| Tdark | Zinc finger BED domain-containing protein 5 |
This gene is unusual in that its coding sequence is mostly derived from Charlie-like DNA transposon; however, it does not appear to be an active DNA transposon as it is not flanked by terminal inverted repeats. The encoded protein is conserved among the mammalian Laurasiatheria branch. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2009]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8491 | 7.8e-10 |
| osteosarcoma | 7933 | 3.6e-06 |
| medulloblastoma, large-cell | 6234 | 2.9e-05 |
| Multiple myeloma | 1327 | 5.1e-05 |
| dermatomyositis | 966 | 1.6e-04 |
| group 3 medulloblastoma | 2254 | 2.1e-03 |
| Waldenstrons macroglobulinemia | 764 | 6.7e-03 |
| pancreatic ductal adenocarcinoma liver metastasis | 1795 | 2.9e-02 |
| Disease | log2 FC | p |
|---|---|---|
| Waldenstrons macroglobulinemia | 1.083 | 6.7e-03 |
| Multiple myeloma | 1.701 | 5.1e-05 |
| osteosarcoma | 1.549 | 3.6e-06 |
| medulloblastoma, large-cell | 1.200 | 2.9e-05 |
| pancreatic ductal adenocarcinoma liver m... | 1.130 | 2.9e-02 |
| group 3 medulloblastoma | 1.100 | 2.1e-03 |
| ovarian cancer | -2.200 | 7.8e-10 |
| dermatomyositis | 1.700 | 1.6e-04 |
| PMID | Text | |
|---|---|---|
| 20877624 | Observational study of gene-disease association. (HuGE Navigator) | |
| 20379614 | Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | |
| 18976975 | Knockdown of zinc finger, BED-type containing 5 (ZBED5) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells |
MIAPLLCILSYNFNTFAILNVYSKLTMFCTTNSLPMDLLLKQGSLKQEVESFCYQIVSESNDQKVGILQS 1 - 70 EDKQLQPSVSKKSEGELSRVKFISNSNKITFSKKPKRRKYDESYLSFGFTYFGNRDAPHAQCVLCKKILS 71 - 140 NSSLAPSKLRRHLETKHAAYKDKDISFFKQHLDSPENNKPPTPKIVNTDNESATEASYNVSYHIALSGEA 141 - 210 HTIGELLIKPCAKDVVMRMFDEQYSKKIDAVQLSNSTVARRIKDLAADIEEELVCRLKICDGFSLQLDES 211 - 280 ADVSGLAVLLVFVRYRFNKSIEEDLLLCESLQSNATGEEIFNCINSFMQKHEIEWEKCVDVCSDASRAVD 281 - 350 GKIAEAVTLIKYVAPESTSSHCLLYRHALAVKIMPTSLKNVLDQAVQIINYIKARPHQSRLLKILCEEMG 351 - 420 AQHTALLLNTEVRWLSRGKVLVRLFELRRELLVFMDSAFRLSDCLTNSSWLLRLAYLADIFTKLNEVNLS 421 - 490 MQGKNVTVFTVFDKMSSLLRKLEFWASSVEEENFDCFPTLSDFLTEINSTVDKDICSAIVQHLRGLRATL 491 - 560 LKYFPVTNDNNAWVRNPFTVTVKPASLVARDYESLIDLTSDSQVKQNFSELSLNDFWSSLIQEYPSIARR 561 - 630 AVRVLLPFATMHLCETGFSYYAATKTKYRKRLDAAPHMRIRLSNITPNIKRICDKKTQKHCSH 631 - 693 //
| PMID | Year | Title | |
|---|---|---|---|
| 23533661 | 2013 | ZBED evolution: repeated utilization of DNA transposons as regulators of diverse host functions. | |
| 23166581 | 2012 | Comparative analysis of the recently discovered hAT transposon TcBuster in human cells. | |
| 20877624 | 2010 | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. | |
| 20379614 | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | ||
| 17974005 | 2007 | The full-ORF clone resource of the German cDNA Consortium. | |
| 16554811 | 2006 | Human chromosome 11 DNA sequence and analysis including novel gene identification. | |
| 16344560 | 2006 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. | |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | |
| 15231748 | 2004 | Functional proteomics mapping of a human signaling pathway. | |
| 14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. | |
| 12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | |
| 10607616 | 1999 | Interspersed repeats and other mementos of transposable elements in mammalian genomes. |
