Tdark WFDC8 WAP four-disulfide core domain protein 8

Protein Summary

Description

This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. The encoded protein contains a Kunitz-inhibitor domain, in addition to three WFDC domains. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. Two alternatively spliced transcript variants have been found for this gene, and they encode the same protein. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8IUA0
• E1P623
• Q5TDV2
• Q96A34

Gene Name

• WFDC8

Ensembl ID

• ENST00000289953
• ENSP00000289953
• ENSG00000158901
• ENST00000357199
• ENSP00000361735

Symbol

• C20orf170
• WAP8
• WAP8
• C20orf170
• HEL-S-292
• dJ461P17.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.93
microRNA	0.54
protein domain	0.41
tissue	0.4
tissue sample	0.4

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.01   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 30   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.01   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 30   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0