Property Summary

NCBI Gene PubMed Count 11
PubMed Score 8.84
PubTator Score 8.59

Knowledge Summary


No data available


  Disease (2)

Disease Target Count P-value
ovarian cancer 8491 2.6e-10
psoriasis 6685 1.6e-07
osteosarcoma 7933 2.7e-04
Gaucher disease type 1 171 2.5e-02
Disease Target Count Z-score Confidence
Acute monocytic leukemia 11 3.7 1.9


  Differential Expression (4)

Disease log2 FC p
psoriasis -1.200 1.6e-07
osteosarcoma -1.700 2.7e-04
ovarian cancer 1.700 2.6e-10
Gaucher disease type 1 1.200 2.5e-02

Gene RIF (5)

24771066 These results suggest that ZNF580 mediates eNOS expression and endothelial cell migration/proliferation via the TGF-b1/ALK5/Smad2 pathway, and thus plays a crucial role in vascular endothelial cells.
21830064 H2O2 upregulates the expression of ZNF580 via the NF-kappaB signaling pathway, and overexpression of ZNF580 plays a critical role in augmenting the release of pro-inflammatory cytokine IL-8.
21599657 ZNF580 is a binding partner of Smad2 and is involved in the signal transduction of the transforming growth factor-beta signalling pathway.
21310414 ZNF580 is a novel factor in the lipoprotein-dependent regulation of endothelial IL-8 expression and monocyte arrest.
20382120 These results elucidate the important role that ZNF580 plays in the process of migration and proliferation of endothelial cells, which provides a foundation for a novel approach to regulate angiogenesis.

AA Sequence

THRARAGPPHTCPLCPRRFQDAAELAQHVRLH                                          141 - 172

Text Mined References (14)

PMID Year Title
24771066 2014 ZNF580 mediates eNOS expression and endothelial cell migration/proliferation via the TGF-?1/ALK5/Smad2 pathway.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
21830064 2012 ROS-induced ZNF580 expression: a key role for H2O2/NF-?B signaling pathway in vascular endothelial inflammation.
21599657 2011 ZNF580, a novel C2H2 zinc-finger transcription factor, interacts with the TGF-? signal molecule Smad2.
21310414 2011 Suppression of zinc finger protein 580 by high oxLDL/LDL-ratios is followed by enhanced expression of endothelial IL-8.
20382120 2010 Sphingosine-1-phosphate induces human endothelial VEGF and MMP-2 production via transcription factor ZNF580: novel insights into angiogenesis.
18669648 2008 A quantitative atlas of mitotic phosphorylation.
17207965 2007 hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
16341674 2005 Transcriptome analysis of human gastric cancer.
16189514 2005 Towards a proteome-scale map of the human protein-protein interaction network.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
8889548 1996 Normalization and subtraction: two approaches to facilitate gene discovery.