Tdark WFDC6 WAP four-disulfide core domain protein 6

Protein Summary

Description

This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. Read-through transcription exists between this gene and the upstream SPINLW1 (serine peptidase inhibitor-like, with Kunitz and WAP domains 1) gene. [provided by RefSeq, Nov 2010]

Uniprot Accession IDs

• Q9BQY6
• Q3MJ23
• Q5JYQ4
• Q8NFV6

Gene Name

• WFDC6

Ensembl ID

• ENST00000372665
• ENSP00000361750
• ENSG00000243543
• ENST00000372670
• ENSP00000361755

Symbol

• C20orf171
• WAP6
• WAP6
• C20orf171
• HEL-S-295
• dJ461P17.11

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.73
tissue sample	0.39
cell line	0.34
tissue	0.33
protein domain	0.26

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.64   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 2   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.64   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 2   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0