Tchem | Tyrosine-protein kinase ZAP-70 |
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Comments
Property Summary
Ligand Count | 20 |
NCBI Gene PubMed Count | 276 |
PubMed Score | 798.23 |
PubTator Score | 1050.46 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Severe combined immunodeficiency | 51 | 4.359 | 2.2 |
AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 2 | 1 | 0.0 | 0.0 |
Immunodeficiency 48 | 1 | 0.0 | 0.0 |
Immunologic Deficiency Syndromes | 113 | 0.0 | 0.0 |
T cell immunodeficiency primary | 1 | 0.0 | 0.0 |
Disease | Target Count | P-value |
---|---|---|
ovarian cancer | 8520 | 9.6e-04 |
osteosarcoma | 7950 | 2.2e-03 |
interstitial cystitis | 2312 | 2.9e-03 |
cutaneous lupus erythematosus | 1057 | 3.5e-02 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Chronic Lymphocytic Leukemia | 262 | 7.338 | 3.7 |
T cell deficiency | 8 | 4.109 | 2.1 |
Lymphoma | 81 | 3.617 | 1.8 |
Chromosome 13q14 deletion syndrome | 6 | 3.483 | 1.7 |
Lymphoproliferative syndrome | 58 | 3.108 | 1.6 |
Disease | Target Count |
---|---|
CD8 Deficiency, Familial | 2 |
Disease | log2 FC | p |
---|---|---|
cutaneous lupus erythematosus | 1.100 | 3.5e-02 |
interstitial cystitis | 1.700 | 2.9e-03 |
osteosarcoma | -1.330 | 2.2e-03 |
ovarian cancer | -1.100 | 9.6e-04 |
Species | Source | Disease |
---|---|---|
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA | ||
Inparanoid OMA | ||
Inparanoid EggNOG | ||
Inparanoid OMA | ||
Inparanoid OMA | ||
Inparanoid OMA | ||
Inparanoid OMA | ||
Inparanoid OMA |
CHEMBL112518
pIC50 7.59
CHEMBL3642587
pIC50 7.62
CHEMBL475251
pKd 7.68
CHEMBL3262622
pIC50 7.75
CHEMBL603469
pKd 7.80
CHEMBL3262616
pIC50 7.85
CHEMBL325912
pIC50 7.96
CHEMBL573483
pIC50 8.00
CHEMBL575048
pIC50 8.00
CHEMBL3642579
pIC50 8.05
CHEMBL388978
pIC50 8.06
CHEMBL112346
pIC50 8.10
CHEMBL3642588
pIC50 8.10
CHEMBL3642590
pIC50 8.10
CHEMBL3415583
pIC50 8.28
CHEMBL3642585
pIC50 8.70
CHEMBL3642578
pIC50 9.00
aloisine
pKi 5.58
Syk inhibitor II
pIC50 4.95
TAK-659
pIC50 7.13
MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTYA 1 - 70 IAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRDAMVRDYVRQTWKLEGEALEQ 71 - 140 AIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTYALSLIYGKTVYH 141 - 210 YLISQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAPTLPAHPSTLTHP 211 - 280 QRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFG 281 - 350 SVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGG 351 - 420 PLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADD 421 - 490 SYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMEC 491 - 560 PPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPGSTQKAEAACA 561 - 619 //