Tdark WDR24 GATOR complex protein WDR24

Protein Summary

Description

As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway (PubMed:23723238, PubMed:27166823). Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:26449471, PubMed:26586190, PubMed:27487210). In addition to its role in regulation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux (PubMed:27166823).

Uniprot Accession IDs

• Q96S15
• A2IDB8
• D3DU59
• Q96GC7
• Q9H0B7

Gene Name

• WDR24

Ensembl ID

• ENST00000248142
• ENSP00000248142
• ENSG00000127580
• ENST00000293883
• ENSP00000293883

Symbol

• C16orf21
• JFP7
• C16orf21

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell line	0.71
tissue sample	0.71
transcription factor	0.68
transcription factor binding site profile	0.63
histone modification site profile	0.62

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.94   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 36   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.94   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 36   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0