Tbio VWA2 von Willebrand factor A domain-containing protein 2

Protein Summary

Description

This gene encodes a member of the von Willebrand factor A-like domain protein superfamily. The encoded protein is localized to the extracellular matrix and may serve as a structural component in basement membranes or in anchoring structures on scaffolds of collagen VII or fibrillin. This gene has been linked to type 1A diabetes and is a candidate serological marker for colon cancer. [provided by RefSeq, Jan 2013]

Uniprot Accession IDs

• Q5GFL6
• A1A5D4
• B5MDJ8
• Q6ZS39
• Q6ZWJ7
• Q708C5
• Q70UZ8

Gene Name

• VWA2

Ensembl ID

• ENST00000392982
• ENSP00000376708
• ENSG00000165816
• ENST00000603594
• ENSP00000473752

Symbol

• AMACO
• AMACO
• CCSP2
• NET42
• CCSP-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.74
PubMedID	0.57
tissue sample	0.52
cell line	0.49
cell type or tissue	0.48

Protein Classes

PANTHER Classes

Protein / Receptor / Von Willebrand Factor A Domain-containing Protein 2

DTO Classes

Protein / Receptor / Von Willebrand Factor A Domain-containing Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.96   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 95   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.96   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0