Protein Summary
May be involved in transcriptional regulation. This gene product belongs to the zinc finger protein superfamily, members of which are regulatory proteins characterized by nucleic acid-binding zinc finger domains. The encoded protein contains 20 tandemly arrayed C2H2-type zinc fingers, a Kruppel-associated box (KRAB) domain, and a SCAN box. This transcript turns over rapidly and contains 3' UTR AUUUA motifs, which are often a hallmark of rapid turnover. It is overexpressed in some thyroid papillary carcinomas. This gene is located in a cluster of zinc finger genes at 3p21. Naturally-occurring readthrough transcription is observed between this gene and the upstream zinc finger protein 660 gene and is represented by GeneID:110354863. [provided by RefSeq, May 2017]
- ENST00000344387
- ENSP00000345809
- ENSG00000186448
- ENST00000383744
- ENSP00000373250
- ENST00000383745
- ENSP00000373251
- ENST00000396058
- ENSP00000379370
- ENST00000627517
- ENSP00000487305
- ENSG00000281709
- ENST00000627752
- ENSP00000486777
- ENST00000627845
- ENSP00000486739
- ENST00000628172
- ENSP00000485709
- ZKSCAN9
- ZNF166
- P18
- VHLaK
- ZNF20
- ZNF166
- ZKSCAN9
- ZSCAN41
- D3S1363E
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 0.85 | ||
microRNA | 0.72 | ||
virus perturbation | 0.72 | ||
histone modification site profile | 0.7 | ||
small molecule perturbation | 0.57 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.03 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 114 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.03 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 114 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0