| Tdark | Zinc finger protein 397 |
Isoform 3 acts as a DNA-dependent transcriptional repressor.
This gene encodes a protein with a N-terminal SCAN domain, and the longer isoform contains nine C2H2-type zinc finger repeats in the C-terminal domain. The protein localizes to centromeres during interphase and early prophase, and different isoforms can repress or activate transcription in transfection studies. Multiple transcript variants encoding different isoforms have been found for this gene. Additional variants have been described, but their biological validity has not been determined. [provided by RefSeq, Oct 2009]
This gene encodes a protein with a N-terminal SCAN domain, and the longer isoform contains nine C2H2-type zinc finger repeats in the C-terminal domain. The protein localizes to centromeres during interphase and early prophase, and different isoforms can repress or activate transcription in transfection studies. Multiple transcript variants encoding different isoforms have been found for this gene. Additional variants have been described, but their biological validity has not been determined. [provided by RefSeq, Oct 2009]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8491 | 9.4e-11 |
| tuberculosis and treatment for 6 months | 686 | 1.1e-04 |
| Pick disease | 1893 | 1.2e-04 |
| group 3 medulloblastoma | 2254 | 2.4e-04 |
| Disease | log2 FC | p |
|---|---|---|
| group 3 medulloblastoma | 1.600 | 2.4e-04 |
| tuberculosis and treatment for 6 months | -1.200 | 1.1e-04 |
| Pick disease | 1.100 | 1.2e-04 |
| ovarian cancer | -2.200 | 9.4e-11 |
| PMID | Text | |
|---|---|---|
| 18369653 | ZNF397, a new class of interphase to early prophase-specific, SCAN-zinc-finger, mammalian centromere protein. |
MAVESGVISTLIPQDPPEQELILVKVEDNFSWDEKFKQNGSTQSCQELFRQQFRKFCYQETPGPREALSR 1 - 70 LQELCYQWLMPELHTKEQILELLVLEQFLSILPEELQIWVQQHNPESGEEAVTLLEDLEREFDDPGQQVP 71 - 140 ASPQGPAVPWKDLTCLRASQESTDIHLQPLKTQLKSWKPCLSPKSDCENSETATKEGISEEKSQGLPQEP 141 - 210 SFRGISEHESNLVWKQGSATGEKLRSPSQGGSFSQVIFTNKSLGKRDLYDEAERCLILTTDSIMCQKVPP 211 - 280 EERPYRCDVCGHSFKQHSSLTQHQRIHTGEKPYKCNQCGKAFSLRSYLIIHQRIHSGEKAYECSECGKAF 281 - 350 NQSSALIRHRKIHTGEKACKCNECGKAFSQSSYLIIHQRIHTGEKPYECNECGKTFSQSSKLIRHQRIHT 351 - 420 GERPYECNECGKAFRQSSELITHQRIHSGEKPYECSECGKAFSLSSNLIRHQRIHSGEEPYQCNECGKTF 421 - 490 KRSSALVQHQRIHSGDEAYICNECGKAFRHRSVLMRHQRVHTIK 491 - 534 //
| PMID | Year | Title | |
|---|---|---|---|
| 25755297 | 2015 | System-wide Analysis of SUMOylation Dynamics in Response to Replication Stress Reveals Novel Small Ubiquitin-like Modified Target Proteins and Acceptor Lysines Relevant for Genome Stability. | |
| 25416956 | 2014 | A proteome-scale map of the human interactome network. | |
| 23186163 | 2013 | Toward a comprehensive characterization of a human cancer cell phosphoproteome. | |
| 18369653 | 2008 | ZNF397, a new class of interphase to early prophase-specific, SCAN-zinc-finger, mammalian centromere protein. | |
| 18029348 | 2008 | Toward a confocal subcellular atlas of the human proteome. | |
| 16344560 | 2006 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. | |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | |
| 14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. | |
| 12801647 | 2003 | Identification and characterization of two novel human SCAN domain-containing zinc finger genes ZNF396 and ZNF397. | |
| 12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | |
| 1505991 | 1992 | Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. |
