| Tbio | Zinc finger protein 33B |
May be involved in transcriptional regulation.
This gene encodes a member of the zinc finger family of proteins. This gene shows decreased expression in cumulus cells derived from patients undergoing controlled ovarian stimulation. This gene is present in a gene cluster with several related zinc finger genes in the pericentromeric region of chromosome 10. Pseudogenes have been identified on chromosomes 7 and 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
This gene encodes a member of the zinc finger family of proteins. This gene shows decreased expression in cumulus cells derived from patients undergoing controlled ovarian stimulation. This gene is present in a gene cluster with several related zinc finger genes in the pericentromeric region of chromosome 10. Pseudogenes have been identified on chromosomes 7 and 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| Breast cancer | 3098 | 1.6e-22 |
| osteosarcoma | 7933 | 2.9e-07 |
| atypical teratoid / rhabdoid tumor | 4369 | 7.8e-07 |
| group 4 medulloblastoma | 1875 | 1.4e-06 |
| malignant mesothelioma | 3163 | 3.3e-06 |
| medulloblastoma, large-cell | 6234 | 1.2e-04 |
| ovarian cancer | 8491 | 1.4e-04 |
| cystic fibrosis | 1670 | 2.0e-04 |
| interstitial cystitis | 2299 | 2.8e-04 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3289 | 4.8e-03 |
| lung cancer | 4473 | 1.6e-02 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2988 | 2.4e-02 |
| spina bifida | 1064 | 4.6e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Multiple endocrine neoplasia type 2B | 16 | 4.464 | 2.2 |
| Multiple endocrine neoplasia type 2A | 22 | 4.117 | 2.1 |
| Disease | log2 FC | p |
|---|---|---|
| malignant mesothelioma | -2.200 | 3.3e-06 |
| osteosarcoma | -1.586 | 2.9e-07 |
| group 4 medulloblastoma | 1.600 | 1.4e-06 |
| atypical teratoid / rhabdoid tumor | 1.600 | 7.8e-07 |
| medulloblastoma, large-cell | 2.200 | 1.2e-04 |
| intraductal papillary-mucinous carcinoma... | -1.200 | 2.4e-02 |
| intraductal papillary-mucinous neoplasm ... | -1.500 | 4.8e-03 |
| lung cancer | 1.100 | 1.6e-02 |
| interstitial cystitis | -1.100 | 2.8e-04 |
| cystic fibrosis | -1.300 | 2.0e-04 |
| spina bifida | -1.287 | 4.6e-02 |
| Breast cancer | -1.500 | 1.6e-22 |
| ovarian cancer | -1.300 | 1.4e-04 |
MNKVDQKFQGSVSFKDVTVGFTQEEWQHLDPSQRALYRDVMLENYSNLVSVGYCAHKPEVIFRLEQGEEP 1 - 70 WRLEEEFPSQSFPEVWTADHLKERSQENQSKHLWEVVFINNEMLTKEQGNVIGIPFNMDVSSFPSRKMFC 71 - 140 QYDSRGMSFNTVSELVISKINYLGKKSDEFNACGKLLLNIKHDETHTREKNEVLKNRNTLSHRENTLQHE 141 - 210 KIQTLDHNFEYSICQETLLEKAVFNTRKRENAEENNCDYNEFGRTFCDSSSLLFHQIPPSKDSHYEFSDC 211 - 280 EKFLCVKSTLSKHDGVPVKHYDCGESGNNFRRKLCLSQLQKGDKGEKHFECNECGKAFWEKSHLTRHQRV 281 - 350 HTGEKHFQCNQCGKTFWEKSNLTKHQRSHTGEKPFECNECGKAFSHKSALTLHQRTHTGEKPYQCNACGK 351 - 420 TFYQKSDLTKHQRTHTGQKPYECYECGKSFCMNSHLTVHQRTHTGEKPFECLECGKSFCQKSHLTQHQRT 421 - 490 HIGDKPYECNACGKTFYHKSVLTRHQIIHTGLKPYECYECGKTFCLKSDLTIHQRTHTGEKPFACPECGK 491 - 560 FFSHKSTLSQHYRTHTGEKPYECHECGKIFYNKSYLTKHNRTHTGEKPYECNECGKTFCQKSQLTQHQRI 561 - 630 HIGEKPYECNECGKAFCHKSALIVHQRTHTQEKPYKCNECGKSFCVKSGLILHERKHTGEKPYECNECGK 631 - 700 SFSHKSSLTVHHRAHTGEKSCQCNECGKIFYRKSDLAKHQRSHTGEKPYECNTCRKTFSQKSNLIVHQRT 701 - 770 HIGEKPYE 771 - 778 //
| PMID | Year | Title | |
|---|---|---|---|
| 25416956 | 2014 | A proteome-scale map of the human interactome network. | |
| 22451503 | 2012 | Hormonal and molecular characterization of follicular fluid, cumulus cells and oocytes from pre-ovulatory follicles in stimulated and unstimulated cycles. | |
| 16385451 | 2006 | A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. | |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | |
| 15164054 | 2004 | The DNA sequence and comparative analysis of human chromosome 10. | |
| 14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. | |
| 12566394 | 2003 | Genomic sequence and transcriptional profile of the boundary between pericentromeric satellites and genes on human chromosome arm 10p. | |
| 12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | |
| 8464732 | 1993 | Duplicated KOX zinc finger gene clusters flank the centromere of human chromosome 10: evidence for a pericentric inversion during primate evolution. | |
| 2288909 | 1990 | Multiple genes encoding zinc finger domains are expressed in human T cells. | |
| 2014798 | 1991 | Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering. | |
| 1639412 | 1992 | A cluster of expressed zinc finger protein genes in the pericentromeric region of human chromosome 10. |
