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Tbio
ZEB2
Zinc finger E-box-binding homeobox 2

Protein Summary
Description
Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters. Represses transcription of E-cadherin. The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000409487
  • ENSP00000386854
  • ENSG00000169554
  • ENST00000539609
  • ENSP00000443792
  • ENST00000558170
  • ENSP00000454157
  • ENST00000627532
  • ENSP00000487174

Symbol
  • KIAA0569
  • SIP1
  • ZFHX1B
  • ZFX1B
  • SIP1
  • SIP-1
  • ZFHX1B
  • HSPC082
  • SMADIP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.97
PubMedID
0.87
biological term
0.85
protein domain
0.85
transcription factor
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 650.56   (req: < 5)
Gene RIFs: 270   (req: <= 3)
Antibodies: 584   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 650.56   (req: >= 5)
Gene RIFs: 270   (req: > 3)
Antibodies: 584   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0