Tdark VSTM5 V-set and transmembrane domain-containing protein 5

Protein Summary

Description

Cell adhesion-like membrane protein of the central nervous system (CNS) which modulates both the position and complexity of central neurons by altering their membrane morphology and dynamics. Involved in the formation of neuronal dendrites and protrusions including dendritic filopodia. In synaptogenesis, regulates synapse formation by altering dendritic spine morphology and actin distribution. Promotes formation of unstable neuronal spines such as thin and branched types. Regulates neuronal morphogenesis and migration during cortical development in the brain.

Uniprot Accession IDs

• A8MXK1

Gene Name

• VSTM5

Ensembl ID

• ENST00000409977
• ENSP00000386607
• ENSG00000214376

Symbol

• C11orf90
• C11orf90

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.8
tissue	0.78
cell type or tissue	0.65
histone modification site profile	0.63
PubMedID	0.52

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / V-set And Transmembrane Domain-containing Protein 5

Protein / Signaling Molecule / V-set And Transmembrane Domain-containing Protein 5

Protein / Receptor / Cytokine Receptor / Immunoglobulin Receptor Superfamily / V-set And Transmembrane Domain-containing Protein 5

Protein / Defense/immunity Protein / Immunoglobulin Receptor Superfamily / V-set And Transmembrane Domain-containing Protein 5

Protein / Cell Adhesion Molecule / V-set And Transmembrane Domain-containing Protein 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.74   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 28   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.74   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 28   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0