You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
WLS
Protein wntless homolog

Protein Summary
Description
Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262348
  • ENSP00000262348
  • ENSG00000116729
  • ENST00000354777
  • ENSP00000346829
  • ENST00000370976
  • ENSP00000360015

Symbol
  • C1orf139
  • GPR177
  • EVI
  • MRP
  • GPR177
  • mig-14
  • C1orf139
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
trait
0.86
ligand (protein) perturbation
0.83
PubMedID
0.83
interacting protein
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 179   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 179   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0