Tbio ZC3H3 Zinc finger CCCH domain-containing protein 3

Protein Summary

Description

Required for the export of polyadenylated mRNAs from the nucleus (PubMed:19364924). Enhances ACVR1B-induced SMAD-dependent transcription. Binds to single-stranded DNA but not to double-stranded DNA in vitro. Involved in RNA cleavage (By similarity).

Uniprot Accession IDs

• Q8IXZ2
• Q14163
• Q8N4E2
• Q9BUS4

Gene Name

• ZC3H3

Ensembl ID

• ENST00000262577
• ENSP00000262577
• ENSG00000014164

Symbol

• KIAA0150
• SMICL
• ZC3HDC3
• ZC3HDC3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.93
ligand (protein) perturbation	0.83
transcription factor binding site profile	0.77
cell line	0.75
histone modification site profile	0.7

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.79   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 96   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.79   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0