| Tdark | Zinc finger protein 124 |
May be involved in transcriptional regulation.
This gene encodes a protein with an amino-terminal KRAB-A box and multiple repeated Kruppel-type (C2H2) zinc finger motifs at its carboxy terminus. The encoded protein may function as a transcription factor. Expression of this gene is increased after vascular endothelial growth factor (VEGF) stimulation in human leukemia cell lines and results in inhibition of apoptotic cell death induced by irradiation or exposure to etoposide. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2014]
This gene encodes a protein with an amino-terminal KRAB-A box and multiple repeated Kruppel-type (C2H2) zinc finger motifs at its carboxy terminus. The encoded protein may function as a transcription factor. Expression of this gene is increased after vascular endothelial growth factor (VEGF) stimulation in human leukemia cell lines and results in inhibition of apoptotic cell death induced by irradiation or exposure to etoposide. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2014]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| medulloblastoma, large-cell | 6241 | 1.3e-06 |
| group 3 medulloblastoma | 4104 | 4.8e-05 |
| atypical teratoid / rhabdoid tumor | 5112 | 2.0e-04 |
| Pick disease | 1894 | 3.4e-04 |
| glioblastoma | 5792 | 1.5e-03 |
| primitive neuroectodermal tumor | 3035 | 1.6e-03 |
| lung cancer | 4740 | 3.0e-03 |
| psoriasis | 6694 | 5.5e-03 |
| osteosarcoma | 7950 | 1.1e-02 |
| non primary Sjogren syndrome sicca | 891 | 1.5e-02 |
| subependymal giant cell astrocytoma | 2287 | 4.3e-02 |
| active ulcerative colitis | 764 | 4.9e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| substance-related disorder | 162 | 0.0 | 1.1 |
| Disease | log2 FC | p |
|---|---|---|
| active ulcerative colitis | -1.242 | 4.9e-02 |
| atypical teratoid / rhabdoid tumor | 1.300 | 2.0e-04 |
| glioblastoma | 1.100 | 1.5e-03 |
| group 3 medulloblastoma | 1.800 | 4.8e-05 |
| lung cancer | 1.300 | 3.0e-03 |
| medulloblastoma, large-cell | 3.000 | 1.3e-06 |
| non primary Sjogren syndrome sicca | -1.600 | 1.5e-02 |
| osteosarcoma | -1.167 | 1.1e-02 |
| Pick disease | 1.800 | 3.4e-04 |
| primitive neuroectodermal tumor | 1.700 | 1.6e-03 |
| psoriasis | -1.100 | 5.5e-03 |
| subependymal giant cell astrocytoma | 1.542 | 4.3e-02 |
MSGHPGSWEMNSVAFEDVAVNFTQEEWALLDPSQKNLYRDVMQETFRNLASIGNKGEDQSIEDQYKNSSR 1 - 70 NLRHIISHSGNNPYGCEECGKKPCTCKQCQKTSLSVTRVHRDTVMHTGNGHYGCTICEKVFNIPSSFQIH 71 - 140 QRNHTGEKPYECMECGKALGFSRSLNRHKRIHTGEKRYECKQCGKAFSRSSHLRDHERTHTGEKPYECKH 141 - 210 CGKAFRYSNCLHYHERTHTGEKPYVCMECGKAFSCLSSLQGHIKAHAGEEPYPCKQCGKAFRYASSLQKH 211 - 280 EKTHIAQKPYVCNNCGKGFRCSSSLRDHERTHTGEKPYECQKCGKAFSRASTLWKHKKTHTGEKPYKCKK 281 - 350 M//
