WDR20
WD repeat-containing protein 20
Protein Summary
Regulator of deubiquitinating complexes. Activates deubiquitinating activity of complexes containing USP12 (PubMed:20147737, PubMed:27373336). Anchors at the base of the ubiquitin-contacting loop of USP12 and remotely modulates the catalytic center of the enzyme (PubMed:27373336). This gene encodes a WD repeat-containing protein that functions to preserve and regulate the activity of the USP12-UAF1 deubiquitinating enzyme complex. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2011]
- ENST00000299135
- ENSP00000299135
- ENSG00000140153
- ENST00000322340
- ENSP00000314209
- ENST00000335263
- ENSP00000335434
- ENST00000342702
- ENSP00000341037
- ENST00000454394
- ENSP00000406084
- ENST00000555879
- ENSP00000452470
- ENST00000556511
- ENSP00000451633
- ENST00000556807
- ENSP00000450636
- DMR
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.88 | ||
histone modification site profile | 0.84 | ||
microRNA | 0.81 | ||
transcription factor perturbation | 0.8 | ||
transcription factor binding site profile | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 113.58 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 98 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 113.58 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 98 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0