Property Summary

NCBI Gene PubMed Count 14
PubMed Score 36.98
PubTator Score 21.89

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (19)

Disease log2 FC p
Multiple myeloma 1.733 7.4e-04
malignant mesothelioma -1.100 3.7e-06
astrocytic glioma -1.600 4.8e-02
psoriasis -1.100 3.9e-03
glioblastoma 1.300 1.8e-02
osteosarcoma -1.265 2.0e-02
group 4 medulloblastoma -2.700 7.0e-07
medulloblastoma, large-cell -2.100 1.3e-03
intraductal papillary-mucinous carcinoma... 1.100 1.6e-02
colon cancer -1.300 2.1e-02
active Crohn's disease 1.082 4.5e-03
interstitial cystitis 1.600 3.7e-05
non primary Sjogren syndrome sicca 1.100 2.4e-02
subependymal giant cell astrocytoma 1.114 3.9e-02
pulmonary arterial hypertension -1.300 4.5e-02
mucosa-associated lymphoid tissue lympho... 1.937 7.2e-03
ovarian cancer 2.200 2.7e-04
pituitary cancer -2.200 2.8e-08
dermatomyositis 1.400 3.5e-03

Gene RIF (9)

PMID Text
25462558 The specific autophagosomal localization of both WIPI1 and WIPI2 (refered to as WIPI puncta) has been employed to assess autophagy using fluorescence microscopy methods, such as confocal and live-cell video microscopy
25233424 Data suggest WIPI1/WIPI2 co-localize with microtubule-associated light chain 3 and autophagy related proteins 2/14L, participate in biogenesis of phagosomes, autophagy, and mobilization of lipids to/from intracellular droplets. [review-like article]
24991767 WIPI-1 and WIPI-2 are functionally required in mediating the PI3P signal at the onset of autophagy in NB4 cells.
24384561 the detection of WIPI1 mRNA is likely to be a convenient method of monitoring autophagosome formation in a wide range of cell types
21564513 Freeze-fracture replica immunolabelling reveals WD-repeat protein interacting with phosphoinositides 1 and 2 (WIPI-1 and WIPI-2) as membrane components of autophagosomes and the plasma membrane (PM).
21317285 Studies define a distinct role for WIPI1 and TORC1 signaling in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is distinct from starvation-induced autophagy.
19936222 Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
17618624 Quantification of WIPI-1 puncta should be suitable to assay mammalian autophagy
15602573 share an evolutionary conserved function in autophagy and that autophagic capacity may be compromised in human cancers

AA Sequence

MEAEAADAPPGGVESALSCFSFNQDCTSLATGTKAGYKLFSLSSVEQLDQVHGSNEIPDVYIVERLFSSS      1 - 70
LVVVVSHTKPRQMNVYHFKKGTEICNYSYSSNILSIRLNRQRLLVCLEESIYIHNIKDMKLLKTLLDIPA     71 - 140
NPTGLCALSINHSNSYLAYPGSLTSGEIVLYDGNSLKTVCTIAAHEGTLAAITFNASGSKLASASEKGTV    141 - 210
IRVFSVPDGQKLYEFRRGMKRYVTISSLVFSMDSQFLCASSNTETVHIFKLEQVTNSRPEEPSTWSGYMG    211 - 280
KMFMAATNYLPTQVSDMMHQDRAFATARLNFSGQRNICTLSTIQKLPRLLVASSSGHLYMYNLDPQDGGE    281 - 350
CVLIKTHSLLGSGTTEENKENDLRPSLPQSYAATVARPSASSASTVPGYSEDGGALRGEVIPEHEFATGP    351 - 420
VCLDDENEFPPIILCRGNQKGKTKQS                                                421 - 446
//

Text Mined References (24)

PMID Year Title
25462558 2015 Fluorescence-based imaging of autophagy progression by human WIPI protein detection.
25233424 2014 WIPI ?-propellers at the crossroads of autophagosome and lipid droplet dynamics.
24991767 2014 WIPI-dependent autophagy during neutrophil differentiation of NB4 acute promyelocytic leukemia cells.
24384561 2014 Detection of WIPI1 mRNA as an indicator of autophagosome formation.
23088497 2012 Defining regulatory and phosphoinositide-binding sites in the human WIPI-1 ?-propeller responsible for autophagosomal membrane localization downstream of mTORC1 inhibition.
22829830 2012 WIPI-1 Positive Autophagosome-Like Vesicles Entrap Pathogenic Staphylococcus aureus for Lysosomal Degradation.
21896713 2011 Ca2+/calmodulin-dependent kinase (CaMK) signaling via CaMKI and AMP-activated protein kinase contributes to the regulation of WIPI-1 at the onset of autophagy.
21564513 2011 Freeze-fracture replica immunolabelling reveals human WIPI-1 and WIPI-2 as membrane proteins of autophagosomes.
21317285 2011 WIPI1 coordinates melanogenic gene transcription and melanosome formation via TORC1 inhibition.
20639694 2010 Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins.
20529838 2010 The Bcl-2 homology domain 3 mimetic gossypol induces both Beclin 1-dependent and Beclin 1-independent cytoprotective autophagy in cancer cells.
20505359 2010 Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation.
20484055 2010 Starvation-induced hyperacetylation of tubulin is required for the stimulation of autophagy by nutrient deprivation.
20114074 2010 AMPK-independent induction of autophagy by cytosolic Ca2+ increase.
20059746 2010 Modulation of local PtdIns3P levels by the PI phosphatase MTMR3 regulates constitutive autophagy.
19936222 2009 Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis.
19590496 2009 Control of autophagy initiation by phosphoinositide 3-phosphatase Jumpy.
17618624 2007 Human WIPI-1 puncta-formation: a novel assay to assess mammalian autophagy.
16625196 2006 DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
15602573 2004 WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15020712 2004 PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.