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Tbio
ZFAT
Zinc finger protein ZFAT

Protein Summary
Description
May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated (By similarity). This gene encodes a protein that likely binds DNA and functions as a transcriptional regulator involved in apoptosis and cell survival. This gene resides in a susceptibility locus for autoimmune thyroid disease (AITD) on chromosome 8q24. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377838
  • ENSP00000367069
  • ENSG00000066827
  • ENST00000520214
  • ENSP00000428483
  • ENST00000520727
  • ENSP00000427831
  • ENST00000523399
  • ENSP00000429091

Symbol
  • KIAA1485
  • ZFAT1
  • ZNF406
  • AITD3
  • ZFAT1
  • ZNF406
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.93
histone modification site profile
0.87
trait
0.86
cell type or tissue
0.84
transcription factor
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.24   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 38   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.24   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 38   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0