Property Summary

NCBI Gene PubMed Count 22
PubMed Score 25.17
PubTator Score 18.10

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (1)

Disease Target Count Z-score Confidence
Cleft Lip 91 4.921 2.5
Cleft palate 125 4.123 2.1

Expression

 GO Function (1)

Gene RIF (12)

PMID Text
26075712 This association study successfully identified two susceptibility Single Nucleotide Polymorphisms, (WNT9B and PBX1) associated with Mayer-Rokitansky-Kuster-Hauser syndrome risk, both separately and interactively.
24852367 Genome association study shows a highly conserved 32 kb intergenic region containing regulatory elements between WNT3 and WNT9B in patients with classic bladder exstrophy.
24581601 results indicate that mutations in the coding sequence of WNT9B are not responsible for Mullerian duct abnormalities in the Chinese population
24268733 Two novel mutations (a missense mutation in exon 1, and one in the 3-UTR) may be pathogenic variants in Mayer-Rokitansky-Kuster-Hauser syndrome patients and warrant further functional study.
23974041 The signals from the stromal fibroblasts cooperate with Wnt9b to promote differentiation of the progenitor cells.
23785285 secretion of WNT2B and WNT9B and stabilization of beta-catenin (CTNNB1) upon virus infection negatively regulate expression of representative inducible genes IFNB1, IFIT1 and TNF in a CTNNB1-dependent effector mechanism
20890934 Observational study of gene-disease association. (HuGE Navigator)
20672350 Observational study of gene-disease association. (HuGE Navigator)
20634891 Observational study of gene-disease association. (HuGE Navigator)
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19171330 Mutations in the coding sequence of WNT4, WNT5A, WNT7A, and WNT9B are not responsible for the Mayer-Rokitansky-Kuster-Hauser syndrome.
18413325 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)

AA Sequence

MRPPPALALAGLCLLALPAAAASYFGLTGREVLTPFPGLGTAAAPAQGGAHLKQCDLLKLSRRQKQLCRR      1 - 70
EPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGRMGLLKRGFKETAFLYAVSSAALTHTLARACSAGRM     71 - 140
ERCTCDDSPGLESRQAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTC    141 - 210
KCHGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNEALGRLELWAPARQGSLTKGLAPRSGD    211 - 280
LVYMEDSPSFCRPSKYSPGTAGRVCSREASCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEE    281 - 350
LVYTCKH                                                                   351 - 357
//

Text Mined References (24)

PMID Year Title
26075712 2015 Associations of Polymorphisms in WNT9B and PBX1 with Mayer-Rokitansky-Küster-Hauser Syndrome in Chinese Han.
25640183 2015 Functional consequences of 17q21.31/WNT3-WNT9B amplification in hPSCs with respect to neural differentiation.
24852367 2014 Genome-wide association study and mouse expression data identify a highly conserved 32 kb intergenic region between WNT3 and WNT9b as possible susceptibility locus for isolated classic exstrophy of the bladder.
24581601 2014 WNT9B in 542 Chinese women with Müllerian duct abnormalities: mutation analysis.
24268733 2014 Analysis of WNT9B mutations in Chinese women with Mayer-Rokitansky-Küster-Hauser syndrome.
23974041 2013 Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation.
23785285 2013 Genome-wide RNAi screen reveals a new role of a WNT/CTNNB1 signaling pathway as negative regulator of virus-induced innate immune responses.
22808956 2012 Genetically distinct subsets within ANCA-associated vasculitis.
20890934 2010 Studies with Wnt genes and nonsyndromic cleft lip and palate.
20672350 2010 Genetic variants in COL2A1, COL11A2, and IRF6 contribute risk to nonsyndromic cleft palate.
20634891 2010 Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
20093360 2010 Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6.
19171330 2009 Mutational analysis of the WNT gene family in women with Mayer-Rokitansky-Kuster-Hauser syndrome.
18413325 2008 Variation in WNT genes is associated with non-syndromic cleft lip with or without cleft palate.
16625196 2006 DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
16258938 2006 Expression patterns of Wnt genes during development of an anterior part of the chicken eye.
12975309 2003 The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
12573259 2003 Mouse Wnt9b transforming activity, tissue-specific expression, and evolution.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11713592 2001 Expression of WNT14 and WNT14B mRNAs in human cancer, up-regulation of WNT14 by IFNgamma and up-regulation of WNT14B by beta-estradiol.
11604992 2001 Molecular cloning and characterization of WNT14B, a novel member of the WNT gene family.
9441749 1997 Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21.
8167409 1993 Wnt family proteins are secreted and associated with the cell surface.