanoma NSph 305 | 305
U-2 OS 286 | 286
LN229 283 | 283
RD 277 | 277
T98G 276 | 276
Rh28 265 | 265
ZL55 MPM 262 | 262
Adipocytes 259 | 259
B-ALL 255 | 255
MelanomaAdh 243 | 243
A431 242 | 242
U-87 MG 242 | 242
Ruch-2 240 | 240
IMR-32 231 | 231
SDM104 228 | 228
P493-6 227 | 227
SDM5 221 | 221
L428 218 | 218
PASMC 217 | 217
CD4+CD25-Tcells 213 | 213
SDM4 211 | 211
KMH2 194 | 194
HDLM-2 193 | 193
HCC4012 192 | 192
MedB1 189 | 189
Jurkat 188 | 188
NK cells 182 | 182
NB4 181 | 181
L540 179 | 179
HBL-1 171 | 171
U2932 171 | 171
CaLu3 167 | 167
Lymphoma 163 | 163
SU-DHL-6 160 | 160
LNT229 154 | 154
SU4 (SU-DHL-4) 154 | 154
HL-60 146 | 146
786-O 112 | 112
SDM34 86 | 86
RH4 67 | 67
Braintumor 66 | 66
hMSC 59 | 59

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Adhesion G-protein coupled receptor G1 ADGRG1 Tbio GPCR -1.94601 100.6 182
Neuroplastin NPTN Tbio Non-IDG -2.31075 211.6 201
CD109 antigen CD109 Tbio Non-IDG -1.85817 77.8 239
Mucin-16 MUC16 Tbio Non-IDG -2.09951 138.4 0
Protein HEG homolog 1 HEG1 Tbio Non-IDG -2.11308 129.3 11
Cadherin-10 CDH10 Tbio Non-IDG -0.86821 9.34 155
Sodium bicarbonate cotransporter 3 SLC4A7 Tbio Transporter -1.82039 64.7 133
G-protein coupled receptor 39 GPR39 Tchem GPCR -1.77076 66.5 232
VPS10 domain-containing receptor SorCS2 SORCS2 Tbio Non-IDG -0.79588 6.26 56