VRK3
Inactive serine/threonine-protein kinase VRK3
Protein Summary
Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates and inactivates ERK in the nucleus. This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. In both human and mouse, this gene has substitutions at several residues within the ATP binding motifs that in other kinases have been shown to be required for catalysis. In vitro assays indicate the protein lacks phosphorylation activity. The protein, however, likely retains its substrate binding capability. This gene is widely expressed in human tissues and its protein localizes to the nucleus. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]
- ENST00000316763
- ENSP00000324636
- ENSG00000105053
- ENST00000377011
- ENSP00000366210
- ENST00000594092
- ENSP00000472541
- ENST00000594948
- ENSP00000473171
- ENST00000599538
- ENSP00000469880
- ENST00000601341
- ENSP00000470156
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 1 | ||
molecular function | 0.95 | ||
histone modification site profile | 0.89 | ||
transcription factor perturbation | 0.88 | ||
disease perturbation | 0.87 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10.12 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 80 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10.12 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 80 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0