Development Level

Tbio 227 | 11,651
Tchem 40 | 1,388
Tclin 32 | 612
Tdark 30 | 6,593

Collection

RFA-RM-18-021 4 | 328
GPCR: IDG Consortium (Complete... 3 | 25
GPCR: IDG Consortium (Targets) 2 | 126
Ion Channel: IDG Consortium (T... 2 | 99

IMPC Phenotype

preweaning lethality, incomple... 20 | 499
preweaning lethality, complete... 13 | 979
abnormal behavior 10 | 298
enlarged heart 8 | 210
abnormal embryo size 7 | 220
decreased vertical activity 7 | 208
embryonic lethality prior to t... 7 | 278
impaired glucose tolerance 6 | 75
increased bone mineral content 5 | 108
abnormal bone structure 4 | 187
abnormal eye morphology 4 | 68
abnormal heart morphology 4 | 162
abnormal seminal vesicle morph... 4 | 114
decreased body weight 4 | 161
decreased circulating glucose ... 4 | 126
decreased grip strength 4 | 116
decreased startle reflex 4 | 75
decreased total body fat amoun... 4 | 207
embryonic growth retardation 4 | 106
enlarged spleen 4 | 41
improved glucose tolerance 4 | 79
increased circulating choleste... 4 | 66
increased heart weight 4 | 62
increased total body fat amoun... 4 | 134
pallor 4 | 34
abnormal coat appearance 3 | 31
abnormal gait 3 | 69
abnormal kidney morphology 3 | 65
abnormal limb bud morphology 3 | 17
abnormal pericardium morpholog... 3 | 26
abnormal sleep behavior 3 | 70
decreased body length 3 | 101
decreased bone mineral density 3 | 126
decreased erythrocyte cell num... 3 | 62
decreased lean body mass 3 | 135
decreased leukocyte cell numbe... 3 | 73
hyperactivity 3 | 148
hypoactivity 3 | 132
increased circulating triglyce... 3 | 42
increased hematocrit 3 | 46
increased lean body mass 3 | 172
increased leukocyte cell numbe... 3 | 47
increased mean corpuscular vol... 3 | 92
pale yolk sac 3 | 25
tremors 3 | 39
abnormal coat-hair pigmentatio... 2 | 64
abnormal ear morphology 2 | 9
abnormal embryo turning 2 | 31
abnormal limb position 2 | 3
abnormal skin morphology 2 | 50
abnormal spleen morphology 2 | 55
cardiovascular system phenotyp... 2 | 36
decreased bone mineral content 2 | 151
decreased cardiac muscle contr... 2 | 11
decreased circulating creatini... 2 | 39
decreased circulating triglyce... 2 | 79
decreased eosinophil cell numb... 2 | 24
decreased fasted circulating g... 2 | 65
decreased heart rate 2 | 18
decreased prepulse inhibition 2 | 82
embryonic lethality prior to o... 2 | 239
hydrometra 2 | 53
impaired righting response 2 | 26
increased circulating HDL chol... 2 | 80
increased circulating alkaline... 2 | 122
increased circulating iron lev... 2 | 30
increased erythrocyte cell num... 2 | 39
increased fasted circulating g... 2 | 76
increased hemoglobin content 2 | 45
increased lymphocyte cell numb... 2 | 32
increased mean platelet volume 2 | 45
increased monocyte cell number 2 | 63
increased vertical activity 2 | 24
male infertility 2 | 123
prolonged ST segment 2 | 36
thrombocytopenia 2 | 56
trunk curl 2 | 16
abnormal behavioral response t... 1 | 66
abnormal craniofacial morpholo... 1 | 33
abnormal lens morphology 1 | 81
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal startle reflex 1 | 15
abnormal tail movements 1 | 12
decreased T cell number 1 | 15
decreased circulating chloride... 1 | 30
decreased exploration in new e... 1 | 11
decreased mean corpuscular hem... 1 | 31
enlarged lymph nodes 1 | 37
enlarged uterus 1 | 11
increased aggression 1 | 4
increased bone mineral density 1 | 72
increased circulating alanine ... 1 | 13
increased circulating creatini... 1 | 38
increased eosinophil cell numb... 1 | 11
increased exploration in new e... 1 | 8
limb grasping 1 | 41
long tibia 1 | 25
small superior vagus ganglion 1 | 74
vertebral fusion 1 | 23

Disease

Carcinoma 256 | 11,493
ovarian cancer 216 | 8,520
glioblastoma 189 | 5,792
osteosarcoma 184 | 7,950
medulloblastoma, large-cell 160 | 6,241
atypical teratoid / rhabdoid tumor 150 | 5,112
psoriasis 143 | 6,694
ependymoma 135 | 4,679
lung cancer 135 | 4,740
Breast cancer 124 | 3,578
malignant mesothelioma 119 | 3,232
Cancer 115 | 2,499
lung carcinoma 115 | 2,843
group 3 medulloblastoma 109 | 4,104
Astrocytoma, Pilocytic 108 | 3,081
invasive ductal carcinoma 107 | 2,951
adult high grade glioma 100 | 3,801
non-small cell lung cancer 100 | 2,890
Kidney cancer 99 | 2,613
intraductal papillary-mucinous neoplasm (IPMN) 96 | 3,291
lung adenocarcinoma 94 | 2,716
pancreatic cancer 94 | 2,398
intraductal papillary-mucinous adenoma (IPMA) 88 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 88 | 2,989
oligodendroglioma 88 | 2,850
interstitial cystitis 77 | 2,312
primitive neuroectodermal tumor 74 | 3,035
ulcerative colitis 73 | 1,819
subependymal giant cell astrocytoma 72 | 2,287
astrocytic glioma 70 | 2,597
pituitary cancer 66 | 1,972
cystic fibrosis 64 | 1,696
breast carcinoma 63 | 1,638
ductal carcinoma in situ 62 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 58 | 1,962
primary pancreatic ductal adenocarcinoma 58 | 1,109
diabetes mellitus 54 | 1,728
group 4 medulloblastoma 54 | 1,855
colon cancer 51 | 1,478
Pick disease 50 | 1,894
tuberculosis 50 | 2,010
adrenocortical carcinoma 49 | 1,428
juvenile dermatomyositis 49 | 1,187
Autosomal recessive predisposition 48 | 1,442
pediatric high grade glioma 45 | 1,064
astrocytoma 44 | 1,146
Schizophrenia 43 | 1,160
gastric carcinoma 41 | 807
acute quadriplegic myopathy 38 | 1,158
cutaneous lupus erythematosus 37 | 1,057
dermatomyositis 37 | 966
Multiple myeloma 36 | 1,332
Duchenne muscular dystrophy 34 | 601
active Crohn's disease 34 | 922
esophageal adenocarcinoma 34 | 737
Multiple Sclerosis 33 | 540
Rheumatoid arthritis 32 | 1,191
Alzheimer's disease 31 | 658
Breast Neoplasms 30 | 445
autosomal dominant Emery-Dreifuss muscular dystrophy 30 | 510
Mammary Neoplasms 29 | 425
Atopic dermatitis 28 | 952
Liver cancer 28 | 604
nasopharyngeal carcinoma 28 | 1,058
Intellectual disability 27 | 1,016
acute myeloid leukemia 26 | 783
spina bifida 26 | 1,074
Down syndrome 25 | 499
active ulcerative colitis 25 | 764
fibroadenoma 25 | 559
aldosterone-producing adenoma 24 | 665
Dull intelligence 23 | 645
Liver Cirrhosis, Experimental 23 | 769
Low intelligence 23 | 645
Mental Retardation 23 | 645
Mental deficiency 23 | 645
Poor school performance 23 | 645
primary Sjogren syndrome 23 | 735
Kidney disease 21 | 430
Bipolar Disorder 20 | 666
Epilepsy 20 | 792
Obesity 20 | 678
posterior fossa group A ependymoma 20 | 468
Hypersensitivity reaction type II disease 19 | 253
Melanoma 19 | 711
Orbital separation excessive 19 | 244
Stomach Neoplasms 19 | 300
mucosa-associated lymphoid tissue lymphoma 19 | 484
Cognitive delay 18 | 608
Endometriosis 18 | 540
Global developmental delay 18 | 608
Mental and motor retardation 18 | 608
Prostatic Neoplasms 18 | 495
medulloblastoma 18 | 720
Short stature 17 | 531
Vascular disease 17 | 319
pancreatic carcinoma 17 | 562
progressive supranuclear palsy 17 | 676
Asthma 16 | 385
non primary Sjogren syndrome sicca 16 | 891

Tissue

Endocrine System 326 | 18,159
Female tissues 326 | 17,400
Blood and immune system 325 | 16,909
Male tissues 325 | 17,142
Respiratory system 325 | 16,393
Skin and soft tissues 325 | 17,230
Urinary Tract 325 | 16,678
Digestive Tract 324 | 17,369
Liver and Pancreas 324 | 16,750
Nervous System 324 | 16,725
Cardiovascular System 319 | 15,192

Target Family

Non-IDG 221 | 12,091
Enzyme 41 | 4,145
Kinase 21 | 634
Transporter 21 | 473
GPCR 16 | 408
Ion Channel 9 | 344

CSPA Cell Line

HEK 329 | 329
U-251 MG 405 | 405
Glioblastoma 376 | 376
LN18 359 | 359
Melanoma NSph 305 | 305
U-2 OS 286 | 286
LN229 283 | 283
RD 277 | 277
T98G 276 | 276
Rh28 265 | 265
ZL55 MPM 262 | 262
HeLa 260 | 260
Adipocytes 259 | 259
B-ALL 255 | 255
MelanomaAdh 243 | 243
A431 242 | 242
U-87 MG 242 | 242
Ruch-2 240 | 240
IMR-32 231 | 231
SDM104 228 | 228
P493-6 227 | 227
SDM5 221 | 221
L428 218 | 218
PASMC 217 | 217
CD4+CD25-Tcells 213 | 213
SDM4 211 | 211
KMH2 194 | 194
HDLM-2 193 | 193
HCC4012 192 | 192
MedB1 189 | 189
Jurkat 188 | 188
NK cells 182 | 182
NB4 181 | 181
L540 179 | 179
HBL-1 171 | 171
U2932 171 | 171
CaLu3 167 | 167
Lymphoma 163 | 163
SU-DHL-6 160 | 160
LNT229 154 | 154
SU4 (SU-DHL-4) 154 | 154
HL-60 146 | 146
786-O 112 | 112
SDM34 86 | 86
RH4 67 | 67
Braintumor 66 | 66
hMSC 59 | 59

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Integrin alpha-2 ITGA2 Tbio Non-IDG -2.58423 335.9 895
Protein disulfide-isomerase TMX3 TMX3 Tbio Enzyme -0.72922 5.29 80
Cysteine-rich with EGF-like domain protein 2 CRELD2 Tbio Non-IDG -0.79330 8.01 176
Protein tweety homolog 3 TTYH3 Tbio Ion Channel -0.17609 1.56 17
Desmocollin-2 DSC2 Tbio Non-IDG -1.89689 79.7 173
Interleukin-6 receptor subunit beta IL6ST Tclin Non-IDG -1.72489 55.4 555
Integrin alpha-9 ITGA9 Tbio Non-IDG -1.46619 29.0 124
Integrin alpha-3 ITGA3 Tbio Non-IDG -2.08360 104.1 587
Roundabout homolog 1 ROBO1 Tbio Non-IDG -2.15518 129.8 261