| Tdark | Protein zyg-11 homolog B |
Probably acts as target recruitment subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC.
Comments
| Disease | Target Count | P-value |
|---|---|---|
| osteosarcoma | 7950 | 3.2e-09 |
| atypical teratoid / rhabdoid tumor | 5112 | 1.7e-07 |
| ovarian cancer | 8520 | 1.1e-06 |
| glioblastoma | 5792 | 5.9e-06 |
| medulloblastoma, large-cell | 6241 | 8.1e-05 |
| primitive neuroectodermal tumor | 3035 | 4.4e-04 |
| Duchenne muscular dystrophy | 601 | 4.8e-04 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 7.6e-04 |
| adult high grade glioma | 3801 | 1.0e-03 |
| Astrocytoma, Pilocytic | 3081 | 1.3e-03 |
| group 4 medulloblastoma | 1855 | 3.8e-03 |
| limb girdle muscular dystrophy 2A | 213 | 4.9e-03 |
| Rheumatoid arthritis | 1191 | 7.9e-03 |
| pancreatic cancer | 2398 | 8.0e-03 |
| Pick disease | 1894 | 9.0e-03 |
| autosomal dominant Emery-Dreifuss muscular dystrophy | 510 | 1.3e-02 |
| cystic fibrosis and chronic rhinosinusitis | 214 | 2.6e-02 |
| ependymoma | 4679 | 4.7e-02 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -1.400 | 1.0e-03 |
| Astrocytoma, Pilocytic | -1.100 | 1.3e-03 |
| atypical teratoid / rhabdoid tumor | -1.900 | 1.7e-07 |
| autosomal dominant Emery-Dreifuss muscul... | -1.460 | 1.3e-02 |
| cystic fibrosis and chronic rhinosinusit... | -1.010 | 2.6e-02 |
| Duchenne muscular dystrophy | -1.580 | 4.8e-04 |
| ependymoma | -1.300 | 4.7e-02 |
| glioblastoma | -1.800 | 5.9e-06 |
| group 4 medulloblastoma | 1.400 | 3.8e-03 |
| limb girdle muscular dystrophy 2A | -1.438 | 4.9e-03 |
| medulloblastoma, large-cell | -1.900 | 8.1e-05 |
| osteosarcoma | 3.154 | 3.2e-09 |
| ovarian cancer | -1.900 | 1.1e-06 |
| pancreatic cancer | 1.100 | 8.0e-03 |
| pancreatic ductal adenocarcinoma liver m... | -1.867 | 7.6e-04 |
| Pick disease | 1.600 | 9.0e-03 |
| primitive neuroectodermal tumor | -1.100 | 4.4e-04 |
| Rheumatoid arthritis | 1.700 | 7.9e-03 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid EggNOG |
MPEDQAGAAMEEASPYSLLDICLNFLTTHLEKFCSARQDGTLCLQEPGVFPQEVADRLLRTMAFHGLLND 1 - 70 GTVGIFRGNQMRLKRACIRKAKISAVAFRKAFCHHKLVELDATGVNADITITDIISGLGSNKWIQQNLQC 71 - 140 LVLNSLTLSLEDPYERCFSRLSGLRALSITNVLFYNEDLAEVASLPRLESLDISNTSITDITALLACKDR 141 - 210 LKSLTMHHLKCLKMTTTQILDVVRELKHLNHLDISDDKQFTSDIALRLLEQKDILPNLVSLDVSGRKHVT 211 - 280 DKAVEAFIQQRPSMQFVGLLATDAGYSEFLTGEGHLKVSGEANETQIAEALKRYSERAFFVREALFHLFS 281 - 350 LTHVMEKTKPEILKLVVTGMRNHPMNLPVQLAASACVFNLTKQDLAAGMPVRLLADVTHLLLKAMEHFPN 351 - 420 HQQLQKNCLLSLCSDRILQDVPFNRFEAAKLVMQWLCNHEDQNMQRMAVAIISILAAKLSTEQTAQLGTE 421 - 490 LFIVRQLLQIVKQKTNQNSVDTTLKFTLSALWNLTDESPTTCRHFIENQGLELFMRVLESFPTESSIQQK 491 - 560 VLGLLNNIAEVQELHSELMWKDFIDHISSLLHSVEVEVSYFAAGIIAHLISRGEQAWTLSRSQRNSLLDD 561 - 630 LHSAILKWPTPECEMVAYRSFNPFFPLLGCFTTPGVQLWAVWAMQHVCSKNPSRYCSMLIEEGGLQHLYN 631 - 700 IKDHEHTDPHVQQIAVAILDSLEKHIVRHGRPPPCKKQPQARLN 701 - 744 //
