Development Level

Tbio 176 | 11,445
Tchem 35 | 1,598
Tclin 18 | 613
Tdark 13 | 6,588

Collection

GPCR: IDG Consortium (Complete... 3 | 25
GPCR: IDG Consortium (Targets) 3 | 126

IMPC Phenotype

preweaning lethality, incomple... 9 | 499
abnormal behavior 8 | 298
preweaning lethality, complete... 8 | 979
decreased vertical activity 6 | 208
decreased total body fat amoun... 5 | 207
enlarged heart 5 | 210
hyperactivity 4 | 148
increased bone mineral content 4 | 108
abnormal bone structure 3 | 187
abnormal coat appearance 3 | 31
abnormal embryo size 3 | 220
abnormal eye morphology 3 | 68
abnormal seminal vesicle morph... 3 | 114
decreased circulating triglyce... 3 | 79
embryonic lethality prior to t... 3 | 278
hypoactivity 3 | 132
improved glucose tolerance 3 | 79
increased circulating choleste... 3 | 66
increased heart weight 3 | 62
pale yolk sac 3 | 25
abnormal ear morphology 2 | 9
abnormal gait 2 | 69
abnormal heart morphology 2 | 162
abnormal kidney morphology 2 | 65
abnormal limb bud morphology 2 | 17
decreased cardiac muscle contr... 2 | 11
decreased circulating glucose ... 2 | 126
decreased eosinophil cell numb... 2 | 24
decreased grip strength 2 | 116
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
decreased prepulse inhibition 2 | 82
decreased startle reflex 2 | 75
embryonic growth retardation 2 | 106
embryonic lethality prior to o... 2 | 239
impaired glucose tolerance 2 | 75
increased body weight 2 | 25
increased circulating glycerol... 2 | 9
increased circulating thyroxin... 2 | 7
increased circulating triglyce... 2 | 42
increased erythrocyte cell num... 2 | 39
increased lean body mass 2 | 172
increased leukocyte cell numbe... 2 | 47
increased mean corpuscular vol... 2 | 92
increased total body fat amoun... 2 | 134
pallor 2 | 34
polycystic kidney 2 | 15
tremors 2 | 39
abnormal allantois morphology 1 | 8
abnormal cornea morphology 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal head morphology 1 | 10
abnormal left-right axis patte... 1 | 2
abnormal lens morphology 1 | 81
abnormal locomotor activation 1 | 16
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal pericardium morpholog... 1 | 26
abnormal retina morphology 1 | 71
abnormal snout morphology 1 | 23
abnormal somite shape 1 | 5
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal tooth morphology 1 | 24
abnormal urinary bladder morph... 1 | 11
abnormal vertebrae morphology 1 | 18
abnormal vibrissa morphology 1 | 25
abnormal vitelline vasculature... 1 | 6
abnormal vocalization 1 | 21
absent vibrissae 1 | 12
cataract 1 | 92
corneal opacity 1 | 32
decreased body length 1 | 101
decreased circulating bilirubi... 1 | 19
decreased circulating phosphat... 1 | 27
decreased erythrocyte cell num... 1 | 62
decreased mean corpuscular hem... 1 | 31
dilated heart left ventricle 1 | 11
enlarged epididymis 1 | 31
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
enlarged uterus 1 | 11
hydrometra 1 | 53
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating creatini... 1 | 38
increased circulating fructosa... 1 | 13
increased circulating iron lev... 1 | 30
increased circulating total pr... 1 | 28
increased fasted circulating g... 1 | 76
increased heart rate 1 | 23
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased monocyte cell number 1 | 63
microphthalmia 1 | 26
small testis 1 | 58
trunk curl 1 | 16

Disease

Carcinoma 192 | 11,493
ovarian cancer 163 | 8,520
glioblastoma 129 | 5,792
osteosarcoma 125 | 7,950
psoriasis 112 | 6,694
lung cancer 106 | 4,740
Cancer 104 | 2,499
lung carcinoma 101 | 2,843
medulloblastoma, large-cell 101 | 6,241
malignant mesothelioma 96 | 3,232
ependymoma 95 | 4,679
Breast cancer 91 | 3,578
atypical teratoid / rhabdoid tumor 91 | 5,112
pancreatic cancer 89 | 2,398
Astrocytoma, Pilocytic 86 | 3,081
non-small cell lung cancer 81 | 2,890
intraductal papillary-mucinous neoplasm (IPMN) 80 | 3,291
invasive ductal carcinoma 75 | 2,951
lung adenocarcinoma 75 | 2,716
interstitial cystitis 71 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 70 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 68 | 2,989
adult high grade glioma 64 | 3,801
cystic fibrosis 62 | 1,696
ulcerative colitis 62 | 1,819
group 3 medulloblastoma 61 | 4,104
Kidney cancer 60 | 2,613
oligodendroglioma 57 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 56 | 1,962
tuberculosis 55 | 2,010
subependymal giant cell astrocytoma 53 | 2,287
ductal carcinoma in situ 52 | 1,745
astrocytic glioma 47 | 2,597
primitive neuroectodermal tumor 47 | 3,035
group 4 medulloblastoma 46 | 1,855
juvenile dermatomyositis 46 | 1,187
diabetes mellitus 42 | 1,728
Autosomal recessive predisposition 40 | 1,442
primary pancreatic ductal adenocarcinoma 39 | 1,109
breast carcinoma 38 | 1,638
esophageal adenocarcinoma 38 | 737
acute quadriplegic myopathy 36 | 1,158
pituitary cancer 36 | 1,972
pediatric high grade glioma 35 | 1,064
cutaneous lupus erythematosus 33 | 1,057
nasopharyngeal carcinoma 33 | 1,058
adrenocortical carcinoma 32 | 1,428
dermatomyositis 32 | 966
Duchenne muscular dystrophy 31 | 601
gastric carcinoma 31 | 807
Pick disease 29 | 1,894
Rheumatoid arthritis 29 | 1,191
astrocytoma 29 | 1,146
colon cancer 29 | 1,478
autosomal dominant Emery-Dreifuss muscular dystrophy 28 | 510
Multiple Sclerosis 27 | 540
active ulcerative colitis 27 | 764
Multiple myeloma 26 | 1,332
Hypersensitivity reaction type II disease 25 | 253
active Crohn's disease 25 | 922
spina bifida 25 | 1,074
Alzheimer's disease 23 | 658
Atopic dermatitis 23 | 952
Breast Neoplasms 23 | 445
Liver Cirrhosis, Experimental 23 | 769
Anemia 22 | 365
Prostatic Neoplasms 22 | 495
mucosa-associated lymphoid tissue lymphoma 22 | 484
Down syndrome 21 | 499
Mammary Neoplasms 21 | 425
Kidney disease 19 | 430
Schizophrenia 19 | 1,160
Endometriosis 18 | 540
Arthritis 17 | 290
Barrett's esophagus 17 | 182
acute myeloid leukemia 17 | 783
fibroadenoma 17 | 559
Liver disease 16 | 237
Neoplasm Metastasis 16 | 168
Stomach Neoplasms 16 | 300
Vascular disease 16 | 319
aldosterone-producing adenoma 16 | 665
posterior fossa group A ependymoma 16 | 468
primary Sjogren syndrome 16 | 735
Atherosclerosis 15 | 291
Coronary artery disease 15 | 268
Liver cancer 15 | 604
Melanoma 15 | 711
Myocardial Ischemia 14 | 169
Neoplasm Invasiveness 14 | 161
Waldenstrons macroglobulinemia 14 | 765
Asthma 13 | 385
Intellectual disability 13 | 1,016
Juvenile rheumatoid arthritis 13 | 111
interstitial lung disease 13 | 298
non-small cell lung carcinoma 13 | 317
Dull intelligence 12 | 645
Mental deficiency 12 | 645
Poor school performance 12 | 645
nephrosclerosis 12 | 333

Tissue

Female tissues 234 | 17,400
Respiratory system 234 | 16,393
Blood and immune system 233 | 16,909
Digestive Tract 233 | 17,369
Endocrine System 233 | 18,159
Skin and soft tissues 233 | 17,230
Urinary Tract 232 | 16,678
Male tissues 231 | 17,142
Liver and Pancreas 230 | 16,750
Nervous System 229 | 16,725
Cardiovascular System 227 | 15,192

Target Family

Non-IDG 163 | 12,091
Enzyme 27 | 4,145
Kinase 17 | 634
Transporter 17 | 473
GPCR 13 | 408
Ion Channel 3 | 344
Transcription Factor 2 | 1,400

CSPA Cell Line

A431 242 | 242
U-251 MG 405 | 405
Glioblastoma 376 | 376
LN18 359 | 359
HEK 329 | 329
Melanoma NSph 305 | 305
U-2 OS 286 | 286
LN229 283 | 283
RD 277 | 277
T98G 276 | 276
Rh28 265 | 265
ZL55 MPM 262 | 262
HeLa 260 | 260
Adipocytes 259 | 259
B-ALL 255 | 255
MelanomaAdh 243 | 243
U-87 MG 242 | 242
Ruch-2 240 | 240
IMR-32 231 | 231
SDM104 228 | 228
P493-6 227 | 227
SDM5 221 | 221
L428 218 | 218
PASMC 217 | 217
CD4+CD25-Tcells 213 | 213
SDM4 211 | 211
KMH2 194 | 194
HDLM-2 193 | 193
HCC4012 192 | 192
MedB1 189 | 189
Jurkat 188 | 188
NK cells 182 | 182
NB4 181 | 181
L540 179 | 179
HBL-1 171 | 171
U2932 171 | 171
CaLu3 167 | 167
Lymphoma 163 | 163
SU-DHL-6 160 | 160
LNT229 154 | 154
SU4 (SU-DHL-4) 154 | 154
HL-60 146 | 146
786-O 112 | 112
SDM34 86 | 86
RH4 67 | 67
Braintumor 66 | 66
hMSC 59 | 59

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Adhesion G-protein coupled receptor G1 ADGRG1 Tbio GPCR -1.94601 100.6 182
Neuroplastin NPTN Tbio Non-IDG -2.31075 211.6 201
CD109 antigen CD109 Tbio Non-IDG -1.85817 77.8 239
Mucin-16 MUC16 Tbio Non-IDG -2.09951 138.4 0
Sodium bicarbonate cotransporter 3 SLC4A7 Tbio Transporter -1.82039 64.7 133
Junctional adhesion molecule A F11R Tbio Non-IDG -2.56739 380.0 394
G-protein coupled receptor 39 GPR39 Tchem GPCR -1.77076 66.5 232
VPS10 domain-containing receptor SorCS2 SORCS2 Tbio Non-IDG -0.79588 6.26 56
Folate receptor alpha FOLR1 Tchem Non-IDG -2.33242 206.1 303