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Tbio Zinc finger protein 135

Plays a role in the regulation of cell morphology and cytoskeletal organization. May be involved in transcriptional regulation.

 Comments

Property Summary

NCBI Gene PubMed Count 9
PubMed Score 107.36
PubTator Score 1064.75

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Disease Target Count P-value
psoriasis 6685 1.4e-72
medulloblastoma 1524 5.3e-10
atypical teratoid / rhabdoid tumor 4369 3.0e-04
Disease Target Count Z-score Confidence
Causalgia 2 3.415 1.7
Cancer 2346 3.162 1.6

Expression

  Differential Expression (3)

Disease log2 FC p
medulloblastoma 1.700 5.3e-10
atypical teratoid / rhabdoid tumor 1.100 3.0e-04
psoriasis -1.700 1.4e-72

Synonym

Accession P52742 B4DHH9 E9PEV2 F5GYY9 I3L0B3 Q5U5L3 Q8N1I7
Symbols pT3
ZNF61
pHZ-17
ZNF78L1

Gene

ZNF135

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (12)

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 GO Function (3)

 GO Component (1)

 GO Process (4)

 Compartment GO Term (12)

 HCA RNA Cell Line (41)

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Pathway (3)

AA Sequence 

MTPGVRVSTDPEQVTFEDVVVGFSQEEWGQLKPAQRTLYRDVMLDTFRLLVSVGHWLPKPNVISLLEQEA      1 - 70
ELWAVESRLPQGVYPDLETRPKVKLSVLKQGISEEISNSVILVERFLWDGLWYCRGEDTEGHWEWSCESL     71 - 140
ESLAVPVAFTPVKTPVLEQWQRNGFGENISLNPDLPHQPMTPERQSPHTWGTRGKREKPDLNVLQKTCVK    141 - 210
EKPYKCQECGKAFSHSSALIEHHRTHTGERPYECHECLKGFRNSSALTKHQRIHTGEKPYKCTQCGRTFN    211 - 280
QIAPLIQHQRTHTGEKPYECSECGKSFSFRSSFSQHERTHTGEKPYECSECGKAFRQSIHLTQHLRIHTG    281 - 350
EKPYQCGECGKAFSHSSSLTKHQRIHTGEKPYECHECGKAFTQITPLIQHQRTHTGEKPYECGECGKAFS    351 - 420
QSTLLTEHRRIHTGEKPYGCNECGKTFSHSSSLSQHERTHTGEKPYECSQCGKAFRQSTHLTQHQRIHTG    421 - 490
EKPYECNDCGKAFSHSSSLTKHQRIHTGEKPYECNQCGRAFSQLAPLIQHQRIHTGEKPYECNQCGRAFS    491 - 560
QSSLLIEHQRIHTKEKPYGCNECGKSFSHSSSLSQHERTHTGEKPYECHDCGKSFRQSTHLTQHRRIHTG    561 - 630
EKPYACRDCGKAFTHSSSLTKHQRTHTG                                              631 - 658
//

Text Mined References (11)

PMID Year Title
21834987 2011 Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15146197 2004 Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.
15057824 2004 The DNA sequence and biology of human chromosome 19.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
8478004 1993 Chromosomal localization of four human zinc finger cDNAs.
7557990 1995 Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders.
1946370 1991 Characterization and mapping of human genes encoding zinc finger proteins.
1505991 1992 Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes.