Tbio ZFYVE21 Zinc finger FYVE domain-containing protein 21

Protein Summary

Description

Plays a role in cell adhesion, and thereby in cell motility which requires repeated formation and disassembly of focal adhesions. Regulates microtubule-induced PTK2/FAK1 dephosphorylation, an event important for focal adhesion disassembly, as well as integrin beta-1/ITGB1 cell surface expression.

Uniprot Accession IDs

• Q9BQ24
• A8K3A4
• Q86T05
• Q96LT1
• ZF21

Gene Name

• ZFYVE21

Ensembl ID

• ENST00000216602
• ENSP00000216602
• ENSG00000100711
• ENST00000311141
• ENSP00000310543

Symbol

• ZF21
• HCVP7TP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.88
cell type or tissue	0.78
kinase perturbation	0.76
histone modification site profile	0.69
protein domain	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.17   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 90   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.17   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0