Targets

Target Filters...

This is where graphics are reside..

Name	Gene	Development Level	Target Family	Log Novelty	Pubmed Score	Antibody Count
Trophoblast glycoprotein	TPBG	Tbio	Non-IDG	-2.10560	136.9	206
Choline transporter-like protein 1	SLC44A1	Tbio	Transporter	-1.60796	43.9	212
Scavenger receptor cysteine-rich type 1 protein M130	CD163	Tbio	Non-IDG	-2.93036	825.2	985
Integrin alpha-7	ITGA7	Tbio	Non-IDG	-1.63563	42.4	193
Leukocyte-associated immunoglobulin-like receptor 1	LAIR1	Tbio	Non-IDG	-1.74760	64.2	487
CD109 antigen	CD109	Tbio	Non-IDG	-1.85817	77.8	239
Neuroplastin	NPTN	Tbio	Non-IDG	-2.31075	211.6	201
Stabilin-1	STAB1	Tbio	Non-IDG	-1.61013	45.4	107
Endothelin-converting enzyme 1	ECE1	Tchem	Enzyme	-2.56360	355.0	278
Transmembrane glycoprotein NMB	GPNMB	Tbio	Non-IDG	-2.05817	130.8	293

	Tbio	187 \| 11,445
	Tchem	45 \| 1,598
	Tclin	18 \| 613
	Tdark	9 \| 6,588

	GPCR: IDG Consortium (Complete...	2 \| 25
	GPCR: IDG Consortium (Targets)	1 \| 126
	RFA-RM-18-021	1 \| 328

	preweaning lethality, incomple...	10 \| 499
	preweaning lethality, complete...	9 \| 979
	abnormal behavior	8 \| 298
	decreased vertical activity	8 \| 208
	decreased total body fat amoun...	6 \| 207
	enlarged heart	5 \| 210
	increased heart weight	5 \| 62
	abnormal seminal vesicle morph...	4 \| 114
	decreased leukocyte cell numbe...	4 \| 73
	impaired glucose tolerance	4 \| 75
	improved glucose tolerance	4 \| 79
	increased bone mineral content	4 \| 108
	increased lean body mass	4 \| 172
	tremors	4 \| 39
	abnormal bone structure	3 \| 187
	abnormal coat appearance	3 \| 31
	abnormal embryo size	3 \| 220
	abnormal eye morphology	3 \| 68
	abnormal gait	3 \| 69
	abnormal sleep behavior	3 \| 70
	decreased body length	3 \| 101
	decreased circulating glucose ...	3 \| 126
	decreased grip strength	3 \| 116
	decreased mean corpuscular vol...	3 \| 79
	decreased prepulse inhibition	3 \| 82
	decreased startle reflex	3 \| 75
	embryonic lethality prior to t...	3 \| 278
	hyperactivity	3 \| 148
	hypoactivity	3 \| 132
	increased or absent threshold ...	3 \| 101
	abnormal coat-hair pigmentatio...	2 \| 64
	abnormal ear morphology	2 \| 9
	abnormal limb bud morphology	2 \| 17
	abnormal skin morphology	2 \| 50
	cardiovascular system phenotyp...	2 \| 36
	decreased body weight	2 \| 161
	decreased bone mineral content	2 \| 151
	decreased bone mineral density	2 \| 126
	decreased cardiac muscle contr...	2 \| 11
	decreased circulating choleste...	2 \| 93
	decreased circulating triglyce...	2 \| 79
	decreased erythrocyte cell num...	2 \| 62
	decreased exploration in new e...	2 \| 11
	decreased fasted circulating g...	2 \| 65
	decreased hematocrit	2 \| 46
	decreased hemoglobin content	2 \| 68
	decreased mean corpuscular hem...	2 \| 50
	decreased mean corpuscular hem...	2 \| 31
	dilated heart left ventricle	2 \| 11
	embryonic growth retardation	2 \| 106
	enlarged spleen	2 \| 41
	increased circulating bilirubi...	2 \| 16
	increased circulating choleste...	2 \| 66
	increased mean corpuscular hem...	2 \| 96
	increased mean corpuscular vol...	2 \| 92
	male infertility	2 \| 123
	pallor	2 \| 34
	prolonged ST segment	2 \| 36
	short tibia	2 \| 97
	abnormal behavioral response t...	1 \| 66
	abnormal epididymis morphology	1 \| 42
	abnormal liver morphology	1 \| 17
	abnormal locomotor activation	1 \| 16
	abnormal lung morphology	1 \| 26
	abnormal pericardium morpholog...	1 \| 26
	abnormal placenta size	1 \| 20
	abnormal retina morphology	1 \| 71
	abnormal tail movements	1 \| 12
	abnormal urinary bladder morph...	1 \| 11
	abnormal vibrissa morphology	1 \| 25
	absent startle reflex	1 \| 24
	absent vibrissae	1 \| 12
	decreased T cell number	1 \| 15
	decreased circulating HDL chol...	1 \| 68
	decreased circulating calcium ...	1 \| 36
	decreased circulating creatini...	1 \| 39
	decreased circulating iron lev...	1 \| 32
	decreased circulating phosphat...	1 \| 27
	decreased eosinophil cell numb...	1 \| 24
	decreased heart rate variabili...	1 \| 13
	decreased mean platelet volume	1 \| 25
	decreased neutrophil cell numb...	1 \| 42
	decreased total retina thickne...	1 \| 17
	enlarged epididymis	1 \| 31
	enlarged lymph nodes	1 \| 37
	increased aggression	1 \| 4
	increased body weight	1 \| 25
	increased bone mineral density	1 \| 72
	increased circulating iron lev...	1 \| 30
	increased circulating triglyce...	1 \| 42
	increased exploration in new e...	1 \| 8
	increased heart rate	1 \| 23
	increased hematocrit	1 \| 46
	increased hemoglobin content	1 \| 45
	increased leukocyte cell numbe...	1 \| 47
	increased mean platelet volume	1 \| 45
	increased total body fat amoun...	1 \| 134
	microphthalmia	1 \| 26
	premature death	1 \| 5
	vertebral fusion	1 \| 23

	Carcinoma	191 \| 11,493
	ovarian cancer	161 \| 8,520
	glioblastoma	138 \| 5,792
	psoriasis	132 \| 6,694
	osteosarcoma	126 \| 7,950
	lung cancer	125 \| 4,740
	lung carcinoma	119 \| 2,843
	invasive ductal carcinoma	118 \| 2,951
	Cancer	106 \| 2,499
	ependymoma	105 \| 4,679
	intraductal papillary-mucinous adenoma (IPMA)	104 \| 2,955
	non-small cell lung cancer	104 \| 2,890
	Breast cancer	100 \| 3,578
	atypical teratoid / rhabdoid tumor	97 \| 5,112
	malignant mesothelioma	97 \| 3,232
	medulloblastoma, large-cell	96 \| 6,241
	Astrocytoma, Pilocytic	95 \| 3,081
	intraductal papillary-mucinous carcinoma (IPMC)	95 \| 2,989
	intraductal papillary-mucinous neoplasm (IPMN)	94 \| 3,291
	lung adenocarcinoma	92 \| 2,716
	pancreatic cancer	91 \| 2,398
	diabetes mellitus	82 \| 1,728
	adult high grade glioma	81 \| 3,801
	ductal carcinoma in situ	79 \| 1,745
	interstitial cystitis	78 \| 2,312
	breast carcinoma	72 \| 1,638
	ulcerative colitis	71 \| 1,819
	group 3 medulloblastoma	64 \| 4,104
	tuberculosis	62 \| 2,010
	Duchenne muscular dystrophy	60 \| 601
	cystic fibrosis	60 \| 1,696
	subependymal giant cell astrocytoma	59 \| 2,287
	primary pancreatic ductal adenocarcinoma	58 \| 1,109
	pituitary cancer	57 \| 1,972
	Kidney cancer	56 \| 2,613
	juvenile dermatomyositis	56 \| 1,187
	colon cancer	55 \| 1,478
	adrenocortical carcinoma	54 \| 1,428
	oligodendroglioma	54 \| 2,850
	pancreatic ductal adenocarcinoma liver metastasis	53 \| 1,962
	primitive neuroectodermal tumor	47 \| 3,035
	Autosomal recessive predisposition	46 \| 1,442
	Liver Cirrhosis, Experimental	44 \| 769
	Atopic dermatitis	43 \| 952
	autosomal dominant Emery-Dreifuss muscular dystrophy	41 \| 510
	dermatomyositis	41 \| 966
	astrocytic glioma	39 \| 2,597
	Kidney disease	38 \| 430
	esophageal adenocarcinoma	38 \| 737
	Rheumatoid arthritis	37 \| 1,191
	gastric carcinoma	37 \| 807
	group 4 medulloblastoma	36 \| 1,855
	acute quadriplegic myopathy	35 \| 1,158
	Atherosclerosis	34 \| 291
	cutaneous lupus erythematosus	34 \| 1,057
	pediatric high grade glioma	32 \| 1,064
	Hypersensitivity reaction type II disease	31 \| 253
	Schizophrenia	31 \| 1,160
	astrocytoma	31 \| 1,146
	limb girdle muscular dystrophy 2A	31 \| 213
	Coronary artery disease	30 \| 268
	Hypertension	30 \| 396
	nasopharyngeal carcinoma	30 \| 1,058
	mucosa-associated lymphoid tissue lymphoma	29 \| 484
	Alzheimer's disease	28 \| 658
	Down syndrome	28 \| 499
	Pick disease	28 \| 1,894
	Vascular disease	28 \| 319
	primary Sjogren syndrome	28 \| 735
	Anemia	27 \| 365
	fibroadenoma	27 \| 559
	Endometriosis	26 \| 540
	Multiple Sclerosis	26 \| 540
	active ulcerative colitis	26 \| 764
	Becker muscular dystrophy	25 \| 191
	Liver disease	24 \| 237
	active Crohn's disease	24 \| 922
	Obesity	23 \| 678
	Cerebrovascular disease	22 \| 238
	Hypertensive disease	22 \| 292
	Prostatic Neoplasms	21 \| 495
	Arthritis	20 \| 290
	nephrosclerosis	20 \| 333
	Melanoma	19 \| 711
	Asthma	18 \| 385
	Multiple myeloma	18 \| 1,332
	aldosterone-producing adenoma	18 \| 665
	Bipolar Disorder	17 \| 666
	Breast Neoplasms	17 \| 445
	Heart disease	17 \| 306
	Liver cancer	17 \| 604
	Muscle hypotonia	17 \| 571
	Waldenstrons macroglobulinemia	17 \| 765
	acute myeloid leukemia	17 \| 783
	urothelial carcinoma	17 \| 318
	Depressive disorder	16 \| 409
	Mammary Neoplasms	16 \| 425
	Thrombocytopenia	16 \| 197
	head and neck cancer and chronic obstructive pulmonary disease	16 \| 239
	medulloblastoma	16 \| 720

	Endocrine System	247 \| 18,159
	Digestive Tract	246 \| 17,369
	Female tissues	246 \| 17,400
	Liver and Pancreas	246 \| 16,750
	Skin and soft tissues	246 \| 17,230
	Blood and immune system	245 \| 16,909
	Male tissues	245 \| 17,142
	Urinary Tract	245 \| 16,678
	Respiratory system	243 \| 16,393
	Nervous System	242 \| 16,725
	Cardiovascular System	237 \| 15,192

Development Level

Collection

IMPC Phenotype

Disease

Tissue

Target Family

CSPA Cell Line

Drug Target Ontology

Target Development Level

Target Family

PANTHER Protein Ontology

Ligand

GTEx Tissue

HPA RNA Tissue

HPA Protein Tissue

HPM Tissue

JAX/MGI Phenotype

OMIM Phenotype

GWAS Trait

GO Component

UniProt Keywords

Data Source

	Non-IDG	191 \| 12,091
	Enzyme	32 \| 4,145
	GPCR	14 \| 408
	Transporter	10 \| 473
	Kinase	6 \| 634
	Ion Channel	5 \| 344
	Transcription Factor	1 \| 1,400

	Adipocytes	259 \| 259
	U-251 MG	405 \| 405
	Glioblastoma	376 \| 376
	LN18	359 \| 359
	HEK	329 \| 329
	Melanoma NSph	305 \| 305
	U-2 OS	286 \| 286
	LN229	283 \| 283
	RD	277 \| 277
	T98G	276 \| 276
	Rh28	265 \| 265
	ZL55 MPM	262 \| 262
	HeLa	260 \| 260
	B-ALL	255 \| 255
	MelanomaAdh	243 \| 243
	A431	242 \| 242
	U-87 MG	242 \| 242
	Ruch-2	240 \| 240
	IMR-32	231 \| 231
	SDM104	228 \| 228
	P493-6	227 \| 227
	SDM5	221 \| 221
	L428	218 \| 218
	PASMC	217 \| 217
	CD4+CD25-Tcells	213 \| 213
	SDM4	211 \| 211
	KMH2	194 \| 194
	HDLM-2	193 \| 193
	HCC4012	192 \| 192
	MedB1	189 \| 189
	Jurkat	188 \| 188
	NK cells	182 \| 182
	NB4	181 \| 181
	L540	179 \| 179
	HBL-1	171 \| 171
	U2932	171 \| 171
	CaLu3	167 \| 167
	Lymphoma	163 \| 163
	SU-DHL-6	160 \| 160
	LNT229	154 \| 154
	SU4 (SU-DHL-4)	154 \| 154
	HL-60	146 \| 146
	786-O	112 \| 112
	SDM34	86 \| 86
	RH4	67 \| 67
	Braintumor	66 \| 66
	hMSC	59 \| 59