Property Summary

NCBI Gene PubMed Count 10
PubMed Score 4.45
PubTator Score 7.76

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (28)

Disease log2 FC p
gastric cancer 1.900 6.6e-04
hepatocellular carcinoma 1.600 5.4e-06
pancreatic cancer 1.200 6.5e-03
Waldenstrons macroglobulinemia 1.206 1.2e-02
Multiple myeloma 1.653 1.1e-04
astrocytic glioma 2.400 3.2e-03
ependymoma 2.600 1.2e-03
oligodendroglioma 2.600 1.4e-03
psoriasis 1.200 6.9e-08
osteosarcoma 2.660 2.7e-08
group 4 medulloblastoma 1.800 1.9e-03
glioblastoma 1.800 2.8e-03
medulloblastoma, large-cell 1.400 4.4e-03
primitive neuroectodermal tumor 1.100 7.1e-03
juvenile dermatomyositis 1.058 1.6e-07
acute quadriplegic myopathy 1.380 1.1e-06
pancreatic ductal adenocarcinoma liver m... 1.792 7.4e-04
intraductal papillary-mucinous adenoma (... 1.900 4.5e-04
intraductal papillary-mucinous carcinoma... 2.200 3.9e-04
intraductal papillary-mucinous neoplasm ... 2.000 5.9e-03
lung cancer 1.100 2.9e-03
sarcoidosis 1.100 1.7e-02
non primary Sjogren syndrome sicca -1.100 1.3e-02
pancreatic carcinoma 1.200 6.5e-03
Pick disease -2.500 6.5e-07
progressive supranuclear palsy -2.000 5.6e-03
ovarian cancer -2.500 9.8e-11
pituitary cancer -1.200 1.7e-03

Gene RIF (1)

PMID Text
26388440 BuGZ forms temperature-dependent liquid droplets alone or on microtubules in physiological buffers. Coacervation in vitro or in spindle and spindle matrix depends on hydrophobic residues in BuGZ. BuGZ coacervation and its binding to microtubules and tubulin are required to promote assembly of spindle and spindle matrix in Xenopus egg extract and in mammalian cells.

AA Sequence

MGRKKKKQLKPWCWYCNRDFDDEKILIQHQKAKHFKCHICHKKLYTGPGLAIHCMQVHKETIDAVPNAIP      1 - 70
GRTDIELEIYGMEGIPEKDMDERRRLLEQKTQESQKKKQQDDSDEYDDDDSAASTSFQPQPVQPQQGYIP     71 - 140
PMAQPGLPPVPGAPGMPPGIPPLMPGVPPLMPGMPPVMPGMPPGMMPMGGMMPPGPGIPPLMPGMPPGMP    141 - 210
PPVPRPGIPPMTQAQAVSAPGILNRPPAPTATVPAPQPPVTKPLFPSAGQMGTPVTSSSTASSNSESLSA    211 - 280
SSKALFPSTAQAQAAVQGPVGTDFKPLNSTPATTTEPPKPTFPAYTQSTASTTSTTNSTAAKPAASITSK    281 - 350
PATLTTTSATSKLIHPDEDISLEERRAQLPKYQRNLPRPGQAPIGNPPVGPIGGMMPPQPGIPQQQGMRP    351 - 420
PMPPHGQYGGHHQGMPGYLPGAMPPYGQGPPMVPPYQGGPPRPPMGMRPPVMSQGGRY                421 - 478
//

Text Mined References (13)

PMID Year Title
26388440 2015 Phase transition of spindle-associated protein regulate spindle apparatus assembly.
24462187 2014 BuGZ is required for Bub3 stability, Bub1 kinetochore function, and chromosome alignment.
24462186 2014 A microtubule-associated zinc finger protein, BuGZ, regulates mitotic chromosome alignment by ensuring Bub3 stability and kinetochore targeting.
22681889 2012 The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
21269460 2011 Initial characterization of the human central proteome.
18029348 2008 Toward a confocal subcellular atlas of the human proteome.
16625196 2006 DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
15635413 2005 Nucleolar proteome dynamics.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15146197 2004 Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
9799612 1998 ZNF207, a ubiquitously expressed zinc finger gene on chromosome 6p21.3.