Development Level

Tbio 248 | 11,445
Tchem 62 | 1,598
Tclin 34 | 613
Tdark 32 | 6,588

Collection

GPCR: IDG Consortium (Complete... 4 | 25
Ion Channel: IDG Consortium (T... 3 | 99
GPCR: IDG Consortium (Targets) 2 | 126

IMPC Phenotype

preweaning lethality, incomple... 16 | 499
preweaning lethality, complete... 14 | 979
abnormal behavior 13 | 298
decreased total body fat amoun... 9 | 207
decreased vertical activity 8 | 208
abnormal embryo size 6 | 220
embryonic lethality prior to t... 6 | 278
enlarged heart 6 | 210
increased heart weight 6 | 62
abnormal sleep behavior 5 | 70
decreased body length 5 | 101
decreased grip strength 5 | 116
increased lean body mass 5 | 172
abnormal bone structure 4 | 187
abnormal eye morphology 4 | 68
abnormal seminal vesicle morph... 4 | 114
decreased body weight 4 | 161
decreased circulating choleste... 4 | 93
decreased circulating glucose ... 4 | 126
decreased circulating triglyce... 4 | 79
improved glucose tolerance 4 | 79
increased bone mineral content 4 | 108
increased total body fat amoun... 4 | 134
abnormal behavioral response t... 3 | 66
abnormal coat appearance 3 | 31
abnormal limb bud morphology 3 | 17
decreased bone mineral content 3 | 151
decreased lean body mass 3 | 135
decreased prepulse inhibition 3 | 82
decreased startle reflex 3 | 75
embryonic growth retardation 3 | 106
embryonic lethality prior to o... 3 | 239
enlarged spleen 3 | 41
hyperactivity 3 | 148
increased circulating choleste... 3 | 66
increased erythrocyte cell num... 3 | 39
increased leukocyte cell numbe... 3 | 47
increased mean corpuscular vol... 3 | 92
short tibia 3 | 97
abnormal coat-hair pigmentatio... 2 | 64
abnormal cranium morphology 2 | 36
abnormal femur morphology 2 | 14
abnormal snout morphology 2 | 23
abnormal urinary bladder morph... 2 | 11
cardiovascular system phenotyp... 2 | 36
decreased cardiac muscle contr... 2 | 11
decreased circulating HDL chol... 2 | 68
decreased circulating iron lev... 2 | 32
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular hem... 2 | 31
dilated heart left ventricle 2 | 11
enlarged uterus 2 | 11
impaired glucose tolerance 2 | 75
increased bone mineral density 2 | 72
increased circulating triglyce... 2 | 42
increased fasted circulating g... 2 | 76
increased hematocrit 2 | 46
increased hemoglobin content 2 | 45
increased mean corpuscular hem... 2 | 96
increased vertical activity 2 | 24
male infertility 2 | 123
pale yolk sac 2 | 25
pallor 2 | 34
polycystic kidney 2 | 15
prolonged ST segment 2 | 36
tremors 2 | 39
abnormal craniofacial morpholo... 1 | 33
abnormal ear morphology 1 | 9
abnormal lens morphology 1 | 81
abnormal locomotor activation 1 | 16
abnormal neural tube closure 1 | 46
abnormal retina morphology 1 | 71
abnormal startle reflex 1 | 15
abnormal tail movements 1 | 12
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 18
abnormal vocalization 1 | 21
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased circulating bilirubi... 1 | 19
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased exploration in new e... 1 | 11
decreased neutrophil cell numb... 1 | 42
decreased total retina thickne... 1 | 17
enlarged lymph nodes 1 | 37
hydrometra 1 | 53
impaired pupillary reflex 1 | 26
impaired righting response 1 | 26
increased aggression 1 | 4
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased circulating HDL chol... 1 | 80
increased circulating iron lev... 1 | 30
increased eosinophil cell numb... 1 | 11
increased exploration in new e... 1 | 8
increased red blood cell distr... 1 | 34
small superior vagus ganglion 1 | 74
trunk curl 1 | 16
vertebral fusion 1 | 23

Disease

Carcinoma 302 | 11,493
ovarian cancer 244 | 8,520
glioblastoma 209 | 5,792
osteosarcoma 196 | 7,950
medulloblastoma, large-cell 181 | 6,241
psoriasis 178 | 6,694
atypical teratoid / rhabdoid tumor 170 | 5,112
ependymoma 167 | 4,679
lung cancer 167 | 4,740
Breast cancer 149 | 3,578
malignant mesothelioma 149 | 3,232
invasive ductal carcinoma 147 | 2,951
lung carcinoma 143 | 2,843
Cancer 142 | 2,499
Astrocytoma, Pilocytic 137 | 3,081
pancreatic cancer 135 | 2,398
non-small cell lung cancer 130 | 2,890
adult high grade glioma 126 | 3,801
intraductal papillary-mucinous adenoma (IPMA) 126 | 2,955
Kidney cancer 122 | 2,613
lung adenocarcinoma 118 | 2,716
intraductal papillary-mucinous neoplasm (IPMN) 117 | 3,291
intraductal papillary-mucinous carcinoma (IPMC) 115 | 2,989
group 3 medulloblastoma 111 | 4,104
interstitial cystitis 110 | 2,312
oligodendroglioma 108 | 2,850
cystic fibrosis 104 | 1,696
ulcerative colitis 101 | 1,819
ductal carcinoma in situ 96 | 1,745
breast carcinoma 88 | 1,638
astrocytic glioma 85 | 2,597
primary pancreatic ductal adenocarcinoma 85 | 1,109
primitive neuroectodermal tumor 85 | 3,035
subependymal giant cell astrocytoma 80 | 2,287
tuberculosis 75 | 2,010
colon cancer 74 | 1,478
pituitary cancer 71 | 1,972
diabetes mellitus 66 | 1,728
gastric carcinoma 66 | 807
group 4 medulloblastoma 66 | 1,855
Duchenne muscular dystrophy 63 | 601
juvenile dermatomyositis 63 | 1,187
adrenocortical carcinoma 62 | 1,428
pancreatic ductal adenocarcinoma liver metastasis 61 | 1,962
Pick disease 51 | 1,894
astrocytoma 51 | 1,146
autosomal dominant Emery-Dreifuss muscular dystrophy 50 | 510
Schizophrenia 48 | 1,160
Liver Cirrhosis, Experimental 47 | 769
pediatric high grade glioma 47 | 1,064
esophageal adenocarcinoma 46 | 737
Autosomal recessive predisposition 45 | 1,442
Atopic dermatitis 44 | 952
acute quadriplegic myopathy 44 | 1,158
cutaneous lupus erythematosus 41 | 1,057
dermatomyositis 41 | 966
nasopharyngeal carcinoma 41 | 1,058
Rheumatoid arthritis 40 | 1,191
active Crohn's disease 37 | 922
fibroadenoma 37 | 559
Liver cancer 36 | 604
Alzheimer's disease 35 | 658
primary Sjogren syndrome 32 | 735
Down syndrome 31 | 499
Multiple Sclerosis 31 | 540
Melanoma 30 | 711
Atherosclerosis 29 | 291
Breast Neoplasms 29 | 445
active ulcerative colitis 29 | 764
Endometriosis 28 | 540
Kidney disease 28 | 430
Mammary Neoplasms 28 | 425
aldosterone-producing adenoma 28 | 665
interstitial lung disease 28 | 298
Skin cancer 27 | 469
Hypertension 25 | 396
Multiple myeloma 25 | 1,332
Coronary artery disease 24 | 268
Hypersensitivity reaction type II disease 24 | 253
limb girdle muscular dystrophy 2A 24 | 213
mucosa-associated lymphoid tissue lymphoma 24 | 484
sonic hedgehog group medulloblastoma 24 | 467
spina bifida 24 | 1,074
Becker muscular dystrophy 23 | 191
Anemia 22 | 365
Asthma 22 | 385
head and neck cancer 22 | 271
posterior fossa group A ependymoma 22 | 468
Bipolar Disorder 21 | 666
Colorectal Neoplasms 21 | 243
Liver disease 21 | 237
Obesity 21 | 678
acute myeloid leukemia 21 | 783
medulloblastoma 21 | 720
sarcoidosis 21 | 370
Heart disease 20 | 306
Intellectual disability 20 | 1,016
Prostatic Neoplasms 20 | 495
nephrosclerosis 20 | 333
urothelial carcinoma 20 | 318

Tissue

Endocrine System 364 | 18,159
Female tissues 364 | 17,400
Blood and immune system 363 | 16,909
Digestive Tract 363 | 17,369
Male tissues 363 | 17,142
Nervous System 363 | 16,725
Skin and soft tissues 363 | 17,230
Respiratory system 362 | 16,393
Liver and Pancreas 361 | 16,750
Urinary Tract 360 | 16,678
Cardiovascular System 354 | 15,192

Target Family

Non-IDG 261 | 12,091
Enzyme 42 | 4,145
Kinase 25 | 634
GPCR 21 | 408
Transporter 20 | 473
Ion Channel 7 | 344

CSPA Cell Line

Glioblastoma 376 | 376
U-251 MG 405 | 405
LN18 359 | 359
HEK 329 | 329
Melanoma NSph 305 | 305
U-2 OS 286 | 286
LN229 283 | 283
RD 277 | 277
T98G 276 | 276
Rh28 265 | 265
ZL55 MPM 262 | 262
HeLa 260 | 260
Adipocytes 259 | 259
B-ALL 255 | 255
MelanomaAdh 243 | 243
A431 242 | 242
U-87 MG 242 | 242
Ruch-2 240 | 240
IMR-32 231 | 231
SDM104 228 | 228
P493-6 227 | 227
SDM5 221 | 221
L428 218 | 218
PASMC 217 | 217
CD4+CD25-Tcells 213 | 213
SDM4 211 | 211
KMH2 194 | 194
HDLM-2 193 | 193
HCC4012 192 | 192
MedB1 189 | 189
Jurkat 188 | 188
NK cells 182 | 182
NB4 181 | 181
L540 179 | 179
HBL-1 171 | 171
U2932 171 | 171
CaLu3 167 | 167
Lymphoma 163 | 163
SU-DHL-6 160 | 160
LNT229 154 | 154
SU4 (SU-DHL-4) 154 | 154
HL-60 146 | 146
786-O 112 | 112
SDM34 86 | 86
RH4 67 | 67
Braintumor 66 | 66
hMSC 59 | 59

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Protein FAM171A2 FAM171A2 Tdark Non-IDG 0.00000 20
Adhesion G-protein coupled receptor G1 ADGRG1 Tbio GPCR -1.94601 100.6 182
Neuroplastin NPTN Tbio Non-IDG -2.31075 211.6 201
CD109 antigen CD109 Tbio Non-IDG -1.85817 77.8 239
Protein HEG homolog 1 HEG1 Tbio Non-IDG -2.11308 129.3 11
Integrin alpha-11 ITGA11 Tbio Non-IDG -1.13736 14.3 76
Sodium bicarbonate cotransporter 3 SLC4A7 Tbio Transporter -1.82039 64.7 133
Endoglin ENG Tbio Non-IDG -3.10482 1235.9 1622
G-protein coupled receptor 39 GPR39 Tchem GPCR -1.77076 66.5 232