| Tbio | Zinc finger protein 397 |
Isoform 3 acts as a DNA-dependent transcriptional repressor.
This gene encodes a protein with a N-terminal SCAN domain, and the longer isoform contains nine C2H2-type zinc finger repeats in the C-terminal domain. The protein localizes to centromeres during interphase and early prophase, and different isoforms can repress or activate transcription in transfection studies. Multiple transcript variants encoding different isoforms have been found for this gene. Additional variants have been described, but their biological validity has not been determined. [provided by RefSeq, Oct 2009]
This gene encodes a protein with a N-terminal SCAN domain, and the longer isoform contains nine C2H2-type zinc finger repeats in the C-terminal domain. The protein localizes to centromeres during interphase and early prophase, and different isoforms can repress or activate transcription in transfection studies. Multiple transcript variants encoding different isoforms have been found for this gene. Additional variants have been described, but their biological validity has not been determined. [provided by RefSeq, Oct 2009]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8520 | 9.4e-11 |
| tuberculosis and treatment for 6 months | 409 | 1.1e-04 |
| Pick disease | 1894 | 1.2e-04 |
| group 3 medulloblastoma | 4104 | 7.9e-03 |
| Disease | log2 FC | p |
|---|---|---|
| group 3 medulloblastoma | 1.500 | 7.9e-03 |
| ovarian cancer | -2.200 | 9.4e-11 |
| Pick disease | 1.100 | 1.2e-04 |
| tuberculosis and treatment for 6 months | -1.200 | 1.1e-04 |
MAVESGVISTLIPQDPPEQELILVKVEDNFSWDEKFKQNGSTQSCQELFRQQFRKFCYQETPGPREALSR 1 - 70 LQELCYQWLMPELHTKEQILELLVLEQFLSILPEELQIWVQQHNPESGEEAVTLLEDLEREFDDPGQQVP 71 - 140 ASPQGPAVPWKDLTCLRASQESTDIHLQPLKTQLKSWKPCLSPKSDCENSETATKEGISEEKSQGLPQEP 141 - 210 SFRGISEHESNLVWKQGSATGEKLRSPSQGGSFSQVIFTNKSLGKRDLYDEAERCLILTTDSIMCQKVPP 211 - 280 EERPYRCDVCGHSFKQHSSLTQHQRIHTGEKPYKCNQCGKAFSLRSYLIIHQRIHSGEKAYECSECGKAF 281 - 350 NQSSALIRHRKIHTGEKACKCNECGKAFSQSSYLIIHQRIHTGEKPYECNECGKTFSQSSKLIRHQRIHT 351 - 420 GERPYECNECGKAFRQSSELITHQRIHSGEKPYECSECGKAFSLSSNLIRHQRIHSGEEPYQCNECGKTF 421 - 490 KRSSALVQHQRIHSGDEAYICNECGKAFRHRSVLMRHQRVHTIK 491 - 534 //
