Development Level

Tbio 171 | 11,445
Tclin 37 | 613
Tchem 36 | 1,598
Tdark 11 | 6,588

Collection

GPCR: IDG Consortium (Complete... 3 | 25
GPCR: IDG Consortium (Targets) 1 | 126
Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

preweaning lethality, incomple... 11 | 499
preweaning lethality, complete... 9 | 979
abnormal behavior 7 | 298
embryonic lethality prior to t... 6 | 278
decreased total body fat amoun... 5 | 207
decreased vertical activity 5 | 208
enlarged heart 5 | 210
abnormal embryo size 4 | 220
abnormal seminal vesicle morph... 3 | 114
embryonic growth retardation 3 | 106
enlarged spleen 3 | 41
improved glucose tolerance 3 | 79
increased bone mineral content 3 | 108
increased heart weight 3 | 62
increased mean corpuscular vol... 3 | 92
abnormal eye morphology 2 | 68
abnormal gait 2 | 69
abnormal heart morphology 2 | 162
abnormal limb bud morphology 2 | 17
abnormal pericardium morpholog... 2 | 26
abnormal sleep behavior 2 | 70
abnormal vibrissa morphology 2 | 25
cardiovascular system phenotyp... 2 | 36
decreased body length 2 | 101
decreased cardiac muscle contr... 2 | 11
decreased circulating glucose ... 2 | 126
decreased grip strength 2 | 116
decreased lean body mass 2 | 135
decreased startle reflex 2 | 75
hyperactivity 2 | 148
impaired glucose tolerance 2 | 75
increased circulating choleste... 2 | 66
increased circulating sodium l... 2 | 71
increased circulating triglyce... 2 | 42
increased erythrocyte cell num... 2 | 39
increased lean body mass 2 | 172
increased spleen weight 2 | 10
increased total body fat amoun... 2 | 134
pallor 2 | 34
tremors 2 | 39
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal coat appearance 1 | 31
abnormal cornea morphology 1 | 31
abnormal ear morphology 1 | 9
abnormal embryo development 1 | 7
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal liver morphology 1 | 17
abnormal locomotor activation 1 | 16
abnormal placenta size 1 | 20
abnormal response to new envir... 1 | 10
abnormal retina morphology 1 | 71
abnormal snout morphology 1 | 23
abnormal tail movements 1 | 12
abnormal urinary bladder morph... 1 | 11
abnormal vocalization 1 | 21
absent startle reflex 1 | 24
absent vibrissae 1 | 12
decreased circulating calcium ... 1 | 36
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased exploration in new e... 1 | 11
decreased heart rate 1 | 18
decreased heart rate variabili... 1 | 13
decreased mean corpuscular hem... 1 | 31
decreased prepulse inhibition 1 | 82
dilated heart left ventricle 1 | 11
embryonic lethality prior to o... 1 | 239
enlarged epididymis 1 | 31
enlarged lymph nodes 1 | 37
hydrometra 1 | 53
hypoactivity 1 | 132
impaired pupillary reflex 1 | 26
increased body length 1 | 32
increased body weight 1 | 25
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating glycerol... 1 | 9
increased circulating iron lev... 1 | 30
increased circulating thyroxin... 1 | 7
increased exploration in new e... 1 | 8
increased fasted circulating g... 1 | 76
increased heart rate variabili... 1 | 7
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
increased vertical activity 1 | 24
limb grasping 1 | 41
male infertility 1 | 123
pale yolk sac 1 | 25
prenatal lethality prior to he... 1 | 87
prolonged PQ interval 1 | 5
prolonged QT interval 1 | 38
small superior vagus ganglion 1 | 74
vertebral fusion 1 | 23

Disease

Carcinoma 197 | 11,493
osteosarcoma 151 | 7,950
ovarian cancer 150 | 8,520
glioblastoma 137 | 5,792
Cancer 119 | 2,499
psoriasis 115 | 6,694
lung cancer 113 | 4,740
lung carcinoma 107 | 2,843
medulloblastoma, large-cell 100 | 6,241
non-small cell lung cancer 88 | 2,890
interstitial cystitis 87 | 2,312
malignant mesothelioma 87 | 3,232
Astrocytoma, Pilocytic 86 | 3,081
atypical teratoid / rhabdoid tumor 86 | 5,112
invasive ductal carcinoma 84 | 2,951
Breast cancer 80 | 3,578
ependymoma 80 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 78 | 3,291
adult high grade glioma 74 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 73 | 2,989
pancreatic cancer 71 | 2,398
lung adenocarcinoma 70 | 2,716
intraductal papillary-mucinous adenoma (IPMA) 67 | 2,955
tuberculosis 66 | 2,010
ulcerative colitis 63 | 1,819
Kidney cancer 58 | 2,613
subependymal giant cell astrocytoma 58 | 2,287
group 3 medulloblastoma 56 | 4,104
diabetes mellitus 55 | 1,728
oligodendroglioma 54 | 2,850
cutaneous lupus erythematosus 48 | 1,057
cystic fibrosis 44 | 1,696
breast carcinoma 43 | 1,638
ductal carcinoma in situ 43 | 1,745
Multiple Sclerosis 41 | 540
Rheumatoid arthritis 41 | 1,191
dermatomyositis 41 | 966
juvenile dermatomyositis 41 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 41 | 1,962
primitive neuroectodermal tumor 39 | 3,035
Hypersensitivity reaction type II disease 38 | 253
astrocytic glioma 38 | 2,597
Schizophrenia 37 | 1,160
primary pancreatic ductal adenocarcinoma 37 | 1,109
Autosomal recessive predisposition 36 | 1,442
group 4 medulloblastoma 36 | 1,855
primary Sjogren syndrome 36 | 735
Duchenne muscular dystrophy 35 | 601
pituitary cancer 35 | 1,972
esophageal adenocarcinoma 34 | 737
astrocytoma 33 | 1,146
gastric carcinoma 33 | 807
adrenocortical carcinoma 30 | 1,428
colon cancer 30 | 1,478
pediatric high grade glioma 28 | 1,064
Liver Cirrhosis, Experimental 27 | 769
Multiple myeloma 27 | 1,332
Pick disease 27 | 1,894
acute quadriplegic myopathy 25 | 1,158
Alzheimer's disease 24 | 658
Kidney disease 24 | 430
nasopharyngeal carcinoma 24 | 1,058
Arthritis 23 | 290
Down syndrome 23 | 499
mucosa-associated lymphoid tissue lymphoma 23 | 484
Anemia 22 | 365
Waldenstrons macroglobulinemia 22 | 765
active Crohn's disease 22 | 922
active ulcerative colitis 21 | 764
posterior fossa group A ependymoma 21 | 468
Breast Neoplasms 20 | 445
Human immunodeficiency virus infectious disease 20 | 138
autosomal dominant Emery-Dreifuss muscular dystrophy 20 | 510
Liver disease 19 | 237
acute myeloid leukemia 19 | 783
Asthma 18 | 385
Mammary Neoplasms 18 | 425
Vascular disease 18 | 319
Atherosclerosis 17 | 291
Bipolar Disorder 17 | 666
Coronary artery disease 17 | 268
Hepatitis B 17 | 108
Intellectual disability 17 | 1,016
nephrosclerosis 17 | 333
periodontitis 17 | 293
Ankylosing spondylitis 16 | 140
Atopic dermatitis 16 | 952
Dull intelligence 16 | 645
Endometriosis 16 | 540
Low intelligence 16 | 645
Mental Retardation 16 | 645
Mental deficiency 16 | 645
Poor school performance 16 | 645
head and neck cancer and chronic obstructive pulmonary disease 16 | 239
Obesity 15 | 678
sarcoidosis 15 | 370
Juvenile rheumatoid arthritis 14 | 111
Melanoma 14 | 711
Seizures 14 | 596
Becker muscular dystrophy 13 | 191

Tissue

Endocrine System 238 | 18,159
Female tissues 238 | 17,400
Urinary Tract 238 | 16,678
Blood and immune system 237 | 16,909
Digestive Tract 237 | 17,369
Liver and Pancreas 237 | 16,750
Male tissues 237 | 17,142
Respiratory system 236 | 16,393
Skin and soft tissues 236 | 17,230
Nervous System 234 | 16,725
Cardiovascular System 231 | 15,192

Target Family

Non-IDG 186 | 12,091
Enzyme 22 | 4,145
Kinase 14 | 634
Transporter 14 | 473
GPCR 13 | 408
Ion Channel 6 | 344

CSPA Cell Line

B-ALL 255 | 255
U-251 MG 405 | 405
Glioblastoma 376 | 376
LN18 359 | 359
HEK 329 | 329
Melanoma NSph 305 | 305
U-2 OS 286 | 286
LN229 283 | 283
RD 277 | 277
T98G 276 | 276
Rh28 265 | 265
ZL55 MPM 262 | 262
HeLa 260 | 260
Adipocytes 259 | 259
MelanomaAdh 243 | 243
A431 242 | 242
U-87 MG 242 | 242
Ruch-2 240 | 240
IMR-32 231 | 231
SDM104 228 | 228
P493-6 227 | 227
SDM5 221 | 221
L428 218 | 218
PASMC 217 | 217
CD4+CD25-Tcells 213 | 213
SDM4 211 | 211
KMH2 194 | 194
HDLM-2 193 | 193
HCC4012 192 | 192
MedB1 189 | 189
Jurkat 188 | 188
NK cells 182 | 182
NB4 181 | 181
L540 179 | 179
HBL-1 171 | 171
U2932 171 | 171
CaLu3 167 | 167
Lymphoma 163 | 163
SU-DHL-6 160 | 160
LNT229 154 | 154
SU4 (SU-DHL-4) 154 | 154
HL-60 146 | 146
786-O 112 | 112
SDM34 86 | 86
RH4 67 | 67
Braintumor 66 | 66
hMSC 59 | 59

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Adhesion G-protein coupled receptor G1 ADGRG1 Tbio GPCR -1.94601 100.6 182
Neuroplastin NPTN Tbio Non-IDG -2.31075 211.6 201
Leukocyte-associated immunoglobulin-like receptor 1 LAIR1 Tbio Non-IDG -1.74760 64.2 487
CD109 antigen CD109 Tbio Non-IDG -1.85817 77.8 239
Sodium bicarbonate cotransporter 3 SLC4A7 Tbio Transporter -1.82039 64.7 133
Endoglin ENG Tbio Non-IDG -3.10482 1235.9 1622
Junctional adhesion molecule A F11R Tbio Non-IDG -2.56739 380.0 394
Proteinase-activated receptor 4 F2RL3 Tchem GPCR -1.50044 34.1 276
Trophoblast glycoprotein TPBG Tbio Non-IDG -2.10560 136.9 206