Development Level

Tbio 173 | 11,178
Tchem 60 | 1,885
Tclin 18 | 612
Tdark 8 | 6,569

Collection

GPCR: IDG Consortium (Complete... 2 | 25
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, incomple... 10 | 499
preweaning lethality, complete... 9 | 979
abnormal behavior 8 | 298
decreased vertical activity 8 | 208
decreased total body fat amoun... 6 | 207
enlarged heart 5 | 210
increased heart weight 5 | 62
abnormal seminal vesicle morph... 4 | 114
decreased leukocyte cell numbe... 4 | 73
impaired glucose tolerance 4 | 75
improved glucose tolerance 4 | 79
increased bone mineral content 4 | 108
increased lean body mass 4 | 172
tremors 4 | 39
abnormal bone structure 3 | 187
abnormal coat appearance 3 | 31
abnormal embryo size 3 | 220
abnormal eye morphology 3 | 68
abnormal gait 3 | 69
abnormal sleep behavior 3 | 70
decreased body length 3 | 101
decreased circulating glucose ... 3 | 126
decreased grip strength 3 | 116
decreased mean corpuscular vol... 3 | 79
decreased prepulse inhibition 3 | 82
decreased startle reflex 3 | 75
embryonic lethality prior to t... 3 | 278
hyperactivity 3 | 148
hypoactivity 3 | 132
increased or absent threshold ... 3 | 101
abnormal coat-hair pigmentatio... 2 | 64
abnormal ear morphology 2 | 9
abnormal limb bud morphology 2 | 17
abnormal skin morphology 2 | 50
cardiovascular system phenotyp... 2 | 36
decreased body weight 2 | 161
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
decreased cardiac muscle contr... 2 | 11
decreased circulating choleste... 2 | 93
decreased circulating triglyce... 2 | 79
decreased erythrocyte cell num... 2 | 62
decreased exploration in new e... 2 | 11
decreased fasted circulating g... 2 | 65
decreased hematocrit 2 | 46
decreased hemoglobin content 2 | 68
decreased mean corpuscular hem... 2 | 50
decreased mean corpuscular hem... 2 | 31
dilated heart left ventricle 2 | 11
embryonic growth retardation 2 | 106
enlarged spleen 2 | 41
increased circulating bilirubi... 2 | 16
increased circulating choleste... 2 | 66
increased mean corpuscular hem... 2 | 96
increased mean corpuscular vol... 2 | 92
male infertility 2 | 123
pallor 2 | 34
prolonged ST segment 2 | 36
short tibia 2 | 97
abnormal behavioral response t... 1 | 66
abnormal epididymis morphology 1 | 42
abnormal liver morphology 1 | 17
abnormal locomotor activation 1 | 16
abnormal lung morphology 1 | 26
abnormal pericardium morpholog... 1 | 26
abnormal placenta size 1 | 20
abnormal retina morphology 1 | 71
abnormal tail movements 1 | 12
abnormal urinary bladder morph... 1 | 11
abnormal vibrissa morphology 1 | 25
absent startle reflex 1 | 24
absent vibrissae 1 | 12
decreased T cell number 1 | 15
decreased circulating HDL chol... 1 | 68
decreased circulating calcium ... 1 | 36
decreased circulating creatini... 1 | 39
decreased circulating iron lev... 1 | 32
decreased circulating phosphat... 1 | 27
decreased eosinophil cell numb... 1 | 24
decreased heart rate variabili... 1 | 13
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
decreased total retina thickne... 1 | 17
enlarged epididymis 1 | 31
enlarged lymph nodes 1 | 37
increased aggression 1 | 4
increased body weight 1 | 25
increased bone mineral density 1 | 72
increased circulating iron lev... 1 | 30
increased circulating triglyce... 1 | 42
increased exploration in new e... 1 | 8
increased heart rate 1 | 23
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased mean platelet volume 1 | 45
increased total body fat amoun... 1 | 134
microphthalmia 1 | 26
premature death 1 | 5
vertebral fusion 1 | 23

Disease

Carcinoma 179 | 11,192
ovarian cancer 154 | 8,297
glioblastoma 132 | 5,635
psoriasis 126 | 6,514
lung cancer 119 | 4,607
osteosarcoma 119 | 7,766
invasive ductal carcinoma 112 | 2,867
lung carcinoma 112 | 2,755
ependymoma 101 | 4,559
intraductal papillary-mucinous adenoma (IPMA) 100 | 2,872
non-small cell lung cancer 97 | 2,799
Cancer 95 | 2,388
malignant mesothelioma 95 | 3,135
Breast cancer 93 | 3,469
Astrocytoma, Pilocytic 91 | 3,006
medulloblastoma, large-cell 91 | 6,086
atypical teratoid / rhabdoid tumor 90 | 4,971
intraductal papillary-mucinous carcinoma (IPMC) 90 | 2,902
intraductal papillary-mucinous neoplasm (IPMN) 89 | 3,204
lung adenocarcinoma 88 | 2,627
pancreatic cancer 86 | 2,322
adult high grade glioma 78 | 3,701
diabetes mellitus 78 | 1,683
interstitial cystitis 75 | 2,237
ductal carcinoma in situ 73 | 1,686
breast carcinoma 69 | 1,589
ulcerative colitis 67 | 1,765
group 3 medulloblastoma 60 | 4,002
tuberculosis 60 | 1,963
Duchenne muscular dystrophy 58 | 587
cystic fibrosis 57 | 1,629
pituitary cancer 56 | 1,915
subependymal giant cell astrocytoma 56 | 2,230
primary pancreatic ductal adenocarcinoma 55 | 1,071
colon cancer 53 | 1,428
Kidney cancer 52 | 2,548
adrenocortical carcinoma 52 | 1,385
juvenile dermatomyositis 52 | 1,147
oligodendroglioma 52 | 2,768
pancreatic ductal adenocarcinoma liver metastasis 50 | 1,911
primitive neuroectodermal tumor 44 | 2,957
Autosomal recessive predisposition 43 | 1,407
Atopic dermatitis 42 | 915
autosomal dominant Emery-Dreifuss muscular dystrophy 41 | 492
dermatomyositis 41 | 941
Liver Cirrhosis, Experimental 38 | 733
astrocytic glioma 37 | 2,530
esophageal adenocarcinoma 35 | 696
gastric carcinoma 35 | 781
group 4 medulloblastoma 35 | 1,806
Rheumatoid arthritis 34 | 1,156
Kidney disease 32 | 411
acute quadriplegic myopathy 32 | 1,133
cutaneous lupus erythematosus 31 | 1,016
Schizophrenia 30 | 1,136
astrocytoma 30 | 1,113
limb girdle muscular dystrophy 2A 30 | 208
pediatric high grade glioma 30 | 1,035
Atherosclerosis 29 | 276
mucosa-associated lymphoid tissue lymphoma 28 | 473
nasopharyngeal carcinoma 28 | 1,024
Hypersensitivity reaction type II disease 27 | 245
fibroadenoma 27 | 538
Coronary artery disease 26 | 253
Down syndrome 26 | 480
Pick disease 26 | 1,856
Hypertension 25 | 372
Multiple Sclerosis 25 | 527
primary Sjogren syndrome 25 | 710
Alzheimer's disease 24 | 640
Becker muscular dystrophy 24 | 184
Endometriosis 24 | 521
Vascular disease 24 | 294
active ulcerative colitis 24 | 736
Anemia 22 | 353
Liver disease 21 | 227
active Crohn's disease 21 | 882
Cerebrovascular disease 19 | 223
Obesity 19 | 655
Prostatic Neoplasms 19 | 472
Arthritis 18 | 276
Hypertensive disease 18 | 278
Melanoma 18 | 689
aldosterone-producing adenoma 18 | 646
Multiple myeloma 17 | 1,296
Muscle hypotonia 17 | 562
nephrosclerosis 17 | 314
Liver cancer 16 | 589
head and neck cancer and chronic obstructive pulmonary disease 16 | 226
medulloblastoma 16 | 702
Asthma 15 | 370
Bipolar Disorder 15 | 646
Depressive disorder 15 | 401
Hepatitis B 15 | 105
Waldenstrons macroglobulinemia 15 | 742
interstitial lung disease 15 | 287
non primary Sjogren syndrome sicca 15 | 861
sarcoidosis 15 | 357
urothelial carcinoma 15 | 303
acute myeloid leukemia 14 | 760

Tissue

Endocrine System 247 | 18,159
Digestive Tract 246 | 17,369
Female tissues 246 | 17,400
Liver and Pancreas 246 | 16,750
Skin and soft tissues 246 | 17,230
Blood and immune system 245 | 16,909
Male tissues 245 | 17,142
Urinary Tract 245 | 16,678
Respiratory system 243 | 16,393
Nervous System 242 | 16,725
Cardiovascular System 237 | 15,192

Target Family

Non-IDG 191 | 12,091
Enzyme 32 | 4,145
GPCR 14 | 408
Transporter 10 | 473
Kinase 6 | 634
Ion Channel 5 | 344
Transcription Factor 1 | 1,400

CSPA Cell Line

Adipocytes 259 | 259
U-251 MG 405 | 405
Glioblastoma 376 | 376
LN18 359 | 359
HEK 329 | 329
Melanoma NSph 305 | 305
U-2 OS 286 | 286
LN229 283 | 283
RD 277 | 277
T98G 276 | 276
Rh28 265 | 265
ZL55 MPM 262 | 262
HeLa 260 | 260
B-ALL 255 | 255
MelanomaAdh 243 | 243
A431 242 | 242
U-87 MG 242 | 242
Ruch-2 240 | 240
IMR-32 231 | 231
SDM104 228 | 228
P493-6 227 | 227
SDM5 221 | 221
L428 218 | 218
PASMC 217 | 217
CD4+CD25-Tcells 213 | 213
SDM4 211 | 211
KMH2 194 | 194
HDLM-2 193 | 193
HCC4012 192 | 192
MedB1 189 | 189
Jurkat 188 | 188
NK cells 182 | 182
NB4 181 | 181
L540 179 | 179
HBL-1 171 | 171
U2932 171 | 171
CaLu3 167 | 167
Lymphoma 163 | 163
SU-DHL-6 160 | 160
LNT229 154 | 154
SU4 (SU-DHL-4) 154 | 154
HL-60 146 | 146
786-O 112 | 112
SDM34 86 | 86
RH4 67 | 67
Braintumor 66 | 66
hMSC 59 | 59

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dystroglycan DAG1 Tbio Enzyme -2.77503 560.0 254
Nidogen-2 NID2 Tbio Non-IDG -1.62355 40.1 116
Cathepsin D CTSD Tchem Enzyme -3.47061 2866.8 779
Insulin receptor INSR Tclin Kinase -2.50045 306.8 1417
Embigin EMB Tbio Non-IDG -2.79800 638.6 103
BDNF/NT-3 growth factors receptor NTRK2 Tchem Kinase -3.14477 1170.3 947
Prostaglandin F2 receptor negative regulator PTGFRN Tbio Non-IDG -1.42165 26.8 105
Desmoglein-2 DSG2 Tbio Non-IDG -2.03972 117.7 407
Collagen alpha-6(VI) chain COL6A6 Tchem Non-IDG -0.48745 3.28 27
C-type mannose receptor 2 MRC2 Tbio Non-IDG -1.86592 83.0 174