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Tbio
WDR81
WD repeat-containing protein 81

Protein Summary
Description
Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. In this process, may regulate the interaction of SQSTM1 with ubiquitinated proteins and also recruit MAP1LC3C (PubMed:28404643). May also be involved in maintenance of normal mitochondrial structure and organization (By similarity). This gene encodes a multi-domain transmembrane protein which is predominantly expressed in the brain and is thought to play ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309182
  • ENSP00000312074
  • ENSG00000167716
  • ENST00000409644
  • ENSP00000386609
  • ENST00000419248
  • ENSP00000407845
  • ENST00000437219
  • ENSP00000391074
  • ENST00000611758
  • ENSP00000480442
  • ENSG00000276021
  • ENST00000613381
  • ENSP00000480101
  • ENST00000613616
  • ENSP00000477991

Symbol
  • HYC3
  • CAMRQ2
  • SORF-2
  • PPP1R166
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.89
disease perturbation
0.74
protein domain
0.73
transcription factor binding site profile
0.73
cell line
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.01   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 13   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.01   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 13   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0