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Tbio
ZGPAT
Zinc finger CCCH-type with G patch domain-containing protein

Protein Summary
Description
Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis. Isoform 4: Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328969
  • ENSP00000332013
  • ENSG00000197114
  • ENST00000355969
  • ENSP00000348242
  • ENST00000357119
  • ENSP00000349634
  • ENST00000369967
  • ENSP00000358984
  • ENST00000448100
  • ENSP00000391176

Symbol
  • GPATC6
  • GPATCH6
  • KIAA1847
  • ZC3H9
  • ZC3HDC9
  • ZIP
  • ZIP
  • ZC3H9
  • GPATC6
  • GPATCH6
  • ZC3HDC9
  • KIAA1847
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.86
biological process
0.79
transcription factor binding site profile
0.77
phenotype
0.74
tissue sample
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.44   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.44   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0