| Tdark | Zinc finger BED domain-containing protein 5 |
This gene is unusual in that its coding sequence is mostly derived from Charlie-like DNA transposon; however, it does not appear to be an active DNA transposon as it is not flanked by terminal inverted repeats. The encoded protein is conserved among the mammalian Laurasiatheria branch. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2009]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8520 | 7.8e-10 |
| medulloblastoma, large-cell | 6241 | 2.9e-05 |
| Multiple myeloma | 1332 | 5.1e-05 |
| dermatomyositis | 966 | 1.6e-04 |
| osteosarcoma | 7950 | 2.0e-03 |
| group 3 medulloblastoma | 4104 | 2.1e-03 |
| Waldenstrons macroglobulinemia | 765 | 6.7e-03 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 2.9e-02 |
| Disease | log2 FC | p |
|---|---|---|
| dermatomyositis | 1.700 | 1.6e-04 |
| group 3 medulloblastoma | 1.100 | 2.1e-03 |
| medulloblastoma, large-cell | 1.200 | 2.9e-05 |
| Multiple myeloma | 1.701 | 5.1e-05 |
| osteosarcoma | -1.146 | 2.0e-03 |
| ovarian cancer | -2.200 | 7.8e-10 |
| pancreatic ductal adenocarcinoma liver m... | 1.130 | 2.9e-02 |
| Waldenstrons macroglobulinemia | 1.083 | 6.7e-03 |
MIAPLLCILSYNFNTFAILNVYSKLTMFCTTNSLPMDLLLKQGSLKQEVESFCYQIVSESNDQKVGILQS 1 - 70 EDKQLQPSVSKKSEGELSRVKFISNSNKITFSKKPKRRKYDESYLSFGFTYFGNRDAPHAQCVLCKKILS 71 - 140 NSSLAPSKLRRHLETKHAAYKDKDISFFKQHLDSPENNKPPTPKIVNTDNESATEASYNVSYHIALSGEA 141 - 210 HTIGELLIKPCAKDVVMRMFDEQYSKKIDAVQLSNSTVARRIKDLAADIEEELVCRLKICDGFSLQLDES 211 - 280 ADVSGLAVLLVFVRYRFNKSIEEDLLLCESLQSNATGEEIFNCINSFMQKHEIEWEKCVDVCSDASRAVD 281 - 350 GKIAEAVTLIKYVAPESTSSHCLLYRHALAVKIMPTSLKNVLDQAVQIINYIKARPHQSRLLKILCEEMG 351 - 420 AQHTALLLNTEVRWLSRGKVLVRLFELRRELLVFMDSAFRLSDCLTNSSWLLRLAYLADIFTKLNEVNLS 421 - 490 MQGKNVTVFTVFDKMSSLLRKLEFWASSVEEENFDCFPTLSDFLTEINSTVDKDICSAIVQHLRGLRATL 491 - 560 LKYFPVTNDNNAWVRNPFTVTVKPASLVARDYESLIDLTSDSQVKQNFSELSLNDFWSSLIQEYPSIARR 561 - 630 AVRVLLPFATMHLCETGFSYYAATKTKYRKRLDAAPHMRIRLSNITPNIKRICDKKTQKHCSH 631 - 693 //
