1. Home
  2. Targets
Target Filters...

Development Level

Tbio 187 | 11,445
Tchem 45 | 1,598
Tclin 18 | 613
Tdark 9 | 6,588

Collection

GPCR: IDG Consortium (Complete... 2 | 25
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, incomple... 10 | 499
preweaning lethality, complete... 9 | 979
abnormal behavior 8 | 298
decreased vertical activity 8 | 208
decreased total body fat amoun... 6 | 207
enlarged heart 5 | 210
increased heart weight 5 | 62
abnormal seminal vesicle morph... 4 | 114
decreased leukocyte cell numbe... 4 | 73
impaired glucose tolerance 4 | 75
improved glucose tolerance 4 | 79
increased bone mineral content 4 | 108
increased lean body mass 4 | 172
tremors 4 | 39
abnormal bone structure 3 | 187
abnormal coat appearance 3 | 31
abnormal embryo size 3 | 220
abnormal eye morphology 3 | 68
abnormal gait 3 | 69
abnormal sleep behavior 3 | 70
decreased body length 3 | 101
decreased circulating glucose ... 3 | 126
decreased grip strength 3 | 116
decreased mean corpuscular vol... 3 | 79
decreased prepulse inhibition 3 | 82
decreased startle reflex 3 | 75
embryonic lethality prior to t... 3 | 278
hyperactivity 3 | 148
hypoactivity 3 | 132
increased or absent threshold ... 3 | 101
abnormal coat-hair pigmentatio... 2 | 64
abnormal ear morphology 2 | 9
abnormal limb bud morphology 2 | 17
abnormal skin morphology 2 | 50
cardiovascular system phenotyp... 2 | 36
decreased body weight 2 | 161
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
decreased cardiac muscle contr... 2 | 11
decreased circulating choleste... 2 | 93
decreased circulating triglyce... 2 | 79
decreased erythrocyte cell num... 2 | 62
decreased exploration in new e... 2 | 11
decreased fasted circulating g... 2 | 65
decreased hematocrit 2 | 46
decreased hemoglobin content 2 | 68
decreased mean corpuscular hem... 2 | 50
decreased mean corpuscular hem... 2 | 31
dilated heart left ventricle 2 | 11
embryonic growth retardation 2 | 106
enlarged spleen 2 | 41
increased circulating bilirubi... 2 | 16
increased circulating choleste... 2 | 66
increased mean corpuscular hem... 2 | 96
increased mean corpuscular vol... 2 | 92
male infertility 2 | 123
pallor 2 | 34
prolonged ST segment 2 | 36
short tibia 2 | 97
abnormal behavioral response t... 1 | 66
abnormal epididymis morphology 1 | 42
abnormal liver morphology 1 | 17
abnormal locomotor activation 1 | 16
abnormal lung morphology 1 | 26
abnormal pericardium morpholog... 1 | 26
abnormal placenta size 1 | 20
abnormal retina morphology 1 | 71
abnormal tail movements 1 | 12
abnormal urinary bladder morph... 1 | 11
abnormal vibrissa morphology 1 | 25
absent startle reflex 1 | 24
absent vibrissae 1 | 12
decreased T cell number 1 | 15
decreased circulating HDL chol... 1 | 68
decreased circulating calcium ... 1 | 36
decreased circulating creatini... 1 | 39
decreased circulating iron lev... 1 | 32
decreased circulating phosphat... 1 | 27
decreased eosinophil cell numb... 1 | 24
decreased heart rate variabili... 1 | 13
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
decreased total retina thickne... 1 | 17
enlarged epididymis 1 | 31
enlarged lymph nodes 1 | 37
increased aggression 1 | 4
increased body weight 1 | 25
increased bone mineral density 1 | 72
increased circulating iron lev... 1 | 30
increased circulating triglyce... 1 | 42
increased exploration in new e... 1 | 8
increased heart rate 1 | 23
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased mean platelet volume 1 | 45
increased total body fat amoun... 1 | 134
microphthalmia 1 | 26
premature death 1 | 5
vertebral fusion 1 | 23

Disease

Carcinoma 191 | 11,493
ovarian cancer 161 | 8,520
glioblastoma 138 | 5,792
psoriasis 132 | 6,694
osteosarcoma 126 | 7,950
lung cancer 125 | 4,740
lung carcinoma 119 | 2,843
invasive ductal carcinoma 118 | 2,951
Cancer 106 | 2,499
ependymoma 105 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 104 | 2,955
non-small cell lung cancer 104 | 2,890
Breast cancer 100 | 3,578
atypical teratoid / rhabdoid tumor 97 | 5,112
malignant mesothelioma 97 | 3,232
medulloblastoma, large-cell 96 | 6,241
Astrocytoma, Pilocytic 95 | 3,081
intraductal papillary-mucinous carcinoma (IPMC) 95 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 94 | 3,291
lung adenocarcinoma 92 | 2,716
pancreatic cancer 91 | 2,398
diabetes mellitus 82 | 1,728
adult high grade glioma 81 | 3,801
ductal carcinoma in situ 79 | 1,745
interstitial cystitis 78 | 2,312
breast carcinoma 72 | 1,638
ulcerative colitis 71 | 1,819
group 3 medulloblastoma 64 | 4,104
tuberculosis 62 | 2,010
Duchenne muscular dystrophy 60 | 601
cystic fibrosis 60 | 1,696
subependymal giant cell astrocytoma 59 | 2,287
primary pancreatic ductal adenocarcinoma 58 | 1,109
pituitary cancer 57 | 1,972
Kidney cancer 56 | 2,613
juvenile dermatomyositis 56 | 1,187
colon cancer 55 | 1,478
adrenocortical carcinoma 54 | 1,428
oligodendroglioma 54 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 53 | 1,962
primitive neuroectodermal tumor 47 | 3,035
Autosomal recessive predisposition 46 | 1,442
Liver Cirrhosis, Experimental 44 | 769
Atopic dermatitis 43 | 952
autosomal dominant Emery-Dreifuss muscular dystrophy 41 | 510
dermatomyositis 41 | 966
astrocytic glioma 39 | 2,597
Kidney disease 38 | 430
esophageal adenocarcinoma 38 | 737
Rheumatoid arthritis 37 | 1,191
gastric carcinoma 37 | 807
group 4 medulloblastoma 36 | 1,855
acute quadriplegic myopathy 35 | 1,158
Atherosclerosis 34 | 291
cutaneous lupus erythematosus 34 | 1,057
pediatric high grade glioma 32 | 1,064
Hypersensitivity reaction type II disease 31 | 253
Schizophrenia 31 | 1,160
astrocytoma 31 | 1,146
limb girdle muscular dystrophy 2A 31 | 213
Coronary artery disease 30 | 268
Hypertension 30 | 396
nasopharyngeal carcinoma 30 | 1,058
mucosa-associated lymphoid tissue lymphoma 29 | 484
Alzheimer's disease 28 | 658
Down syndrome 28 | 499
Pick disease 28 | 1,894
Vascular disease 28 | 319
primary Sjogren syndrome 28 | 735
Anemia 27 | 365
fibroadenoma 27 | 559
Endometriosis 26 | 540
Multiple Sclerosis 26 | 540
active ulcerative colitis 26 | 764
Becker muscular dystrophy 25 | 191
Liver disease 24 | 237
active Crohn's disease 24 | 922
Obesity 23 | 678
Cerebrovascular disease 22 | 238
Hypertensive disease 22 | 292
Prostatic Neoplasms 21 | 495
Arthritis 20 | 290
nephrosclerosis 20 | 333
Melanoma 19 | 711
Asthma 18 | 385
Multiple myeloma 18 | 1,332
aldosterone-producing adenoma 18 | 665
Bipolar Disorder 17 | 666
Breast Neoplasms 17 | 445
Heart disease 17 | 306
Liver cancer 17 | 604
Muscle hypotonia 17 | 571
Waldenstrons macroglobulinemia 17 | 765
acute myeloid leukemia 17 | 783
urothelial carcinoma 17 | 318
Depressive disorder 16 | 409
Mammary Neoplasms 16 | 425
Thrombocytopenia 16 | 197
head and neck cancer and chronic obstructive pulmonary disease 16 | 239
medulloblastoma 16 | 720

Tissue

Endocrine System 247 | 18,159
Digestive Tract 246 | 17,369
Female tissues 246 | 17,400
Liver and Pancreas 246 | 16,750
Skin and soft tissues 246 | 17,230
Blood and immune system 245 | 16,909
Male tissues 245 | 17,142
Urinary Tract 245 | 16,678
Respiratory system 243 | 16,393
Nervous System 242 | 16,725
Cardiovascular System 237 | 15,192

Target Family

Non-IDG 191 | 12,091
Enzyme 32 | 4,145
GPCR 14 | 408
Transporter 10 | 473
Kinase 6 | 634
Ion Channel 5 | 344
Transcription Factor 1 | 1,400

CSPA Cell Line

Adipocytes 259 | 259
U-251 MG 405 | 405
Glioblastoma 376 | 376
LN18 359 | 359
HEK 329 | 329
Melanoma NSph 305 | 305
U-2 OS 286 | 286
LN229 283 | 283
RD 277 | 277
T98G 276 | 276
Rh28 265 | 265
ZL55 MPM 262 | 262
HeLa 260 | 260
B-ALL 255 | 255
MelanomaAdh 243 | 243
A431 242 | 242
U-87 MG 242 | 242
Ruch-2 240 | 240
IMR-32 231 | 231
SDM104 228 | 228
P493-6 227 | 227
SDM5 221 | 221
L428 218 | 218
PASMC 217 | 217
CD4+CD25-Tcells 213 | 213
SDM4 211 | 211
KMH2 194 | 194
HDLM-2 193 | 193
HCC4012 192 | 192
MedB1 189 | 189
Jurkat 188 | 188
NK cells 182 | 182
NB4 181 | 181
L540 179 | 179
HBL-1 171 | 171
U2932 171 | 171
CaLu3 167 | 167
Lymphoma 163 | 163
SU-DHL-6 160 | 160
LNT229 154 | 154
SU4 (SU-DHL-4) 154 | 154
HL-60 146 | 146
786-O 112 | 112
SDM34 86 | 86
RH4 67 | 67
Braintumor 66 | 66
hMSC 59 | 59

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Prothrombin F2 Tclin Enzyme -4.53745 33691.4 579
Angiotensin-converting enzyme ACE Tclin Enzyme -4.52754 30363.8 643
Hematopoietic progenitor cell antigen CD34 CD34 Tbio Non-IDG -4.14691 13698.4 1952
Tissue factor F3 Tchem Non-IDG -4.06839 11133.9 591
Kininogen-1 KNG1 Tchem Non-IDG -4.06379 11365.4 439
Epidermal growth factor receptor EGFR Tclin Kinase -4.02650 10013.1 6418