Tbio ZNF521 Zinc finger protein 521

Protein Summary

Description

Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage; this interaction preventing EBF1 to bind DNA and activate target genes.

Uniprot Accession IDs

• Q96K83
• A3QVP7
• B0YJB7
• Q8IXI0
• Q8TES6
• Q9C065
• Q9HAL5
• Q9UFK4

Gene Name

• ZNF521

Ensembl ID

• ENST00000361524
• ENSP00000354794
• ENSG00000198795
• ENST00000538137
• ENSP00000440768

Symbol

• EHZF
• LIP3
• EHZF
• Evi3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.84
tissue sample	0.72
PubMedID	0.7
cell type or tissue	0.66
transcription factor binding site profile	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.28   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 176   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.28   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0